Rchr
J-GLOBAL ID:200901001388786641
Update date: Jan. 31, 2024
Nishibori Masahiro
西堀 正洋 | Nishibori Masahiro
Affiliation and department:
Job title:
Specifically-appointed Professor
Homepage URL (2):
https://www.okayama-u.ac.jp/user/translre/
,
https://www.okayama-u.ac.jp/user/translre/en/
Research field (2):
Medical biochemistry
, Pharmacology
Research keywords (4):
医化学一般
, 薬理学一般
, Biochemistry
, Pharmacology
Research theme for competitive and other funds (41):
- 2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
- 2021 - 2024 Verification of preventative effects of monoclonal HMGB1 antibody for spinal cord injury after aortic operation
- 2021 - 2024 HMGB1-HRGバランスに着目した川崎病新規治療薬の開発
- 2020 - 2023 組織障害性HMGB1に着眼した肺虚血再灌流障害に対する新規戦略の確立
- 2020 - 2023 新規S100A8/A9阻害分子の発見に基づいたがん脳指向転移の機構解明とその制御
- 2019 - 2022 Malnutrition delayed wound healing by HMGB1-related prolonged inflammation
- 2019 - 2022 Roles of histidine-rich glycoprotein in prevention of hypertensive disorders of pregnancy and in physiological placental development.
- 2019 - 2022 Analysis dynamics of HMGB1 as a biosensor molecule and its multiple functions
- 2018 - 2021 Basic study of the niche function improvement medicine development that targeted a homeodynamics-related mediator
- 2016 - 2019 Therapeutic Potential of an Anti-High Mobility Group Box1 Monoclonal Antibody in Hemorrhagic stroke
- 2016 - 2019 Functional characterization of histidine-rich glycoprotein (HRG) under the inflammatory conditions.
- 2016 - 2018 Functional analysis of HMGB1 as an inflammatory mediator in periodontitis
- 2015 - 2018 Research for homeodynamics regeneration-promoting drug discovery
- 2015 - 2018 Mechanism for microthrombus formation on NETosis and development of therapy for ARDS.
- 2015 - 2017 Therapeutic effects of anti-high mobility group box-1 monoclonal antibody for influenza A virus (H1N1)- induced pneumonia
- 2014 - 2017 Novel therapeutic strategy targeting advanced glycation end product
- 2013 - 2016 A novel pathological mechanism of Alzheimer's disease as a chronic inflammation through RAGE signal activity.
- 2013 - 2015 Drug development for sepsis by regulation of neutrophils
- 2012 - 2015 Development of monoclonal antibodies therapy for cerebral infarction and cerebral edema in primate animal mode
- 2012 - 2015 Basic scientific research for formulating drugs for treatment of hypertension
- 2012 - 2015 Drug development for brain and spinal cord trauma targeting HMGB1
- 2011 - 2013 The development of broad-spectrum antitumor agents with anti-HMGB1 antibody and clarification of its action mechanism
- 2011 - 2012 Development oftherapy for acute traumatic brain injury
- 2009 - 2011 Development of monoclonal antibodies therapy for cerebral infarction and cerebral edema
- 2009 - 2011 Mechanism for HMGB-or HMGB1-derived peptide-induced increase in BBB permeability
- 2009 - 2010 脳浮腫の発生機序解明と創薬標的の同定
- 2008 - 2010 A novel anti-HMGB1 Ab therapy for treatment of B-cell lymphoma
- 2007 - 2008 虚血性脳障害と学習・記憶過程に共通する原理の探索研究
- 2007 - 2008 Development of antibody therapy for brain infarction
- 2006 - 2007 The Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart.
- 2005 - 2006 サイトカイン活性を有する核転写因子、ヌクレオサイトカインの情報伝達と敗血症病態
- 2004 - 2005 Study on regulation of tissue remodeling by histidine rich plasma factors
- 2003 - 2004 The analysis of the molecular physiology of the protease-activated receptors in digestive system disease
- 2003 - 2004 Inducible histamine protects mice from P.acnes-primed and LPS-induced hepatitis through H2-receptor stimulation
- 2003 - 2004 Proteomics analysis of plasma protein complex regulating leukocyte interaction.
- 1997 - 1998 A role of a novel brain-derived proteinase inhibitor in the apoptosis in neurons
- 1994 - 1994 脳由来の新しいセルピン様蛋白質の構造と機能に関する研究
- 1993 - 1993 CD63関連遺伝子クローニングとその蛋白機能解析
- 1993 - 1993 脳内微量透析法によるオピオイド系とヒスタミン系の相互作用に関する研究
- 1989 - 1989 脳のモノアミン類の神経性取り込みに及ぼす抗ヒスタミン薬の影響に関する研究
- 1988 - 1988 実験的糖尿病マウスにおける中枢ヒスタミン作動ニューロン機能に関する研究
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Papers (295):
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Simeng Ma, Yoki Nakamura, Takahiro Kochi, Suzuna Uemoto, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Morioka. Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 221-226
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Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori. Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products. Biotechnology and applied biochemistry. 2023
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Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi. Different modulation of STING/TBK1/IRF3 signaling by advanced glycation end products. Archives of biochemistry and biophysics. 2023. 750. 109808-109808
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Hitoshi Murata, May Tha Zin Phoo, Toshiki Ochi, Nahoko Tomonobu, Ken-Ichi Yamamoto, Rie Kinoshita, Ikuko Miyazaki, Masahiro Nishibori, Masato Asanuma, Masakiyo Sakaguchi. Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration. Journal of biochemistry. 2023
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Shiho Kitaoka, Ayaka Tomohiro, Shinya Ukeshima, Keyue Liu, Hidenori Wake, Shinya H. Kimura, Yasuhiko Yamamoto, Masahiro Nishibori, Tomoyuki Furuyashiki. Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice. Cells. 2023. 12. 13. 1789-1789
more...
