Rchr
J-GLOBAL ID：200901001658530679   Update date: Apr. 12, 2024

Kohno Takashi

コウノ タカシ | Kohno Takashi
Affiliation and department：
National Cancer Center, Research Institute Division of Genome Biology

About National Cancer Center, Research Institute Division of Genome Biology


Job title： Chief
Homepage URL  (1)： http://www.ncc.go.jp/en/nccri/divisions/genome_biology/genome_biology.html
Research field  (1)： Pathobiochemistry
Research keywords  (8)： 肺がん ,  がん感受性 ,  遺伝子融合 ,  がん個別化治療 ,  lung cancer ,  cancer susceptibility ,  Gene fusion ,  Precision medicine
Research theme for competitive and other funds  (26)：
  • 2022 - 2025 肺肉腫様癌に対するPD-1阻害薬治療の最適化と耐性機序の解明
  • 2021 - 2024 Development study on pathological predictive biomarkers for cancer treatment
  • 2020 - 2024 Identification of novel driver genes by whole genome sequencing of early stage lung tumors
  • 2017 - 2022 Association of immune responses with racial differences of cancer development
  • 2018 - 2020 Prediction of timing of driver mutation and distant metastasis in lung adenocarcinoma
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Papers (404)：
  • Jun Miyakoshi, Tatsuya Yoshida, Jumpei Kashima, Masayuki Shirasawa, Masahiro Torasawa, Yuji Matsumoto, Ken Masuda, Yuki Shinno, Yusuke Okuma, Yasushi Goto, et al. Clinical significance of inter-assay discrepancy in PD-L1 evaluation for the efficacy of pembrolizumab in advanced NSCLC with high PD-L1 expression. Lung cancer (Amsterdam, Netherlands). 2024. 191. 107788-107788
  • Ken Takasawa, Ken Asada, Syuzo Kaneko, Kouya Shiraishi, Hidenori Machino, Satoshi Takahashi, Norio Shinkai, Nobuji Kouno, Kazuma Kobayashi, Masaaki Komatsu, et al. Advances in cancer DNA methylation analysis with methPLIER: use of non-negative matrix factorization and knowledge-based constraints to enhance biological interpretability. Experimental & Molecular Medicine. 2024
  • Mayumi Kobayashi Kato, Erisa Fujii, Yuka Asami, Yukihide Momozawa, Kengo Hiranuma, Masaaki Komatsu, Ryuji Hamamoto, Takahiro Ebata, Koji Matsumoto, Mitsuya Ishikawa, et al. Clinical features and impact of p53 status on sporadic mismatch repair deficiency and Lynch syndrome in uterine cancer. Cancer Science. 2024
  • Akifumi Mochizuki, Kouya Shiraishi, Takayuki Honda, Ryoko Inaba Higashiyama, Kuniko Sunami, Maiko Matsuda, Yoko Shimada, Yasunari Miyazaki, Yukihiro Yoshida, Shun-ichi Watanabe, et al. Passive smoking-induced mutagenesis as a promoter of lung carcinogenesis. Journal of Thoracic Oncology. 2024
  • Yasuhiko Haga, Yoshitaka Sakamoto, Keiko Kajiya, Hitomi Kawai, Miho Oka, Noriko Motoi, Masayuki Shirasawa, Masaya Yotsukura, Shun-Ichi Watanabe, Miyuki Arai, et al. Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma. Nature communications. 2023. 14. 1. 8375-8375
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MISC (227)：
  • Junya Tabata, Takashi Nakaoku, Kosuke Maruyama, Shigenari Nukaga, Ayako Ui, Takashi Kohno. Identification of novel druggable mutations of RET kinase -Novel activation mode of RET kinase protein-. CANCER SCIENCE. 2022. 113. 684-684
  • Kosuke Maruyama, Takashi Nakaoku, Junya Tabata, Shigenari Nukaga, Takashi Kohno. Development of a drug response model: prediction of RET TKIs sensitivity using MD simulation. CANCER SCIENCE. 2022. 113. 923-923
  • Takashi Nakaoku, Junya Tabata, Kosuke Maruyama, Takashi Kohno. Annotation of variants of unknown significance on RET for precision oncology. CANCER SCIENCE. 2022. 113. 368-368
  • 浜本 純子, 安田 浩之, 石岡 宏太, 寺井 秀樹, 江本 桂, 三牧 幸代, 荒井 大輔, 増澤 啓太, 川田 一郎, 猶木 克彦, et al. 肺腺癌の小細胞癌転化にFGF9が関与する. 日本癌学会総会記事. 2021. 80回. [P14-7]
  • 浜本 純子, 安田 浩之, 石岡 宏太, 寺井 秀樹, 江本 桂, 三牧 幸代, 荒井 大輔, 増澤 啓太, 川田 一郎, 猶木 克彦, et al. 肺腺癌の小細胞癌転化にFGF9が関与する. 日本癌学会総会記事. 2021. 80回. [P14-7]
ｍore...
Patents (1)：
  • KIF5B遺伝子とRET遺伝子との融合遺伝子、並びに該融合遺伝子を標的としたがん治療の有効性を判定する方法
Education (4)：
  • Kyoto University Faculty of Pharmaceutical Sciences
  • 東京大学大学院
  • Kyoto University
  • Graduate School, University of Tokyo
Professional career (2)：
  • Medical Doctor
  • 医学博士 (東京大学)
Work history (7)：
  • 2010/11 - 現在 国立がん研究センター研究所 ゲノム生物学研究分野 分野長
  • 2000 - 2010 国立がんセンター研究所 生物学部 室長
  • 2010 - - 国立がん研究センター研究所 ゲノム生物学研究分野 分野長
  • 1995 - 2000 国立がんセンター研究所 生物学部 研究員
  • 1995 - 2000 Researcher, Biology Division,
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Committee career (2)：
  • 日本癌学会 評議員
  • 日本癌学会評議員
Awards (3)：
  • 2020/06 - 公益財団法人 小林がん学術振興会 小林がん学術賞 本邦のがんゲノム医療の発展に資する治療標的分子・診断手法の実装
  • 2018/09 - International Academy for Advanced Oncology (IAAO) JCA-CHAAO Award
  • 2004 - Japanese Cancer Association (JCA) Incitement Award of the Japanese Cancer Association
Association Membership(s) (5)：
日本癌学会 ,  日本分子生物学会 ,  The Molecular Biology Society of Japan ,  The Japanese Cancer Association ,  The Japan Society of Human Genetics
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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