Mizumoto Shuji

ミズモトシュウジ | Mizumoto Shuji

Affiliation and department：
Job title：准教授
Homepage URL (1)： https://scholar.google.co.jp/citations?hl=ja&user=b0ZTepcAAAAJ

Research field (8)： Genetics , Genomics , Pathobiochemistry , Developmental biology , Molecular biology , Pharmaceuticals - health and biochemistry , Cell biology , Structural biochemistry

Research keywords (25)：フィラミン , 糖鎖医学 , 糖鎖病態学 , RAGE , がん転移 , 神経・免疫・骨格異常症候群 , 脊椎骨端骨幹端異形性症 , エーラス・ダンロス症候群 , 遺伝病 , 結合組織疾患 , 皮膚疾患 , 骨系統疾患 , 包括脳ネットワーク , ヘパラン硫酸 , デルマタン硫酸 , コンドロイチン硫酸 , グリコサミノグリカン , プロテオグリカン , zebrafish , heparin , heparan sulfate , dermatan sulfate , chondroitin sulfate , glycosaminoglycan , proteoglycan

Research theme for competitive and other funds (11)：

2019 - 2022 プロテオグリカンとフィラミンのクロストークとその変異による遺伝性骨疾患
2019 - 2021 Crosstalk of chondroitin sulfate and filamin in hereditary bone dyaplasias
2018 - 2020 RAGEが関わる糖尿病合併症におけるグリコサミノグリカンの役割とその阻害効果
2016 - 2019 Golginによるグリコサミノグリカン生合成調節機構と遺伝性骨・皮膚疾患との関連
2016 - 2018 糖鎖合成異常に基づく遺伝性の骨・皮膚疾患の糖鎖結合タンパク質の同定と発症機序の解明

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Papers (96)：

Lin Wang, Shuji Mizumoto, Ruixue Zhang, Yuqi Zhang, Yuan Liu, Wenjing Cheng, Xin Li, Min Dan, Chunyan Zhang, Xinru Gao, et al. Identification of a novel LFNG variant in a Chinese fetus with spondylocostal dysostosis and a systematic review. Journal of Human Genetics. 2024. in press
Hayato Ota, Hirokazu Sato, Shuji Mizumoto, Ken Wakai, Kei Yoneda, Kazuo Yamamoto, Hayao Nakanishi, Jun-Ichiro Ikeda, Shinichi Sakamoto, Tomohiko Ichikawa, et al. Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer. Scientific Reports. 2023. 13. 1. 11618
Soichiro Saito, Shuji Mizumoto, Tsukasa Yonekura, Rina Yamashita, Kenta Nakano, Tadashi Okubo, Shuhei Yamada, Tadashi Okamura, Tatsuya Furuichi. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. PLoS One. 2023. 18. 4. e0284292
Shuji Mizumoto, Shuhei Yamad. Histories of Dermatan Sulfate Epimerase and Dermatan 4-O-Sulfotransferase from Discovery of Their Enzymes and Genes to Musculocontractural Ehlers-Danlos Syndrome. Genes. 2023. 14. 2. 509
Ayana Hashimoto, Takuya Hirose, Kohei Hashimoto, Shuji Mizumoto, Yuko Nitahara-Kasahara, Shota Saka, Takahiro Yoshizawa, Takashi Okada, Shuhei Yamada, Tomoki Kosho, et al. Collagen network formation in in vitro models of musculocontractural Ehlers-Danlos syndrome. Genes. 2023. 14. 2. 308

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Patents (2)：

グリコサミノグリカン分解促進剤
ムコ多糖分解促進剤

Books (21)：

Biochemistry in New Direction
Kyoto Hirokawa 2023
Editorial: Roles of Chondroitin Sulfate and Dermatan Sulfate as Regulators for Cell and Tissue Development
Frontiers in Cell and Developmental Biology, 10, 941178 2022
Memories of Professor Kazuyuki Sugahara
Trends in Glycoscience and Glycotechnology, Vol 33, No. 192, J49 (E49-E50) 2021
コラム11 プロテオグリカンと病気
糖鎖生物学 (生命現象と糖鎖情報), 編集:北島健、佐藤ちひろ、門松健治、加藤晃一, 名古屋大学出版会, pp. 268-272 2020
Hereditary skeletal and skin disorders caused by defects in biosynthesis of chondroitin/dermatan sulfate, and molecular mechanism of pulmonary metastasis
YAKUGAKU ZASSHI, 139 (12), pp.1495-1500 2019

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Lectures and oral presentations (103)：

Effect of uridine diphosphate on the enzymatic activities of UDP-GlcA decarboxylase, xylosyltransferase, and glucuronyltransferase
(2023 Annual Meeting Society for Glycobiology 2023)
Effect of uridine diphosphate on the enzymatic activities of UDP-GlcA decarboxylase, xylosyltransferase, and glucuronyltransferase
(2023)
Analyses of hereditary disorders caused by defects in biosynthesis of chondroitin/dermatan/heparan sulfate
(89th Harden Conference - Proteoglycans: Matrix Master Regulators 2023/12th International Conference on Proteoglycans 2023)
Effect on the enzymatic activity of xylosyltransferases by their amino acid substitutions causing Desbuquois dysplasia and spondyloocular syndrome
(The 143rd Annual Meeting of the Pharmaceutical Society of Japan 2023)
Congenital skeletal, skin, neuronal, and immunological disorders caused by defect in side chains of proteoglycans
(The 5th Seminar on Research Center for Pathogenesis of Intractable Diseases 2023)

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Professional career (1)：

Ph.D.

Work history (9)：

2019/04 - 現在 Meijo University Graduate School/Faculty of Pharmacy Associate Professor
2013/10 - 2019/03 Meijo University Faculty of Pharmacy
2017/04 - 2018/03 University of Otago, Dunedin School of Medicine, Department of Women’s and Children’s Health, Clinical Genetics Group (Stephen Robertson’s Lab) Visiting Researcher
2012/04 - 2013/09 新学術領域研究・神経糖鎖生物学 (文科省) 博士研究員
2010/04 - 2013/09 未来創薬・医療イノベーション拠点形成 (文科省イノベーションシステム整備事業) 博士研究員

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Committee career (10)：

2022/07 - 現在 Frontiers in Molecular Bioscience (Section for Glycoscience) Associate Editor
2020/07 - 現在 Genes (Section for Human Genomics and Genetic Diseases) Editorial Board member
2020/01 - 現在 Associate Editor
2020/01 - 現在 Associate Secretary
2023/01 - 2023/01 糖鎖科学中部拠点第18回若手の力フォーラム世話人

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Awards (3)：

2018/06 - 日本薬学会東海支部日本薬学会東海支部学術奨励賞コンドロイチン/デルマタン硫酸の生合成不全による遺伝性の骨・皮膚疾患と肺癌転移の分子メカニズム
2016/09 - The Japanese Society of Carbohydrate Research Research Award for Japanese Society of Carbohydrate Research Glycobiological approaches for bone and skin disorders caused by deficiency of glycosaminoglycans and its role for tumor metastasis
2015/08 - 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium Travel Award

Association Membership(s) (11)：

The Japanese Society of Bone and Mineral Research , The American Society for Biochemistry and Molecular Biology (U.S.A.) , The Japan Society of Human Genetics , The Japanese Society of Cartilage Metabolism , Society for Glycobiology (U.S.A.) , The Japanese Society for Matrix Biology and Medicine , The Molecular Biology Society of Japan , The Pharmaceutical Society of Japan , The Japanese Biochemical Society , Forum: Carbohydrate Coming of Age (FCCA) , The Japanese Society of Carbohydrate Research

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