Rchr
J-GLOBAL ID：200901001878032041
Update date: Apr. 19, 2024
Nakanishi Toyofumi
ナカニシ トヨフミ | Nakanishi Toyofumi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://ims-3d.kenkyuukai.jp/about/
Research field (1)：
Pathobiochemistry
Research keywords (6)：
毛髪縦断面/FFPE標本/新鮮凍結組織IMS解析
, アミロイド原性獲得機序の解明と予防法開発
, 臨床プロテオミクス/Autoantibodiomics
, 3次元質量イメージング解析
, 検査診断学
, Clinical Pathology
Research theme for competitive and other funds (25)：
- 2019 - 2022 Identifications of pancreatic cancer specific neo-antigens with the autoantibodiomics and verifications of diagnostic utilities of its autoantibody screening to neo-antigens
- 2013 - 2016 Identifications of abnormal modified proteins localized in amyloid tissues by MALDI-imaging and clarification of formation of amyloid fibril
- 2012 - 2015 Search of oxidized protein involved in the mechanism of central nervous system impairment of Down syndrome model Ts65Dn mouse
- 2012 - 2015 Profile analysis of disease-related markers in synovial tissues of rheumatoid arthritis using imaging mass spectrometry
- 2012 - 2015 Mass spectrometry imaging of single hair specimens for the reliable chronological estimation of drug abuse, and for the investigation of the mechanism of drug incorporation into hair
- 2010 - 2013 Investigation of the molecular mechanism of the radical reaction to induce the amyloid fibril derived from the transthyretin
- 2009 - 2011 Identifications of tentative pancreatic cancer-related antigens of expressed proteins derived from membrane and nuclei components of 4 pancreatic cancer cell lines by autoantibodiomics
- 2008 - 2010 質量顕微鏡によるアミロイド組織内沈着分子プロフィル異常と線維形成阻止法の開発
- 2008 - 2010 Detection of Disease-related Proteins in Dermatomyositis Associated with Interstitial Pneumonia by Proteomics-based Analysis
- 2007 - 2009 Identifications of non-Hodgkin's lymphoma (NHL)-specific antigens bounded with autoantibodies in plasma derived from patients with NHL by an autoantibodiomics
- 2007 - 2008 Identify new insulin mimicking molecules from serum of fulminant type 1 diabetes
- 2005 - 2007 Identifications of diagnostic biomarkers specific binding to soluble proteins of adenocarcinoma A 549 cell lines by an autoantibodiomics
- 2004 - 2006 Analysis of modified structures of transthyretin, elucidation of disease etiology of amyloidosis and application to clinical laboratory tests
- 2006 - 2006 プロテオミクスによる膵癌特異抗原に対する新規自己抗体の同定
- 2005 - 2006 Proteomics-based approach identifying autoantibodies in Behcet's disease
- 2002 - 2004 Expression proteomics of angiogenesis-modulated factors in human vitreous humors derived from diabetic retinopathy
- 2002 - 2004 Elucidation of the fine structure and the generation process of modified proteins (sulfonate, nitroso, et al.) application to clinical laboratory test
- 1999 - 2002 The quantification of ratios between apo to holo types of metal binding protein : a new indicator of the oxidative stress in cells
- 2001 - 2002 トランスサイレチン関連アミロイドーシスにおける繊維化分子機構の解明
- 1999 - 2001 B cell clone proliferated in HCV infection and V regeon structure of RF correlated to complement clod activation
- 1997 - 2000 Establishment and practical use of reference method for glyco-haemoglobin by mass spectrometry
- 1998 - 2000 神経疾患の原因となる変異蛋白質の質量分析による検出と構造決定および新診断法の確立
- 1996 - 1998 金被覆ミクロキャピラリーLC装着質量分析による癌特異ペプチドの超高感度構造決定
- 1996 - 1998 Elucidation of complement cold activation and cryoglobulin formation associated with HCV infection.
- 1994 - 1995 Study of the mechanism of in-vitro activation of complement and formation of cryoglobulin in the sera from patients with C type hepatitis
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Papers (102)：
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Kenta Minami, Ryota Masutani, Youichi Suzuki, Meri Kubota, Naofumi Osaka, Toyofumi Nakanishi, Takashi Nakano, Akira Ukimura. Evaluation of SARS-CoV-2 RNA quantification by RT-LAMP compared to RT-qPCR. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2021. 27. 7. 1068-1071
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麻野 秀一, 中西 豊文, 桝谷 亮太, 南 健太, 上田 一仁, 松村 洋子, 大坂 直文. MALDI-TOFMS法による尿中単クローン性免疫グロブリン軽鎖のスクリーニング法の確立. 臨床病理. 2020. 68. 補冊. 141-141
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Okuda Y, Fukumoto M, Horie T, Oku H, Takai S, Nakanishi T, Matsuzaki K, Tsujimoto H, Ikeda T. Periocular injection of candesartan-PLGA microparticles inhibits laser-induced experimental choroidal neovascularization. Clinical Ophthalmology. 2018. 13. 87-93
