Rchr
J-GLOBAL ID：200901001389635213
Update date: Apr. 12, 2024
HIGUCHI KEIICHI
ヒグチ ケイイチ | HIGUCHI KEIICHI
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-byotai/
Research field (3)：
Pathobiochemistry
, Sports science
, Experimental pathology
Research keywords (4)：
Sports Medical Science
, Aging
, Model mice
, Amyloidosis
Research theme for competitive and other funds (66)：
- 2023 - 2026 マウスとヒトを用いたインターバル運動の健康増進機序の解明と効果評価法の開発
- 2018 - 2021 XEpigenetic mechanisms for age-associated decline in physiological function
- 2017 - 2021 Validation of life extension effect of reduced form Coenzyme Q10
- 2017 - 2020 Integrative pathology of Amyloidosis: Exploratory research on the basis of transmission phenomena
- 2016 - 2020 Molecular pathogenesis of amyloidosis: Integration of protein chemistry, mouse models and clinical pathology
- 2015 - 2018 The preventive effects of exercise + milk product intake on lifestyle-related diseases and heat illness: the establishment of remote research system on a large population of subjects
- 2014 - 2018 Analysis of Amyloid Related Proteins with Advanced Laser Microdissection
- 2014 - 2017 Development of preventive and therapeutic treatments based on the pathogenesis of the transmission of amyloidosis
- 2014 - 2017 Molecular design of novel phenylpropanoid-derived anti-amyloidal compounds using quantum-dot probes
- 2013 - 2016 Development and application of a reporter bioassay system to screen for phytochemicals mimicking the anti-aging effects of caloric restriction
- 2013 - 2016 Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal models
- 2013 - 2016 Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.
- 2012 - 2016 Preventive effects and molecular mechanisms for metabolic abnormalities by a short-term intervention of caloric restriction and exercise
- 2012 - 2015 The mechanisms for deterioration of thermoregulatory responses in older people and the counter measure against their heat illness
- 2011 - 2014 Pathological Investigation of the Pathogenesis and Development of Preventive and Therapeutic Procedures for Amyloidosis
- 2011 - 2013 Molecular modeling of anti-amyloidal catechol derivatives using amyloidogenic proteins
- 2011 - 2013 Comprehensive Proteome Analysis of Age-related Changes in Amyloid Like Aggregates
- 2010 - 2012 Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse model
- 2010 - 2011 アミロイド線維の伝播によるタンパク質社会の秩序破綻と回復機構の解析
- 2009 - 2011 Health promotional effects of the combination of supplementation and exercise in old mice having various genetic backgrounds
- 2008 - 2010 Systemic analysis of amyloidosis using animal models
- 2006 - 2008 Use of genetically altered mice to develop new preventives against familial amyloidoses.
- 2006 - 2008 Molecular pathogenesis of dialysis-related amyloidosis-A fusion of the in vitro model and the animal model-
- 2005 - 2008 Molecular-genetic analysis of age related hearing impairment
- 2005 - 2007 a-adrenergic receptor responsiveness and baroreflex control of muscle blood flow:human and animal studies
- 2005 - 2007 Investigation into the pathogenesis of amyloidosis using the newly developed animal models.
- 2005 - 2006 アミロイドーシス伝播機構解明と感染物質検出システムの開発
- 2005 - 2006 病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析
- 2005 - 2006 熟年体育大学を基盤とした運動効率関連遺伝子の探策
- 2003 - 2005 Elucidation of the molecular pathogenesis of dialysis-related amyloidosis.
- 2004 - 2004 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定
- 2003 - 2004 病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析
- 2003 - 2004 RESEARCH ON THE MOLECULAR MECHANISM UNDERLYING THE TRANSMISSION PHENOMENON IN AMYLOIDOSES INVOLVING HUMAN NEUROLOGICAL SYSTEMS
- 2002 - 2004 Molecular Genetic Analysis of Senescence-Accelerated Mouse (SAM)
- 2003 - 2003 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定
- 2003 - 2003 アミロイド線維による伝播/感染機構と宿主応答の解析
- 2002 - 2003 Analysis and application of newly discovered rat L1 retotransposon
- 2002 - 2003 新たに発見された活性型L1レトロトランスポゾンの実験病理学への応用
- 2001 - 2003 A new exercise training program for the elderly by developing a novel handy calorie meter and an IT network system after the determination of human genome sequences.
- 2002 - 2002 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定
- 2002 - 2002 アミロイドタンパク質の病的構造伝播機構の解析
- 1999 - 2001 Effects of restricted food intake and spontaneous wheel running on aging and longevity in senescence-accelerated mouse ( SAM )
- 1997 - 2001 Roles of molecular chaperones in cell function
- 2000 - 2000 自然突然変異型OGG1を持つマウス群を用いたDNA酸化傷害と発がんとの関連の解明
- 1999 - 2000 Analysis of the mechanism of misfolding to amyloid protein using mouse amyloidosis
- 1999 - 2000 Analysis of repair systems for oxidative DNA damage in Senescence-Accelerated Mouso
- 1999 - 2000 マウス個体老化の分子的把握:老化臓器の遺伝子発現レパートリィの作成
- 1998 - 1998 アミロイド蛋白(apoA-II)の線維構造への変換を制御する分子シャペロン
- 1997 - 1998 Studies of the Pathogenesis of Amyloidosis : Verification of the Hypothesis 'Transmission of Abnormal Proteins Structure' Using Mouse Senile Amyloidosis.
