Research field (6)：
Tumor diagnostics and therapeutics
, Tumor diagnostics and therapeutics
, Medical systems
, Tumor diagnostics and therapeutics
, Nanomaterials
, Clinical pharmacy
Research keywords (7)：
Microbubble
, Liposome
, Nanotechnology
, Theranostics
, Cancer immunotheraoy
, Ultrasound
, Drug Delivery System
Research theme for competitive and other funds (25)：
2023 - 2026 Establishment of Ultrasound Control Technique of Microbubble-Encapsulated Vesicles and Its Medical Applications
2022 - 2025 新規メンケス病治療薬創製を目指した銅錯体の体内動態および薬効の検討
2022 - 2025 Photoreaction of thioamides and its application to medicinal chemistry
2020 - 2024 Development of the integrated therapeutic strategy aiming toward drug discovery and pharmacotherapy for treatment-resistant schizophrenia
2020 - 2024 Fablication of three-dimensional tube structure with multilayer by applying active cell control using microbubbles and acoustic radiation force
2020 - 2023 Development of novel cancer therapy based on promotion of tumor infiltrating lymphocyte by the immunomodulation with ultrasound technology
2020 - 2023 Elucidation of mechanical and biological effects of oscillating microbubbles on capillary endothelial cells and extravasation
2020 - 2023 in vivo遺伝子導入による軟骨再生医療への展開
2017 - 2021 Elucidation of mechanisms and expansion of application range of sonoporation by in situ observation of bubble-cell interaction
2017 - 2020 Development of novel strategy for pancreatic cancer with ultrasound sensitive nanomedicine
2017 - 2020 Development of cell delivery system attaching flexible ultrasound array on body surface
2016 - 2019 Development of bubble preparation for ultrasound theranostics
2016 - 2019 Development of antibody delivery system by ultrasound responsive nano bubble and breast cancer treatment strategy
2015 - 2018 Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system
2014 - 2017 Establishment of in vivo cell delivery technique using bubble aggregation under ultrasound exposure
2014 - 2016 Development of theranostics for cancer with tumor targeted bubbles and ultrasound
2011 - 2014 Ultrasound cancer therapy in next-generation with liposomal nanobubbles having both functions of diagnostics and therapeutics
2011 - 2013 Development of drug and gene delivery into brain with ultrasound technologies
2009 - 2010 The combination therapy of mild-hyperthermia with therapeutic ultrasound and dendritic cell-based immunotherapy
2008 - 2010 Development of in vivo sonoporation method using short-pulsed ultrasound with microbubbles adjacent to cells.
2004 - 2010 腫瘍組織へのリポソームを用いて薬物デリバリー
2004 - 2010 Drug Delivery to Tumor tissue using liposome
2007 - 2009 Development of siRNA delivery system by the combination of bubble liposomes and ultrasound
2007 - 2009 cancer gene therapy using non-invasive gene delivery with Bubble liposomes and ultrasound
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Papers (242)：
Ayako Noguchi, Shunya Watanabe, Kota Konishi, Narumi Ogawa, Yoshitaka Miyamoto, Daiki Omata, Ryo Suzuki, Kohji MASUDA. Experimental conditions for efficient retention of vascular endothelial cells on channel wall using lipid bubbles and acoustic interference. Japanese Journal of Applied Physics. 2024
Narumi Ogawa, Yoshiki Ito, Shunya Watanabe, Shinnosuke Araki, Naoya Yoshida, Kota Konishi, Ayako Noguchi, Yoshitaka Miyamoto, Daiki Omata, Ryo Suzuki, et al. Investigation of damage in vascular endothelial cells caused by existence of lipid bubbles under ultrasound irradiation to verify protective effect on cells. Japanese Journal of Applied Physics. 2024
Shohko Sekine, Sayaka Mayama, Nobuaki Nishijima, Takuo Kojima, Yoko Endo-Takahashi, Yuko Ishii, Hitomi Shiono, Saki Akiyama, Akane Sakurai, Sanae Sashida, et al. Development of a Gene and Nucleic Acid Delivery System for Skeletal Muscle Administration via Limb Perfusion Using Nanobubbles and Ultrasound. Pharmaceutics. 2023. 15. 6. 1665
Naoya Kajita, Yoshiki Ito, Shunya Watanabe, Yoshitaka Miyamoto, Daiki Omata, Kazuo Maruyama, Ryo Suzuki, Kohji Masuda. Viability variation of T-cells under ultrasound exposure according to adhesion condition with bubbles. Journal of Medical Ultrasonics. 2023
Yuno Suzuki, Lisa Munakata, Daiki Omata, Keiichi Koizumi, Ryo Suzuki. Feasibility study of novel nanoparticles derived from Glycyrrhizae radix as vaccine adjuvant for cancer immunotherapy. Immunotherapy. 2023. 14. 18. 1443-1455
Daiki Omata, Lisa Munakata, Kazuo Maruyama, Ryo Suzuki. Ultrasound and microbubble-mediated drug delivery and immunotherapy. JOURNAL OF MEDICAL ULTRASONICS. 2022
渡部舜也, 近嵐匠, 伊藤芳樹, 荒木信乃介, 宮本義孝, 小俣大樹, 鈴木亮, 鈴木亮, 丸山一雄, 丸山一雄, et al. Comparison of retention amount of bubble-surrounded cells on vessel wall between adhered and floating situations under ultrasound exposure. 超音波医学 Supplement. 2022. 49
伊藤芳樹, 齊藤達也, 渡部舜也, 吉田直也, 宮本義孝, 鈴木亮, 鈴木亮, 小俣大樹, 丸山一雄, 桝田晃司. Validation of damage on vascular endothelial cells under ultrasound exposureaccording to adhered density of bubbles. 超音波医学 Supplement. 2022. 49