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Katsuhiro Shiono, Riho Hashizaki, Toyofumi Nakanishi, Tatsuko Sakai, Takushi Yamamoto, Koretsugu Ogata, Ken-ichi Harada, Hajime Ohtani, Hajime Katano, Shu Taira. Multi-imaging of Cytokinin and Abscisic Acid on the Roots of Rice (Oryza sativa) Using Matrix-Assisted Laser Desorption/lonization Mass Spectrometry. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2017. 65. 35. 7624-7628
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Yoshifumi Suwa, Toyofumi Nakanishi, Nahoko Kato-Kogoe, Yoshihiro Kimura, Haruhiko Terai, Yoichiro Nakajima, Akihiro Sunano, Kayoko Yamamoto, Takaaki Ueno. Changes of Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Concentrations in Platelet-rich Plasma After Preparation. JOURNAL OF HARD TISSUE BIOLOGY. 2017. 26. 1. 33-36
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MISC (45)：
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Ishida Takaaki, Kotani Takuya, Tabushi-Matsumura Yoko, Nakanishi Toyofumi, Takeuchi Tohru. ブレオマイシン誘発間質性肺炎モデルマウスに由来する全肺抽出物に含まれていた9種の蛋白質の二次元電気泳動/ゲル内消化/MALDI-TOF MSMS解析法による同定(Identification of nine proteins in whole lung extract derived from bleomycin-induced interstitial pneumonia model mouse by two-dimensional electrophoresis/in-gel digestion/MALDI-TOF MSMS analysis). Medical Mass Spectrometry. 2021. 5. 1. 38-46
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Asano Shuichi, Masutani Ryota, Ueda Kazuhito, Igarashi Kazuo, Nirasawa Takashi, Kubota Meri, Tabushi-Matsumura Yoko, Osaka Naofumi, Nakanishi Toyofumi. 単クローン性ガンマグロブリン血症の患者で免疫グロブリン遊離L鎖のアイソタイプであるκ型とλ型を迅速に識別するために適用したMALDI-TOF MS解析法(Application of MALDI-TOF MS analysis for rapid discrimination of free immunoglobulin light chains, kappa and lambda isotypes in patients with monoclonal immunoglobulin gammopathy). Medical Mass Spectrometry. 2021. 5. 1. 47-54
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Sato Nayuko, Nakanishi Toyofumi, Kasama Takeshi, Takahashi Toshie, Kimura Kosei, Tanaka Satoru, Iwamoto Mitsuhiko, Fujioka Hiroya, Takahashi Yuko, Uchiyama Kazuhisa. 新鮮凍結乳房組織切片における乳癌特異的バイオマーカー候補のMALDIイメージングとon-tissue digestionによる同定(Identifications of Candidate Breast Cancer-Specific Biomarkers in Fresh Frozen Breast Tissue Sections by MALDI-imaging Coupled with on-tissue Digestion). Bulletin of the Osaka Medical College. 2017. 63. 1-2. 1-10
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Upcoming Challenges of Next-Generation Clinical Laboratory Tests with Mass Spectrometric Technique : Chairman's Introductory Remarks. 2016. 64. 6. 667-671
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Sato Nayuko, Nakanishi Toyofumi, Nirasawa Takashi, Uchiyama Kazuhisa, Takubo Takayuki, Caprioli Richard M. MALDI-MSイメージングとMS/MS分析による単一スライスしたヒト網膜組織切片における蛋白発現のクラスタリングとトポロジー(Clustering and Topology of Proteins Expressed in a Single Sliced Human Retina Tissue Section by MALDI-MS Imaging and MS/MS Analysis). Bulletin of the Osaka Medical College. 2014. 60. 1. 35-39
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Patents (3)：
Education (1)：
- - 1980 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences
Professional career (1)：
Work history (10)：
- 2022/04 - 現在 Shubun University Department of Medical Sciences Professor
- 2022/04 - Osaka Medical and Pharmaceutical University
- 2007 - 2022/03 Osaka Medical and Pharmaceutical University
- 2008 - 2009 バンダービルト大学医学部MS解析センター 交換研究員
- 2004 - 2007 Osaka Medical College
- 1996 - 2004 Osaka Medical College
- 1996 - 1997 テキサス大学医学部ヒューストン校分析化学センター 客員教授
- 1992 - 1996 Osaka Medical College
- 1981 - 1992 国立大阪病院(現:(独)国立病院機構大阪医療センター) 厚生技官
- 1989 - 1991 東京都臨床医学研究所臨床遺伝学部門 研修生
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Committee career (11)：
- 2021/09 - 現在 日本医用マススペクトル学会 副理事長
- 2018/04 - 現在 日本医用マススペクトル学会 認定制度委員会 委員長
- 2013/01 - 現在 日本臨床検査自動化学会 遺伝子・プロテオミクス技術委員会 委員アドバイザー
- 2011 - 現在 3次元MSイメージング研究会 代表世話人
- 2004 - 現在 日本臨床プロテオーム学会 理事
- 2002 - 現在 日本臨床検査医学会 評議員
- 1997 - 現在 日本臨床化学会 評議員/集会委員/編集委員
- 1994 - 現在 日本医用マススペクトル学会 評議員/編集委員/理事
- 2003 - 2015 日本電気泳動学会 評議員/理事
- 2010 - 2013 日本質量分析学会 Editorial Advisory Board
- 1999 - 2006 日本質量分析学会 学会誌編集委員
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Awards (6)：
- 2017/09 - Japanese Society of Biomedical Mass Spectrometry Matsumoto's Prize
- 2008 - 日本電気泳動学会 国際交流奨励賞
- 2005 - 日本電気泳動学会 児玉賞
- 2000 - 日本質量分析学会奨励賞
- 1999 - 日本臨床病理学会学会賞
- 1996 - 日本医用マススペクトル学会奨励賞
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Association Membership(s) (8)：
日本臨床検査自動化学会
, アメリカ質量分析学会
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本電気泳動学会
, 日本質量分析学会
, 日本臨床検査医学会
, 日本臨床化学会
, 日本医用マススペクトル学会
