Rchr

J-GLOBAL ID：200901001794809709 Update date: Apr. 22, 2024

Tanokura Masaru

タノクラマサル | Tanokura Masaru

Affiliation and department：
Homepage URL (1)： http://park.itc.u-tokyo.ac.jp/Yojokun/

Research field (3)： Food sciences , Biophysics , Structural biochemistry

Research keywords (6)：食品科学 , 生物物理学 , 構造生物化学 , Food Science , Biophysics , Structured Biochemistry

Research theme for competitive and other funds (51)：

2018 - 2021 Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism
2015 - 2019 Neuronal differentiation of MUSE cells mediated by neuronal differentiation control peptides and application to neuronal regeneration medicine
2015 - 2018 Sperm recognition domain in mammalian egg coat matrix
2015 - 2018 Mechanism of effectof XOR inhibitors on delay of progress of neurodegenerative diseases
2016 - 2017 Analysis of age-related metabolic changes in mitochondria of Caenorhabditis elegans

2013 - 2016 Mechanisms for acquiring ability to degrade novel compounds in sphingomonads and their applications

2013 - 2016 Regulatory mechanism of ciliary functions by calaxin

2011 - 2016 Elucidation of aging regulatory mechanisms related to mitochondrial function and identification of anti-aging food factors

2012 - 2015 Sperm recognition domain in mammalian egg coat matrix

2012 - 2013 NMRを用いたメタボロミクス分析法の開発及び応用

2010 - 2012 Studies on molecular mechanisms for functional evolution of bacteria in the environment

2009 - 2011 Sperm recognition and matrix formation mechanisms of mammalian egg coats

2004 - 2006 ANALYSIS OF GENES AND PROTEINS RELATED TO COCHLEAR DAMAGE USING DNA MICROARRAY AND PROTEOMICS

2001 - 2005 Investigation of immuno-regulatory competency of dietary substances and its application for our own beneficial ends

2003 - 2004 New Methods for Measuring Heteronuclear Long Range Coupling Constants and Proton-Proton Coupling Constants

2003 - 2004 Improvement of Functions of Novel Enzymes in the Desulfurization Metaoblism of Petroleum by Protein Engineering and Molecular Genetics

2003 - 2004 Three dimensional structures of HCE and LCE and its mechanism of egg envelope digestion

2003 - 2003 WWドメインの機能と特異性に関する総合理解を目指した構造構能相関研究

2001 - 2003 Analysis of structure-function correlation of oryzacystatin and development of new functional foods

1998 - 2003 Structural Biology of Biological Machineries through X-ray Protein Crystallography Reinforced by Synchrotron Radiation

2001 - 2002 Development of the ^<31>P-NMR Probe with ultra high sensitivity and analysis of phosphate binding proteins, related to signal transduction

1999 - 2002 発光細菌の発光反応関連酵素群のX線結晶構造解析

1999 - 2000 X-Ray Crystallography of Flavin Reductase and Its Mutants

2000 - NMRによる食品の非破壊分析

1997 - 1999 Analysis of structure-function relationships on smooth muscle myosin using NMR and X-ray crystallography.

1998 - 1998 ブロメラインインヒビターの3次元構造解析とそれに基づく阻害剤の開発

1998 - 1998 X線とNMRによるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析

1997 - 1997 キネシンとncdのNMRによる動的構造の解析

1997 - 1997 ブロメラインインヒビターの3次元構造解析とそれに基づく阻害剤の開発

1997 - 1997 NMRとX線によるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析

1993 - 1997 Millisecond Order Dynamics of Protein Crystal Structure Using Syncrotron Radiation.

1996 - 1996 NMRとX線によるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析

1993 - 1996 時間分割ラウエ法利用研究

1995 - 1995 NMRとX線小角散乱によるクロコウジカビ酸性プロテアーゼAの折れたたみ機構の解析

1994 - 1994 大腸菌ATP依存性プロテアーゼLonの構造と機能

1993 - 1994 Three-dimensional structural analysis of non-pepsin-type acid proteinase using NMR and x-ray crystaliography

1993 - 1994 Studies on Carboxyl Proteinases : Comparative Analysis of Functional Structures and Catalytic Mechanisms of Proctases A and B

1991 - 1991 りん核磁気共鳴法によるアクトミオシン反応中間体の立体構造の研究

1990 - 1991 Studies on the molecular properties and the structure-function relationships of carboxyl proteases of novel type

1989 - 1990 Conformation of Contractile Protein in its Transition State as Studied by Phosphorus-31 Nuclear Magnetic Resonance

1987 - 1989 Correlations between the mechanical and biochemical processes of muscle contraction by photogeneration of ATP.

立体構造に基づいた新しい機能を持ったタンパク質の創製

芳香族ニトロ(NO2)化合物分解酵素の応用

立体構造に基づいた新機能性タンパク質の創製

タンパク質のX線結晶構造解析

X-ray crystallography of proteins

Design and production of proteins with novel functions on the basis of three-dimensional structures

