岸本忠三

キシモトタダミツ | Kishimoto Tadamitsu

所属機関・部署：
職名：特任教授

研究分野 (2件)：内科学一般 , 免疫学

研究キーワード (5件)： Clinical Immunology and Allergy , Immnology , アレルギー内科学 , 免疫 , 免疫学

競争的資金等の研究課題 (31件)：

2015 - 2018 MAPKシグナルに関連したArid5aタンパク質分解機構の解明
2014 - 2016 感染時および自己免疫疾患におけるArid5aの生理学的機能の詳細な解明
2013 - 2016 免疫細胞および自己免疫疾患のIL-6 mRNA調節におけるArid5aの役割
1997 - 2003 感染症と免疫病の分子生物学と医学
1999 - 2002 高次複雑系免疫システムの情報伝達制御

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論文 (232件)：

Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto, et al. Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2402226121
Sujin Kang, Shinya Onishi, Zhenzhen Ling, Hitomi Inoue, Yingying Zhang, Hao Chang, Hui Zhao, Tong Wang, Daisuke Okuzaki, Hiroshi Matsuura, et al. Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 2. e2315898120
Masashi Narazaki, Tadamitsu Kishimoto. Current status and prospects of IL-6-targeting therapy. Expert Review of Clinical Pharmacology. 2022. 15. 5. 575-592
Siddhika Pareek, Xenia Sanchenkova, Taiki Sakaguchi, Mari Murakami, Ryu Okumura, Hisako Kayama, Saya Kawauchi, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, et al. Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine. Genes to cells : devoted to molecular & cellular mechanisms. 2022. 27. 4. 243-253
Kishan Kumar Nyati, Shigeru Hashimoto, Shailendra Kumar Singh, Murat Tekguc, Hozaifa Metwally, Yu-Chen Liu, Daisuke Okuzaki, Yohannes Gemechu, Sujin Kang, Tadamitsu Kishimoto. The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway. Cancer Letters. 2021. 520. 295-306

MISC (197件)：

Sujin Kang, Toshio Tanaka, Hitomi Inoue, Chikako Ono, Shoji Hashimoto, Yoshiyuki Kioi, Hisatake Matsumoto, Hiroshi Matsuura, Tsunehiro Matsubara, Kentaro Shimizu, et al. COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 21
Hozaifa Metwally, Toshio Tanaka, Songling Li, Gyanu Parajuli, Sujin Kang, Hamza Hanieh, Shigeru Hashimoto, Jaya P Chalise, Yohannes Gemechu, Daron M Standley, et al. Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production. Science signaling. 2020. 13. 624
Hozaifa Metwally, Toshio Tanaka, Tadamitsu Kishimoto. Arid5a expression is induced through MYD88-independent pathway in response to TLR4 stimulation in IFNy-sensitized human macrophages.'. JOURNAL OF IMMUNOLOGY. 2017. 198. 1
Masashi Narazaki, Toshio Tanaka, Tadamitsu Kishimoto. The role and therapeutic targeting of IL-6 in rheumatoid arthritis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2017. 13. 6. 535-551
Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto. Immunotherapeutic implications of IL-6 blockade for cytokine storm. IMMUNOTHERAPY. 2016. 8. 8. 959-970

書籍 (2件)：

B lymphocyte activation, proliferation and immunoglobulin secretion.
Fundamental Immunology, Raven Press, New York 1989
B lymphocyte activation, proliferation and immunoglobulin secretion.
Fundamental Immunology, Raven Press, New York 1989

学位 (1件)：

医学博士 (大阪大学)

委員歴 (24件)：

2002 - 日本医学会副会長
2002 - The Japanese Association of Medical Sciences vice-president
1997 - 1998 日本アレルギー学会会長
1997 - 1998 Japanese Society of Allergology president
1986 - 1997 Immunology Board, US-Japan Medical Cooperative Program chairman

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受賞 (26件)：

2003 - ロベルト・コッホゴールドメダル
2003 - Robert Koch Gold Medal
1998 - 文化勲章
1998 - The Order of Culture from Emperor
1996 - アベリー・ランドスタイナー賞(The Avery-Landsteiner Prize from the German Immunology Society)

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所属学会 (26件)：

日本医学会 , 米国血液学会 , 米国国立科学アカデミー医学研究所 , 日本臨床免疫学会 , 日本アレルギー学会 , 日本学士院 , 国際サイトカイン学会 , 米国免疫学会 , 米国国立科学アカデミー , 国際免疫薬理学会 , 日本免疫学会 , 国際免疫学会連合 , The Japanese Association of Medical Sciences , American Society of Hematology , USA , The Institute of Medicine of the National Academy of Science , Japanese Society of Clinical Immunology , Japanese Society of Allergology , The Japan Academy , International Cytokine Society , The American Association of Immunologists , The US National Academy of Science , International Society of Immunopharmacology , Japanese Society of Immunology , US-Japan Medical Cooperative Program , Immunology Board

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岸本忠三