Nakatsu Yoshimichi

ナカツヨシミチ | Nakatsu Yoshimichi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.med.kyushu-u.ac.jp/biophys/

Research field (4)： Molecular biology , Genetics , Environmental effects of chemicals , Environmental effects of radiation

Research keywords (11)：遺伝子操作マウス , アポトーシス , 突然変異 , 酸化的損傷 , DNA修復 , Transgenic mouse , Knockout mouse , Apoptosis , Mutagenesis , Oxidative damage , DNA repair

Research theme for competitive and other funds (8)：

2001 - 2004 酸化的DNA, RNA障害の抑制機構
2001 - 2004 Avoidance mechanisms of oxidative damage in DNA and RNA.
遺伝子操作マウス作出法の改良
動物個体における突然変異の解析
DNA、RNA、ヌクレオチドプールの障害による細胞死

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Papers (64)：

Yusuke Matsuno, Yuko Atsumi, Atsuhiro Shimizu, Kotoe Katayama, Haruka Fujimori, Mai Hyodo, Yusuke Minakawa, Yoshimichi Nakatsu, Syuzo Kaneko, Ryuji Hamamoto, et al. Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro. Nature communications. 2019. 10. 1. 3925-3925
Genki Hayashida, Seijiro Shioi, Kyoko Hidaka, Ryosuke Fujikane, Masumi Hidaka, Toshiki Tsurimoto, Teruhisa Tsuzuki, Shinya Oda, Yoshimichi Nakatsu. Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing. Experimental Cell Research. 2019. 377. 1-2. 24-35
Yutaka Matsubara, Takuya Matsumoto, Keiji Yoshiya, Ayae Yoshida, Seiichi Ikeda, Tadashi Furuyama, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Masatoshi Nomura, Yoshihiko Maehara. Budding Uninhibited by Benzimidazole-1 Insufficiency Prevents Acute Renal Failure in Severe Sepsis by Maintaining Anticoagulant Functions of Vascular Endothelial Cells. Shock. 2019. 51. 3. 364-371
Tetsuya Suzuki, Yuri Yanai, Natsuki Nishigaki, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Hiroyuki Kamiya. Effects of mismatches distant from the target position on gene correction with a 5′-tailed duplex. Journal of Bioscience and Bioengineering. 2018. 125. 5. 619-623
Issei Egashira, Fumi Takahashi-Yanaga, Risa Nishida, Masaki Arioka, Kazunobu Igawa, Katsuhiko Tomooka, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Yusaku Nakabeppu, Takanari Kitazono, et al. Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/beta-catenin signaling pathway. CANCER SCIENCE. 2017. 108. 1. 108-115

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MISC (13)：

Teruhisa Tsuzuki, Jing Shu Piao, Yoshimichi Nakatsu. [Oxidative DNA damage-induced intestinal tumorigenesis in Mutyh-deficient mice]. Nihon rinsho. Japanese journal of clinical medicine. 2011. 69 Suppl 3. 137-142
Yoshimichi Nakatsu, Mutsuo Sekiguchi. Oxidative damage to nucleotide: Consequences and preventive mechanisms. Oxidative Stress, Disease and Cancer. 2006. 221-252
Errol C Friedberg, Fumio Hanaoka, Kiyoji Tanaka, Samuel H Wilson, Akira Yasui. Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002. DNA repair. 2003. 2. 5. 639-52
Y. Nakatsu. Transcription-coupled repair and Cockayne syndrome. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2001. 46. 8 Suppl. 908-915
Y Enokido, N Inamura, T Araki, T Satoh, H Nakane, M Yoshino, Y Nakatsu, K Tanaka, H Hatanaka. Loss of the xeroderma pigmentosum group A gene (XPA) enhances apoptosis of cultured cerebellar neurons induced by UV but not by low-K+ medium. JOURNAL OF NEUROCHEMISTRY. 1997. 69. 1. 246-251

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Books (2)：

"Oxidative Damage to Nucleotide: Consequences and Preventive" in "MechanismsOxidative Stress, Disease and Cancer"
Imperial College Press 2006
"Oxidative Damage to Nucleotide: Consequences and Preventive" in "MechanismsOxidative Stress, Disease and Cancer"
Imperial College Press 2006

Lectures and oral presentations (55)：

Distinct pathways of apoptosis induced by alkylated DNA damage
(The International Ataxia-Telangiectasia Workshop 2008 2008)
哺乳動物細胞への8-oxo-dGTPの導入はA:T→C:G変異を引き起こす
(第67回日本癌学会学術総会 2008)
Msh2遺伝子欠損マウスにおける酸化ストレス誘発小腸腫瘍の解析
(第67回日本癌学会学術総会 2008)
哺乳動物細胞における8-oxoguanineに起因する突然変異とその防御機構
(日本放射線得影響学会第51回大会 2008)
DNA修復関連遺伝子欠損マウスにおける酸化ストレス誘発消化管発がん
(日本環境変異原学会第37回大会 2008)

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Works (10)：

酸化的DNA損傷による誘発突然変異と発がん
2003 - 現在
酸化的DNA損傷による細胞死誘発機構の研究
2002 - 現在
効率的な遺伝子治療法開発の基盤研究
2002 - 現在
DNA修復欠損マウスの発がん感受性
2001 - 2002
Tumorigenesis in DNA repair deficient mice.
2001 - 2002

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Education (4)：

- 1985 Kyushu University
- 1985 Kyushu University Graduate School, Division of Natural Science Biology
- 1979 Kyushu University School of Sciences Department of Biology
- 1979 Kyushu University Faculty of Science Biology

Professional career (1)：

Doctor of Science (Kyushu University)

Work history (12)：

2007 - 現在 Kyushu University Faculty of Medical Sciences
2001 - 2007 Kyushu University Faculty of Medical Sciences
2000 - 2001 大阪大学細胞生体工学センター助教授
2000 - 2001 Associate Professor, Institute for Molecular and Cellular Biology, Osaka University.
1994 - 2000 大阪大学細胞生体工学センター助手

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Association Membership(s) (8)：

日本放射線影響学会 , 日本癌学会 , 日本遺伝学会 , 日本分子生物学会 , The Genetic Society of Japan , The Japanese Cancer Association , The Japan Radiation Research Society , The Molecular Biology Society of Japan

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