Rchr
J-GLOBAL ID：200901003234129160
Update date: Feb. 01, 2024
Okamura Toshimitsu
オカムラ トシミツ | Okamura Toshimitsu
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Affiliation and department：
National Institutes for Quantum and Radiological Science and Technology
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Research field (1)：
Radiology
Research keywords (2)：
放射性医薬品
, PET
Research theme for competitive and other funds (7)：
2022 - 2025 脳から老廃物を排出するグリンパティックシステムの非侵襲的定量評価法の開発
2019 - 2022 脳内のチオシアン酸イオン排出速度の非侵襲的定量測定法の開発とその排出機構解明
2016 - 2019 脳内NADPHオキシダーゼ活性測定を目的とするPETトレーサの開発
2013 - 2016 脳内レドックス状態のイメージングを目的とするPETプローブの開発
2011 - 2013 末梢組織における異物排出トランスポータ機能のイメージング
2010 - 2011 ヨウ化物イオンの脳内からの排出輸送をダイナミックに捉えるI-124標識イメージング薬剤の開発
2008 - 2010 脳内異物排出システムの非侵襲的定量評価を目的とするプローブおよび測定法の開発
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Papers (29)：
Hideki Ishii, Tomoteru Yamasaki, Toshimitsu Okamura, Yiding Zhang, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Ming-Rong Zhang. Evaluation and improvement of CuI-mediated 11 C-cyanation. Journal of labelled compounds & radiopharmaceuticals. 2023. 66. 3. 95-107
Toshimitsu Okamura, Satoshi Tsukamoto, Maki Okada, Tatsuya Kikuchi, Ryutaro Aizawa, Hidekatsu Wakizaka, Nobuki Nengaki, Masanao Ogawa, Hideki Ishii, Ming-Rong Zhang. 11C-Labeled Radiotracer for Noninvasive and Quantitative Assessment of the Thiocyanate Efflux System in the Brain. Bioconjugate chemistry. 2022. 33. 9. 1654-1662
Tatsuya Kikuchi, Masanao Ogawa, Toshimitsu Okamura, Antony D. Gee, Ming-Rong Zhang. Rapid 'on-column' preparation of hydrogen [C-11]cyanide from [C-11]methyl iodide via [C-11]formaldehyde. CHEMICAL SCIENCE. 2022. 13. 12. 3556-3562
Toshimitsu Okamura, Satoshi Tsukamoto, Kotaro Nagatsu, Maki Okada, Katsuyuki Minegishi, Takayuki Tatsumi, Aya Sugyo, Tatsuya Kikuchi, Hidekatsu Wakizaka, Hideki Ishii, et al. 6-[124I]Iodo-9-pentylpurine for Imaging the Activity of the Sodium Iodide Symporter in the Brain. Journal of medicinal chemistry. 2020. 63. 4. 1717-1723
Toshimitsu Okamura, Maki Okada, Tatsuya Kikuchi, Hidekatsu Wakizaka, Ming-Rong Zhang. Mechanisms of glutathione-conjugate efflux from the brain into blood: Involvement of multiple transporters in the course. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2020. 40. 1. 116-125
ｍore...
Patents (1)：
コリンエステラーゼ活性測定用試薬
Books (2)：
PET and SPECT of Neurobiological Systems
Springer 2020 ISBN:3030531759
Clinical Neuroscience Vol.36 (18年) 06月号
中外医学社 2018
Professional career (1)：
博士(薬学) (千葉大学)
Work history (1)：
2016/04 - 現在 National Institutes for Quantum and Radiological Science and Technology
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