MISC (193):
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Daiki Ousaka, Masahiro Nishibori. Is hemolysis a novel therapeutic target in COVID-19?. FRONTIERS IN IMMUNOLOGY. 2022. 13
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圓尾賢悟, 池田裕哉, 坪田真帆, 王登莉, 西堀正洋, 南達郎, 伊藤彰敏, 川畑篤史. 活性化プロテインCは神経障害性疼痛を抑制する:Proteinase-activated receptor-1(PAR1)の関与について. 生体機能と創薬シンポジウム要旨集. 2022. 2022
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圓尾賢悟, 坪田真帆, 田島和樹, 関口富美子, 西堀正洋, 南達郎, 伊藤彰敏, 川畑篤史. Thrombomodulin alfaのoxaliplatin誘発性末梢神経障害抑制作用発現におけるHMGB1不活性化とprotein C及びTAFI活性化の相対的重要性と下流シグナル分子の解析. 日本薬理学雑誌. 2022. 157. Supplement
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堂本莉紗, 田村ひなの, 関口富美子, 坪田真帆, 西堀正洋, 川畑篤史. 抗リウマチ薬sulfasalazineはマクロファージからのHMGB1遊離を抑制することでlipopolysaccharide誘起アロディニアを抑制する. 日本薬理学雑誌. 2022. 157. Supplement
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岸本彩野, 堂本莉紗, 松永浩明, 松本亜紗菜, 坪田真帆, 関口富美子, 王登莉, 西堀正洋, 川畑篤史. Oxaliplatin誘起末梢神経障害には血小板由来HMGB1が関与する. 日本薬理学雑誌. 2022. 157. Supplement
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Patents (18):
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好中球活性化に起因する疾患の治療薬及び検査方法(JP:医療技術)
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外傷性神経障害治療剤(JP)
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ヒト化抗HMGB1抗体もしくはその抗原結合性断片(JP)
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HUMANIZED ANTI-HMGBl ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF
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THERAPEUTIC AGENT, METHOD OF TREATMENT AND METHOD FOR PREDICTING THE SEVERITY OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS), DISEASES CAUSED OR ACCOMPANIED BY NEUTROPHIL ACTIVATION
more...
Lectures and oral presentations (250):
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虚血性脳障害の鍵分子HMGB1と標的抗体治療
(第53回広島神経医科学研究会 2018)
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Histidine-rich glycoprotein (HRG)の好中球制御による敗血症治療薬の可能性
(第132回日本薬理学会近畿部会 2017)
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Involvement of HMGB1 in postoperative pain.
(Neuroscience 2017 2017)
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Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice.
(8th International DAMPs and Alarmins Symposium 2017)
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Anti-HMGB1 monoclonal antibody therapy for broad range of CNS injuries: development of humanized antibody.
(8th International DAMPs and Alarmins Symposium 2017)
more...
Works (1):
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平成21年度 全国発明表彰 21世紀発明奨励賞
2009 -
Education (2):
- - 1980 Okayama University Medical School Faculty of Medicine
- - 1980 Okayama University Faculty of Medicine
Professional career (1):
- Doctor of philosophy (Okayama University)
Work history (10):
- 2021/04 - 現在 Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences Department of Translational Research & Drug Development Specifically-appointed Professor
- 2001/04 - 2021/03 - 岡山大学医歯薬学総合研究科 教授
- 1995 - 2001 Okayama University Medical School
- 2001 - - Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
- 1988 - 1995 Okayama University Medical School
- 1988 - 1995 Senior Assistant Professor,Medical School,Okayama University
- 1991 - 1992 カナダ・マニトバ大学医学部マニトバ細胞生物研究所 Visiting professor
- 1990 - 1991 カナダ・マニトバ大学医学部マニトバ細胞生物研究所 Research Associate
- 1980 - 1988 Research Associate,Medical School,Okayama University
- 1980 - 1988 Research Associate,Medical School,Okayama University
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Committee career (1):
Awards (9):
- 2021/03 - 公益社団法人日本薬理学会 第14回江橋節郎賞
- 2015 - セコム科学技術振興財団研究奨励賞
- 2014 - ライフサイエンス振興財団創立30周年記念特別研究奨励賞
- 2012 - 山陽新聞賞奨励賞(学術功労)
- 2012 - バイオビジネスアワードJapan2012彩都賞
- 2010 - 岡山県文化賞 学術部門
- 2009 - 平成21年度 全国発明表彰 21世紀発明奨励賞
- 2002 - 第40回三島海雲記念学術奨励賞
- 1990 - 上原生命科学財団 海外留学助成リサーチフェローシップ
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Association Membership(s) (5):
国際薬理学会議
, 日本ヒスタミン学会
, 米国神経科学会(Society for Neuroscience)
, 日本神経科学会
, 日本薬理学会
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