- 1997 - 1998 Molecular and Cellular Basis of Senescence Acceleration
- 1997 - 1997 マウスアミロイド蛋白(apoA-II)の構造交換と分子シャペロン
- 1996 - 1997 Effect protein deficiency on lnsulin like growth factor-I and lnsulin like growth factor-II gene expression physiological reles of lnsulin like growth factors as a local factore in growing lambs-
- 1996 - 1997 Relationship between age-related immune dysfunction and senile amyloidosis in shortened life length in SAM mice
- 1995 - 1996 Development of the Gene Therapeutic Treatment to Mouse Senile Amyloidosis
- 1991 - 1993 Comprehensive studies on age-related deficits in learning and memory in SAM
- 1991 - 1992 Molecular genetic analysis of muirne senile amyloidosis.
- 1990 - 1992 Development of murine models for aging brain, Senescence-Accelerated Mouse (SAM)
- 1990 - 1990 ApoB mRNAに出現するゲノDNAにコ-ドサれないストップコドンに関する研究
- 1989 - 1990 Modulatory Effect of Dietary Restriction on the Advance of Senescence in Senescence Accelerated Mouse (SAM)
- 1989 - 1990 Molecular Genetic Study of Mouse Senile Amyloidosis
- 1989 - 1989 ApoBmRNAに出現するゲノムDNAにコ-ドされないストップコドンに関する研究
- 1987 - 1988 A New Strain of Mice with Late-appearing Cataract, It's development from Senescence Accelerated Mouse (SAM) and characters of cataract.
- 1986 - 1988 Experimental studies on the pathogenesis and modulation of age-related pathologies in Senescence Acelerated Mouse (SAM).
- リポタンパク質特にHDLの代謝調整の基礎的研究
- アミロイド-シス発祥機構の分子生物学的研究
- マウス特に老化促進モデルマウス(SAM)を用いた老化、寿命、老化病態の遺伝的要因の解析
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Papers (143)：
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Giada Andreotti, Julian Baur, Marijana Ugrina, Peter Benedikt Pfeiffer, Max Hartmann, Sebastian Wiese, Hiroki Miyahara, Keiichi Higuchi, Nadine Schwierz, Matthias Schmidt, et al. Insights into the structural basis of amyloid resistance provided by cryo-EM structures of AApoAII amyloid fibrils. Journal of molecular biology. 2024. 168441-168441
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Xiaojing Kang, Shin Shimada, Hiroki Miyahara, Keiichi Higuchi, Masayuki Mori. BALB.NCT-Cpox nct is a unique mouse model of hereditary coproporphyria. Molecular genetics and metabolism reports. 2023. 35. 100964-100964
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Hiroki Miyahara, Jian Dai, Ying Li, Xiaoran Cui, Hibiki Takeuchi, Naomi Hachiya, Fuyuki Kametani, Masahide Yazaki, Masayuki Mori, Keiichi Higuchi. Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2023. 30. 2. 225-238
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Ying Li, Jian Dai, Fuyuki Kametani, Masahide Yazaki, Akihito Ishigami, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi. Renal Function in Aged C57BL/6J Mice Is Impaired by Deposition of Age-Related Apolipoprotein A-II Amyloid Independent of Kidney Aging. The American journal of pathology. 2023. 193. 6. 725-739
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Masayuki Mori, Jian Dai, Hiroki Miyahara, Ying Li, Xiaojing Kang, Kazuto Yoshimi, Tomoji Mashimo, Keiichi Higuchi, Kiyoshi Matsumoto. Cyba and Nox2 mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner. Experimental animals. 2023. 72. 2. 233-241
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MISC (65)：
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宮原 大貴, 矢崎 正英, 樋口 京一. 最先端医療の今 プロテオミクスに基づく加齢性アミロイドーシスの抑制機構. Medical Science Digest. 2023. 49. 13. 708-709
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樋口 京一. 【proteinopathy最前線】アミロイドーシス. BIO Clinica. 2023. 38. 3. 224-228
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亢 暁静, 森 政之, 代 健, 宮原 大貴, 劉 暢, 五十嵐 佑一, 崔 小冉, 李 瑩, 樋口 京一. コプロポルフィリノーゲン酸化酵素遺伝子変異マウスは心筋変性を呈する. 血管. 2021. 44. 1. 62-62
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樋口 京一. 山なみのはるかに. 信州医学雑誌. 2021. 69. 1. 11-13
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樋口 京一, 森 政之. 【2025年問題を見据えたエージング研究と医薬品開発】老化モデル動物を用いたエージング研究. ファルマシア. 2020. 56. 11. 1004-1008
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Lectures and oral presentations (4)：
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Deposition if Age-related ApolipoproteinA-II and Medin Amyloidosis in Aged C57BL/6J Mice
(2024)
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老化に伴うタンパク質恒常性の破綻:アミロイドーシス
(第96回日本生化学大会 シンポジウム 老化を制御するプロテオスタシスとその変容 2023)
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C57BL/6Jマウスにおける加齢に伴うMedin沈着病態の検討
(第10回日本アミロイドーシス学会学術集会 2023)
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Molecular Mechanisms of;Exercise Training Effects.
(2023)
Education (2)：
- 1980 - 1984 Kyoto University Graduate School of Medicine
- 1978 - 1980 Kyoto University Graduate School of Agriculture
Professional career (1)：
Work history (7)：
- 2023/04 - 現在 Meio University Faculty of Human Health Sciences Professor
- 2021/04 - 現在 Shinshu University
- 2021/03 - 2023/04 Nagano University of Health and Medicine Community Health Care Research Center Professor
- 2019/04 - 2021/03 信州大学群バイオメディカル 研究所 ニューロヘルスイノベーション部門 教授
- 1998/03 - 2019/03 Shinshu University Graduate School of Medicine Medical Sciences Professor
- 1984/04 - 1998/03 Kyoto University
- 1986/02 - 1988/01 National Institute of Health (U.S.) National Institute on Heart, Lung and Blood Institute Visiting Fellow
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