Rchr
J-GLOBAL ID:200901003999992550
Update date: Feb. 23, 2024
Kojima Chojiro
コジマ チョウジロウ | Kojima Chojiro
Affiliation and department:
Job title:
Professor
Other affiliations (3):
Homepage URL (1):
http://nmrlab.ynu.ac.jp/
Research field (1):
Structural biochemistry
Research keywords (4):
Chemical Biology
, Structural Biology
, Biological Chemistry
, NMR
Research theme for competitive and other funds (35):
- 2020 - 2023 Protein structure analysis in human cell using advanced in-cell NMR techniques
- 2019 - 2023 植物NB-LRR受容体による免疫活性化と病原菌による宿主転写制御の分子基盤
- 2019 - 2021 Protein structure based drug design for regulation of flowering
- 2018 - 2021 Development of fully automated NMR data analysis assisted by AI
- 2014 - 2018 Site selective cellular analysis by solid-state NMR
- 2014 - 2018 TOR kinase complexes that sense and integrate major nutritional signals
- 2014 - 2018 In situ Protein NMR Structure Analysis
- 2015 - 2016 低分子化合物ライブラリーを用いたフッ素NMRスクリーニング
- 2014 - 2016 Protein NMR method developed for macromolecular complex
- 2012 - 2016 Structural probing of RNA molecules with in-cell NMR
- 2012 - 2015 Detection of structural change of DNA using disulfide bond formation and its application to elucidation of molecular recognition mechanisms
- 2012 - 2014 Analysis of the structural dynamics of the flagellar motor proteins using NMR
- 2012 - 2014 New NMR methods developed for structure determination of large proteins
- 2011 - 2014 NMR live imaging technology to monitor membrane protein structure
- 2012 - 2013 Molecular Mechanism of Florigen Function and Application of Florigen to Crop Improvement
- 2012 - 2012 In situ膜蛋白質間相互作用NMR検出技術
- 2010 - 2011 In situ膜タンパク質NMR検出技術
- 2008 - 2010 Structural bases of spliceosome indepemdent splicing
- 2007 - 2008 CHPによるNa+/H+交換輸送体NHE1の活性制御機構の解明
- 2006 - 2007 Structural basis of IRE1 mRNA splicing mechanism
- 2006 - 2007 Na+/H+交換輸送体複合体の構造と細胞膜・細胞骨格との相互作用
- 2006 - 2007 ガン細胞特異的な細胞内pH制御機構の構造的基盤
- 2005 - 2006 CHPによるNa十/H+交換輸送体NHE1活性化機構の解明
- 2004 - 2005 Gel-phaseNMR法の開発と膜蛋白質への応用
- 2002 - 2003 DNAの動的側面から見る遺伝子情報の制御機構
- 2002 - 2003 Proteome Analysis for Early Diagnosis of Prion Disease
- 植物免疫における受容体型細胞質キナーゼを介したMAPKカスケードの活性化機構
- Florigen complex structure and its chemical regulation
- In cell NMR structure determination
- 低分子化合物ライブラリーを用いたフッ素NMRスクリーニング
- 創薬等ライフサイエンス研究のための相関構造解析プラットフォームによる支援と高度化(創薬基盤NMR技術の開発)
- NMR分子置換法の開発
- データベースを利用したNMR創薬支援パイプラインの開発
- 病原体による宿主脂質ハイジャック機序の解明と創薬への応用(タンパク質-脂質間の物理的相互作用解析手法の改良・開発とLTPへの適用)
- Fully automated NMR structure determination system for larger protein
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Papers (243):
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Yuki Inada, Yuichiro Ono, Kyo Okazaki, Takuma Yamashita, Tomoyuki Kawaguchi, Shingo Kawano, Yoshihiro Kobashigawa, Shoko Shinya, Chojiro Kojima, Tsuyoshi Shuto, et al. Hydrogen bonds connecting the N-terminal region and the DE loop stabilize the monomeric structure of transthyretin. Journal of biochemistry. 2023. 174. 4. 355-370
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Jeffrey C Hoch, Kumaran Baskaran, Harrison Burr, John Chin, Hamid R Eghbalnia, Toshimichi Fujiwara, Michael R Gryk, Takeshi Iwata, Chojiro Kojima, Genji Kurisu, et al. Biological Magnetic Resonance Data Bank. Nucleic Acids Res. 2023. 51. D1. D368-D376
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Ken-ichiro Taoka, Ikumi Kawahara, Shoko Shinya, Ken-ichi Harada, Eiki Yamashita, Zenpei Shimatani, Kyoko Furuita, Tomoaki Muranaka, Tokitaka Oyama, Rie Terada, et al. Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening. Plant J. 2022. 112. 6. 1337-1349
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Takeshi Yamada, Kyoko Furuita, Shuhei Sakurabayashi, Makoto Nomura, Chojiro Kojima, Kazuhiko Nakatani. NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA. Nucleic Acids Research. 2022. 50. 17. 9621-9631
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Yoshiyuki Tanaka, Daichi Yamanaka, Saori Morioka, Taishi Yamaguchi, Masayuki Morikawa, Takashi S. Kodama, Vladimír Sychrovský, Chojiro Kojima, Yoshikazu Hattori. Physicochemical Characterization of the Catalytic Unit of Hammerhead Ribozyme and Its Relationship with the Catalytic Activity. Biophysica. 2022. 2. 3. 221-239
more...