Application of enzymes to break down aromatic nitro compounds

Design and production of novel functional proteins based on 3D structure

NMR Study of Protein Conformation in Solution

Protein Crystallography

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Papers (391)：

Keiko Shibata, Harune Moriizumi, Koji Onomoto, Yuka Kaneko, Takuya Miyakawa, Shuhei Zenno, Masaru Tanokura, Mitsutoshi Yoneyama, Tomoko Takahashi, Kumiko Ui-Tei. Caspase-mediated processing of TRBP regulates apoptosis during viral infection. Nucleic Acids Research. 2024
Ryo Tachibana, Susumu Abe, Momo Marugami, Ayumi Yamagami, Rino Akema, Takao Ohashi, Kaisei Nishida, Shohei Nosaki, Takuya Miyakawa, Masaru Tanokura, et al. BPG4 regulates chloroplast development and homeostasis by suppressing GLK transcription factors and involving light and brassinosteroid signaling. Nature Communications. 2024. 15. 1
Takafumi Hashimoto, Kenji Hashimoto, Hiroki Shindo, Shoko Tsuboyama, Takuya Miyakawa, Masaru Tanokura, Kazuyuki Kuchitsu. Enhanced Ca2+ binding to EF-hands through phosphorylation of conserved serine residues activates MpRBOHB and chitin-triggered ROS production. Physiologia Plantarum. 2023. 175. 6. e14101
Satoshi Yamanaka, Hirotake Furihata, Yuta Yanagihara, Akihito Taya, Takato Nagasaka, Mai Usui, Koya Nagaoka, Yuki Shoya, Kohei Nishino, Shuhei Yoshida, et al. Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation. Nature communications. 2023. 14. 1. 4683-4683
Satoshi Kidokoro, Izumi Konoura, Fumiyuki Soma, Takamasa Suzuki, Takuya Miyakawa, Masaru Tanokura, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki. Clock-regulated coactivators selectively control gene expression in response to different temperature stress conditions in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 16. e2216183120

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MISC (479)：

降旗大岳, 山中聡士, 本田敏章, 柴田哲男, 田之倉優, 澤崎達也, 宮川拓也. Structural bases for the degradation selectivity of C2H2 zinc finger by thalidomide metabolite. 量子ビームサイエンスフェスタ(Web). 2021. 2020
楠林和貴, 宮園健一, 伊藤友子, 栗崎晃, 田之倉優. TGF-βシグナル主要伝達因子SMAD2及びSMAD3のMH2ドメインにおける性状比較. 日本生化学会大会(Web). 2020. 93rd
楠林和貴, 宮園健一, 伊藤友子, 栗崎晃, 栗崎晃, 浅島誠, 田之倉優. Characteristics of MH2 domains of SMAD2 and SMAD3 in TGF-β signaling. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
降旗大岳, 山中聡士, 本田敏章, 柴田哲男, 田之倉優, 澤崎達也, 宮川拓也. サリドマイド代謝物によるC2H2型ZFの分解選択性の構造基盤. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
関真太郎, 喜久里貢, 今村優作, 高橋郁夫, 福井康祐, 福井康祐, XU Yuqun, 宮川拓也, 田之倉優, 中村英光, et al. Functional analyses and inhibitor screening of strigolactone-receptor homologues in the parasitic plant Striga. 日本農薬学会大会講演要旨集. 2020. 45th

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Patents (5)：

タンパク質結晶化方法
平滑筋弛緩剤とその有効成分の抽出方法
蛋白質の分離方法
ザルコシン・オキシダーゼの結晶, その製造方法及び三次元構造
リコンビナントMPOフラグメント及びそれを用いたMPO自己抗体の測定法.

Books (48)：

4.8 発生と分化. 入門構造生物学-放射光X線と中性子で最新の生命現象を読み解く-(高エネルギー加速器研究機構構造生物学研究センター編加藤龍一編集)165-172
共立出版, 東京 2010
Effects of functional antioxidants on age-related hearing loss. Biotechnology in Functional Foods and Nutraceuticals
CRC Press, U. S. A. 2010
老人性難聴におけるBak 依存性ミトコンドリアアポトーシスの役割
実験医学 28 (6), 917-920 2010
Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys.
Curr. Aging Sci. 3 (1), 20-25. 2010
近年の酵素・タンパク質結晶構造解析の進歩と展開
日本結晶学会誌 52 (1), 8-13. 2010

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Works (13)：

創薬等支援技術基盤プラットフォーム
2012 - 現在
ターゲットタンパク研究プログラム
2007 - 2011
ターゲットタンパク研究プログラム「キラル化合物の産業生産に有用な酵素の触媒反応機構の解明と高機能化」
2007 - 2011
ターゲットタンパク研究プログラム「乾燥・高温ストレス耐性作物の開発に役立つ転写制御タンパク質の構造・機能解析」
2007 - 2011
タンパク3000プロジェクト「発生・分化とDNAの複製・修復」
2002 - 2006

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Education (4)：

- 1979 The University of Tokyo
- 1979 The University of Tokyo Graduate School, Division of Science
- 1975 The University of Tokyo Faculty of Science
- 1974 The University of Tokyo Faculty of Science

Professional career (2)：

Master of Science (The University of Tokyo)
Ph.D. (The University of Tokyo)

Work history (13)：

2017/06 - 現在 The University of Tokyo Professor Emeritus
2017/04 - 現在 The University of Tokyo Graduate School of Agricultural and Life Sciences Project Professor
1998/08 - 2017/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Professor
1994/03 - 1998/07 The University of Tokyo Biotechnology Research Center Professor
1994 - 1998 Professor, University of Tokyo, Biotechnology Research Center

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Committee career (8)：

2012/03 - 現在日本農芸化学会関東支部参与
2004/10 - 現在日本食品免疫学会評議員
1996/10 - 現在日本生化学会評議員
2011/10 - 2013/09 日本生化学会理事
2009/01 - 2011/12 日本バイオイメージング学会会長

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Association Membership(s) (11)：

日本蛋白質科学会 , American Society of Biochemistry and Molecular Biology , Biophysical Society , American Crystallographic Association , Protein Society , 日本動物細胞工学会 , 日本バイオイメージング学会 , 日本生物物理学会 , 日本農芸化学会 , 日本生化学会 , Biophysical society

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