Rchr
J-GLOBAL ID：200901001433370079
Update date: Jan. 31, 2024
Yoshiko Yuji
ヨシコ ユウジ | Yoshiko Yuji
Affiliation and department：
Job title：
Professor
Research field (3)：
Oral medicine
, Orthopedics
, Developmental dentistry
Research keywords (7)：
bone formation
, Mineralization/calcification
, 骨粗鬆症
, 骨転移
, miRNA
, 骨代謝
, リン代謝
Research theme for competitive and other funds (21)：
- 2021 - 2024 乳歯歯髄幹細胞由来エクソソームの機能解析と顎裂部骨再生誘導への応用
- 2021 - 2024 クロマチンと遺伝子発現の網羅的解析の併用による組織特異的石灰化機序の同定
- 2021 - 2024 一細胞遺伝子発現プロファイルに基づく骨芽細胞系譜の分化多様性機構の解明
- 2020 - 2023 miR-125bを導入した基質小胞による癌骨転移治療の検討
- 2017 - 2022 Elucidation of the mechanism of osteoblast fate regulation by single cell analysis and search for target molecules of novel osteogenesis-promoting agents
- 2018 - 2021 Elucidation of osteoblast fate determination by single cell analysis on mRNA-ncRNA
- 2017 - 2021 Functional analysis of a novel soluble FGF receptor from bone and cartilage and application to osteochondral regeneration
- 2016 - 2019 A trial of miRNAs derived from bone matrix as an inhibitor for bone metastasis
- 2015 - 2018 The mechanism of regulation by estrogen and estrogen target factors to osteoclastic apoptosis and bone resorption
- 2014 - 2017 Development of bone regeneration strategies by controlling the epigenetic state of bone lining cells.
- 2013 - 2016 The roles of downstream factor(s) of cancer cell-derived Klotho on bone mineralization
- 2011 - 2013 Study of the FGF23-soluble Klotho axis in bone and dental diseases.
- 2011 - 2012 A basic study of de novo function of PTH in mineral metabolism disorders
- 2008 - 2010 A basic study on FGF23 for molecular targeted therapy of bone/tooth diseases
- 2006 - 2007 Basic research for phosphaturic factors including FGF23 as molecular targets for clinical applications.
- 2005 - 2006 Association of aberrant receptor tyrosine kinase signaling pathways in malignant transformation of endothelial cells
- 2004 - 2005 Basic studies of a gene therapy approach for osteoblastic (odontoblastic) disability in inherited and tumor-induced hypophosphatemic disorders
- 2001 - 2002 象牙質形成/骨形成異常と象牙芽細胞/骨芽細胞のリン酸代謝との関係 -とくにX連鎖性低リン酸性ビタミンD抵抗性くる病の原因遺伝子PHEXとナトリウム/リン酸共運搬体によるリン酸代謝について-
- 1998 - 1999 study on the development, aging and the regulation factors of the maintenance of the masticatory organs
- 1996 - 1997 エストロゲンによる骨格筋の老化予防に関する研究
- 1995 - 1995 阻嚼筋の細胞分化・成長におけるエストロゲンおよびアンドロゲンの作用
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Papers (76)：
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Hirotaka Yoshioka, Kazuko Kagawa, Tomoko Minamizaki, Masashi Nakano, Jane E Aubin, Katsuyuki Kozai, Kazuhiro Tsuga, Yuji Yoshiko. Developmental impairments of craniofacial bone and cartilage in transgenic mice expressing FGF10. Bone reports. 2023. 18. 101692-101692
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Davood Kharaghani, Shohei Kohno, Tomoko Minamizaki, Tomonori Hoshino, Yuji Yoshiko. 2,3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells. Colloids and Interface Science Communications. 2022. 50
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Faisal Ahmed, Tomoko Minamizaki, Shohei Kohno, Jane E. Aubin, Davood Kharaghani, Tomonori Hoshino, Yuji Yoshiko. Large Scale Analysis of Osteocyte Lacunae in Klotho Hypomorphic Mice Using High-Resolution Micro-Computed Tomography. SSRN Electronic Journal. 2022
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Occlusal Trauma and Bisphosphonate-Related Osteonecrosis of the Jaw in Mice. Calcif Tissue Int. 2021
