2021 - 2024 Development of ultrasound-responsive nanobubbles specialized on heart failure and construction of a disease treatment system
2020 - 2023 癌細胞の増殖と基質接着を結ぶHER2-CD239複合体の機能解明
2018 - 2021 Development of ultrasound-responsive nanobubbles containing genome editing tools and establishment of disease treatment system
2018 - 2021 Renewal of severely damaged livers by activating hepatic progenitor cells
2017 - 2020 Roles of CD239 on adhesion and migration of tumor cells
2017 - 2019 In vitro reconstruction of hepatic tissue
2016 - 2019 Development of antibody delivery system by ultrasound responsive nano bubble and breast cancer treatment strategy
2014 - 2016 The roles of laminin alpha5 in tumor invasion
2013 - 2015 Development of cell-specific essential peptide matrix (EP-Matrix)
2012 - 2015 Establishment of cell transplantation therapy for hepatic failure by hepatic stem/progenitor cells and/or hepatic organoids
2014 - 2015 上皮管腔組織における基底膜形成メカニズムの解明
2010 - 2014 Molecutar anatomy and medicinal application of laminins, a basement membrane protein
2011 - 2011 Roles of Lutheran in tumor cell adhesion and migration
2009 - 2011 Basic research for the production of human hepatocytes and the transplantation of hepatic tissues
2008 - 2010 Primary culture of hepatocytes on synthetic peptides mimicking the functions of laminin-111
2006 - 2007 ラミニンα5鎖の受容体結合部位とその結合メカニズムの解明
2005 - 2007 Research for the formation of hepatic organoids by using human hepatic progenitor cells and the model of artificial liver device incorporated with human hepatic organoids
2005 - 2007 Role of laminin alpha5 and its receptors in fibrotic liver and hepatocellular carcinoma
2005 - 2006 3次元細胞培養ゲル「ペプチドマトリックス」の創製
2004 - 2004 癌の浸潤・転移に関わるLutheran/B-CAMの研究
2002 - 2004 Identification of specific surface proteins in small hepatocytes and reconstruction of hepatic organoids ex vivo.
1996 - 1997 組織カリクレインファミリ-の新しい生理機能と成長因子前駆体のプロセッシング
1996 - 1996 新しい細胞外マトリックス,ラドシン/ラミニン-5の機能解析
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Papers (130)：
Yusuke Yano, Rui Tada, Nobuhito Hamano, Kenshin Haruta, Tomomi Kobayashi, Masahiro Sato, Yamato Kikkawa, Yoko Endo-Takahashi, Motoyoshi Nomizu, Yoichi Negishi. Development of a concise and reliable method for quantifying the antibody loaded onto lipid nanoparticles modified with Herceptin. Journal of Immunological Methods. 2023. 521. 113554-113554
Masumi Matsunuma, Ryuji Kan, Yuji Yamada, Keisuke Hamada, Motoi Kanagawa, Motoyoshi Nomizu, Yamato Kikkawa. Chain-specificity of laminin α1-5 LG45 modules in the recognition of carbohydrate-linked receptors and intramolecular binding. Scientific reports. 2023. 13. 1. 10430-10430
Keisuke Hamada, Ten Hashimoto, Rinoka Iwashita, Yuji Yamada, Yamato Kikkawa, Motoyoshi Nomizu. Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation. Cell Reports Physical Science. 2023
Yusuke Yano, Nobuhito Hamano, Kenshin Haruta, Tomomi Kobayashi, Masahiro Sato, Yamato Kikkawa, Yoko Endo-Takahashi, Rui Tada, Ryo Suzuki, Kazuo Maruyama, et al. Development of an Antibody Delivery Method for Cancer Treatment by Combining Ultrasound with Therapeutic Antibody-Modified Nanobubbles Using Fc-Binding Polypeptide. Pharmaceutics. 2022. 15. 1. 130-130
2009/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2005/04 - 2009/03 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2003/04 - 2005/03 Sapporo Medical University
2000/12 - 2003/03 Washington Univ. Sch of Med Research Associate
1999/04 - 2000/11 Osaka Women's and Children's Hospital Research Institute
1998/10 - 2000/09 スウェーデン ウプサラ大学、ルンド大学 博士研究員
1996/10 - 1998/09 Osaka Women's and Children's Hospital Research Institute
1995/04 - 1996/10 The University of Tokushima Faculty of Dentistry
1992/04 - 1995/03 Yokohama City University Graduate
1990/04 - 1993/03 金沢大学大学院理学研究科 修士課程
1986/04 - 1990/03 横浜市立大学文理学部生物学科
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Awards (2)：
2010 - 大高賞(結合組織学会奨励賞)
2009 - 水島昭二記念研究賞
Association Membership(s) (7)：
米国細胞生物学会
, 米国マトリックス学会
, 肝細胞研究会
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本結合組織学会