MISC (143):
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藤井汐美, 児玉高志, 杉木俊彦, 花田賢太郎, 藤原敏道, 児嶋長次郎, 児嶋長次郎. Aggregation of the CERT START domain and its prevention. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
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榎本麻由, 安澤すあい, 小泉優香, 古板恭子, 田岡健一郎, 田岡健一郎, 西田敬二, 近藤昭彦, 児玉高志, 藤原敏道, et al. イネ花成ホルモン蛋白質複合体によるLLPS形成と花成制御機構. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
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板坂佑真, 小篭蒼, 古板恭子, 杉木俊彦, 若松馨, 内田紀之, 石田康博, 相田卓三, 藤原敏道, 児嶋長次郎, et al. Development of RDC measurement method for protein using titanium oxide nanosheets and non-detergent sulfobetaines. Abstracts. Annual Meeting of the NMR Society of Japan. 2022. 61st
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櫻林修平, 櫻林修平, 古板恭子, 山田剛史, 藤原敏道, 中谷和彦, 児嶋長次郎, 児嶋長次郎. DNA recognition mechanism of naphthyridine dimer, a CGG repeat-binding drug, analyzed by NMR. Abstracts. Annual Meeting of the NMR Society of Japan. 2022. 61st
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古板恭子, 児玉高志, 児玉高志, 児玉高志, 杉木俊彦, 赤木謙一, 物部容子, 榎園能章, 門田典子, 中村光咲, et al. In-cell NMR study using human cells: Analysis of protein three-dimensional structure and dynamics. Abstracts. Annual Meeting of the NMR Society of Japan. 2022. 61st
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Books (2):
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タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例 ~AlphaFold、In silico創薬、NMR、X線、クライオ電子顕微鏡~
技術情報協会 2023 ISBN:9784861049712
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創薬研究のための相互作用解析パーフェクト(実験医学別冊)
羊土社 2021 ISBN:9784758122566
Lectures and oral presentations (2):
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植物構造生物学研究と創薬
(植物科学シンポジウム2018)
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NMR tools developed for protein-drug and protein-protein interaction studies
(The 6th International Symposium on Drug Discovery and Design by NMR)
Education (3):
- 1992 - 1995 Osaka University Graduate School, Division of Natural Science Department of Inorganic and Physical Chemistry
- 1990 - 1992 Osaka University Graduate School, Division of Natural Science Department of Inorganic and Physical Chemistry
- 1986 - 1990 Osaka University Faculty of Science Department of Chemistry
Professional career (2):
- Master of Science (Osaka University)
- Doctor of Science (Osaka University)
Work history (16):
- 2018/04 - 現在 Yokohama National University Graduate school of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Professor
- 2016/04 - 現在 Osaka University Institute for Protein Research Professor
- 2016/04 - 現在 Yokohama National University Graduate School of Engineering Department of Materials Science and Engineering Professor
- 2016/04 - 現在 Yokohama National University College of Engineering Science Department of Chemistry, Chemical Engineering and Life Science Professor
- 2016/04 - 現在 Yokohama National University Faculty of Engineering Division of Materials Science and Chemical Engineering Professor
- 2016/04 - 現在 Osaka University Institute for Protein Research Visiting Professor
- 2016/04 - 現在 Yokohama National University Graduate School of Engineering Professor
- 2016/05 - 2023/03 RIKEN Quantitative Biology Center Senior Visiting Scientist
- 2010/02 - 2016/03 Osaka University Institute for Protein Research Associate Professor
- 2007/04 - 2010/02 Nara Institute of Science and Technology Graduate School of Biological Sciences Associate Professor
- 2001/04 - 2007/03 Nara Institute of Science and Technology Graduate School of Biological Sciences Associate Professor (as old post name)
- 2005/04 - 2006/03 Osaka University Institute for Protein Research Visiting Associate Professor
- 1998/10 - 2001/03 Tokyo Metropolitan University Faculty of Science CREST Fellow
- 1995/08 - 1998/09 UCSF Department of Pharmaceutical Chemistry Visiting Fellow
- 1994/04 - 1996/12 Osaka University Institute for Protein Research Special researcher of the Japan Society for the Promotion of Science
- 1994/04 - 1996/12 Osaka University Institute for Protein Research JSPS Fellow
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Committee career (3):
- 2015/06 - 2019/06 日本蛋白質科学会 役員(選管、渉外)
- 2017/04 - 2019/03 日本生物物理学会 代議員
- 2012/04 - 2018/03 日本核磁気共鳴学会 評議員
Association Membership(s) (1):
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