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Shota Ito, Tomoko Minamizaki, Shohei Kohno, Yusuke Sotomaru, Yoshiaki Kitaura, Shinsuke Ohba, Toshie Sugiyama, Jane E Aubin, Kotaro Tanimoto, Yuji Yoshiko. Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation. International journal of molecular sciences. 2021. 22. 13
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MISC (8)：
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Faisal Ahmed, Tomoko Minamizaki, Shota Ito, Nushrat Sarmin, Chise Fujimoto, Yuko Nakao, Kotaro Tanimoto, Shinji Hiyama, Yuji Yoshiko. MicroRNA-125b Derived from Osteoblasts Exerts its Anti-Osteolytic Effect through Targeting Preosteoclasts. JOURNAL OF BONE AND MINERAL RESEARCH. 2017. 32. S111-S111
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入江 泰正, 南崎 朋子, 中尾 裕子, Ahmed Faisal, 吉岡 広陽, 香西 克之, 竹井 悠一郎, 吉子 裕二, 谷本 幸太郎. 骨芽細胞は基質小胞を介してmiR-125bを輸送し、Prdm1を標的として破骨細胞の形成を抑制する. 日本骨代謝学会学術集会プログラム抄録集. 2016. 34回. 221-221
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南崎 朋子, 吉岡 広陽, 竹井 悠一郎, 吉子 裕二. 骨量減少・骨髄の脂肪化と糖・脂質代謝メディエーターFGF21/βKlothoの関連について. Journal of Oral Biosciences Supplement. 2015. 2015. 418-418
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南崎 朋子, 吉岡 広陽, 竹井 悠一郎, 吉子 裕二. 骨を対象としたイメージング質量分析の検討. 日本骨代謝学会学術集会プログラム抄録集. 2015. 33回. 209-209
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Yoko Fujino, Tomoko Minamizaki, Kaoru Sakurai, Yasumasa Irie, Hirotaka Yoshioka, Yuichiro Takei, Katsuyuki Kozai, Mitsugi Okada, Yuji Yoshiko. Imaging Mass Spectrometry-based Molecular Histology of Bone Shows the Implication of MEPE-ASARM for the Klotho-Deficient Phenotype. JOURNAL OF BONE AND MINERAL RESEARCH. 2013. 28
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Books (3)：
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歯界展望
医歯薬出版株式会社 2018
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リンの事典
朝倉書店 2017
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The BONE
2004
Lectures and oral presentations (71)：
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High-resolution micro-computed tomography analysis of the microarchitecture in Klotho mutant mouse osteocyte lacunae.
(2021)
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基質小胞を介して骨基質に蓄積されたmiR-125bは2つの経路を介して溶骨性骨転移を抑制する
(2020)
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骨微小環境における骨基質miR-125bの役割
(第62回歯科基礎医学会学術大会 2020)
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Overexpressing miR-125b in Osteoblasts Confers a Significant Survival Benefit in Mice with Bone Metastasis
(ASBMR2020 2020)
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骨基質miR-125bによる骨代謝制御
(2020)
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Professional career (2)：
- Doctor of Philosophy in Dental Science (Hiroshima University)
- Master of Agriculture (Niigata University)
Awards (3)：
- 2007/09 - American Society of Bone and Mineral Research ASBMR Travel Award 1,25(OH)2D3 inhibits bone nodule mineralization through the FGF23-mediating ERK pathway in rat calvaria osteoblast caltures
- 2007/06 - International Bone and Mineral Society IBMS Travel Grants Gene expression profiling of FGF23-overexpressing, mineralization-defective rat calvaria osteoblasts uncovers both known and novel mineralization mechanisms
- 第23回SCRP日本代表選抜大会優勝(ファカルティアドバイザー)
Association Membership(s) (5)：
歯科基礎医学会
, 日本骨代謝学会
, 日本解剖学会
, The European Calcified Tissue Society
, The American Society for Bone and Mineral Research
