Hanafusa Hiroshi

ハナフサヒロシ | Hanafusa Hiroshi

Affiliation and department：
Job title： Associate professor
Other affiliations (2)：

Research field (1)： Cell biology

Research theme for competitive and other funds (23)：

2019 - 2021 メンブレントラフィックによるEGFRシグナルの時空間制御
2018 - 2021 Regulation of membrane traffic by ROCO family kinase LRRK1/2
2017 - 2019 エンドソームを起点とするシグナル発信機構の解明
2015 - 2018 Analysis of the licensing mechanism of centriole duplication by using Separase Sensor
2015 - 2018 Regulation of retrograde transport mediated by LRRK1-Dynein complex

2015 - 2017 LRRK1による中心体複製及びシリアdisassembly制御機構の解析

2012 - 2016 Mechanism of signal transduction regulating axon regeneration

2013 - 2015 LRRK1による中心体複製サイクル/シリア伸長制御機構の解析

2012 - 2014 Analysis of the regulation of asymmetric cell division by using the artificially induced polarization of HeLa cells.

2011 - 2014 Analysis of the spatiotemporal regulation of EGFR signal by LRRK1

2011 - 2013 LRRK1によるEGFRリソソーム分解経路選別機構の解析

2009 - 2011 Spatio-temporal regulation of cellular trafficking and signal transduction

2009 - 2010 ROCOファミリー分子LRRK1によるEGFR細胞内トラフィック制御機構の解析

2007 - 2008 Analysis of the molecular mechanism how cells monitor the duration of ERK activity

2006 - 2007 転写因子XGrhl3によるWntシグナル阻害メカニズムの解析と外胚葉分化

2005 - 2006 ERK活性化時間をモニターする細胞内分子メカニズムの解明

2005 - 2005 周辺制御因子によるRas/MAPキナーゼ経路の時空間的活性化機構の解析

2005 - 2005 上皮形成を司る転写因子XGRHによるWntシグナル阻害メカニズムの解明

2004 - 2005 Xenopus初期胚におけるERK経路の活性化時間に応じた細胞運命決定機構の解析

2004 - 2004 アフリカツメガエルをモデル系とした体軸形成に重要な遺伝子群の網羅的解析

2003 - 2004 Xenopusをモデル動物としたSproutyによるネガティブフィードバック機構

2003 - 2003 アフリカツメガエルをモデル系とした体軸形成に重要な遺伝子群の網羅的解析

2003 - 2003 Ras/MAPキナーゼ経路の阻害因子Sproutyの活性制御機構の解析

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Papers (35)：

Hiroshi Hanafusa, Keitaro Fujita, Misa Kamio, Shiori Iida, Yasushi Tamura, Naoki Hisamoto, Kunihiro Matsumoto. LRRK1 functions as a scaffold for PTP1B-mediated EGFR sorting into ILVs at the ER-endosome contact site. Journal of Cell Science. 2023. 136. 6
Yoshiki Sakai, Hiroshi Hanafusa, Naoki Hisamoto, Kunihiro Matsumoto. Histidine dephosphorylation of the Gβ protein GPB-1 promotes axon regeneration in C. elegans. EMBO reports. 2022. 23. 12. e55076
Keitaro Fujita, Shin Kedashiro, Takuya Yagi, Naoki Hisamoto, Kunihiro Matsumoto, Hiroshi Hanafusa. The ULK complex-LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation. Journal of cell science. 2022. 135. 23
Hiroshi Hanafusa, Shin Kedashiro, Mako Gotoh, Ko-Hei Saitoh, Hironori Inaba, Tomoki Nishioka, Kozo Kaibuchi, Masaki Inagaki, Naoki Hisamoto, Kunihiro Matsumoto. LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport. Journal of cell science. 2022. 135. 21
Naoki Hisamoto, Yoshiki Sakai, Kohei Ohta, Tatsuhiro Shimizu, Chun Li, Hiroshi Hanafusa, Kunihiro Matsumoto. CDK14 promotes axon regeneration by regulating the non-canonical Wnt signaling pathway in a kinase-independent manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021. 41. 40. 8309-8320

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Work history (5)：

2015/09 - 現在 Nagoya University Graduate School of Science Division of Biological Science Cell Regulation Associate professor
2013/12 - 2015/08 Nagoya University Graduate School of Science Division of Biological Science Cell Regulation Lecturer
2007/04 - 2013/11 Nagoya University Graduate School of Science Division of Biological Science Assistant Professor
2007/03/31 - Nagoya University Graduate School of Science Division of Biological Science Assistant
2002/03 - 2007/03 Nagoya University Assistant

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