Rchr
J-GLOBAL ID:200901004687741351
Update date: Apr. 14, 2024
Inokuchi Jin'ichi
イノクチ ジンイチ | Inokuchi Jin'ichi
Affiliation and department:
Job title:
Professor
Other affiliations (1):
-
Tohoku Medical and Pharmaceutical University
Institute of Molecular Biomembrane and Glycobiology
Visiting Professorc
Homepage URL (2):
https://www.frc.sci.osaka-u.ac.jp/about-us/organization
,
https://www.frc.sci.osaka-u.ac.jp/en/
Research field (2):
Pharmacology
, Functional biochemistry
Research keywords (4):
chronic inflammation
, glycoimmunology
, glycosphingolipid
, マイクロドメイン
Research theme for competitive and other funds (26):
- 2022 - 2025 海洋動物レクチンを細胞内に取り込む分子機序とそれを利用した新規がん治療法の開発
- 2020 - 2024 New paradigm for the regulation of chronic inflammation by glycosphingolipids
- 2017 - 2020 腸管免疫機構と炎症性腸疾患の病因・病態におけるガングリオシドの機能解明
- 2017 - 2019 New paradigm for innate immune regulatory mechanism and chronic inflammation mediated by ganglioside molecular species
- 2016 - 2019 Elucidation of a novel inflammation amplification loop by ganglioside molecular species
- 2014 - 2016 聴覚におけるガングリオシドの機能解明
- 2011 - 2014 Emerging pathophysiological roles of ganglioside GM3
- 2009 - 2011 Involvement of insulin resistance-associated ganglioside GM3 in the pathogenesis of bronchial asthma.
- 2007 - 2008 Pharmacological studies in accelerating mechanism of Alzheimer's disease by diabetes mellitus with insulin resistance in rats
- 2006 - 2007 ガングリオシドGM3合成酵素遺伝子診断による非小細胞肺癌の抗癌剤感受性の予測
- 2004 - 2005 A research of regulation of glycosphingolipids gene expression and anticancer drug sensitivity in human oral cancer cell lines
- 2003 - 2004 癌および2型糖尿病の病態とスフィンゴ糖脂質マイクロドメイン
- 2003 - 2004 Involvement of ganglioside in lifestyle-related disease and cancer, and the development of new diagnostic method and therapeutic strategy
- 2000 - 2004 スフィンゴシン1-リン酸とその受容体の情報伝達機構と生理機能の解析
- 1999 - 2001 The protective effects of sphingolipid synthetic drug (L-PDMP) on apoptotic cell damage in cerebral infarction
- 1999 - 2001 Studies on neuronal functions by modulators of glycosphingolipid synthesis
- 2000 - 2000 ガングリオシド発現調節による大脳皮質シナプス機能および神経分化に関する研究
- 1999 - 2000 Biological functions of a lipid mediator, sphingosine 1-phosphate
- (]G0002[)型糖尿病におけるインシュリン抵抗性発症におけるガングリオシドの関与
- 癌・糖尿病におけるスフィンゴ糖脂質マイクロドメインの機能
- 糖脂質生合成促進物質を用いた神経疾患治療に対する基礎的検討。
- ガングリオシドの神経機能(特にシナプス機能と記憶形成過程)の研究
- Role of Ganglioside in Insulin Resistance of type 2 Diabetes
- Roles of Glycosphingolipid Microdomain in cancer and Type 2 Diabetes
- Application of stimulator of glycosphingolipid Biosynthesis for the treatment of neurological disorders
- Elucidation of functional roles of gangliosides in synaptic function and memory formation
Show all
Papers (215):
-
Go Anan, Takahiro Nitta, Hirotaka Kanoh, Makoto Sato, Jin-Ichi Inokuchi. Perioperative changes in ganglioside monosialodihexosylganglioside (GM3) molecular species for benign prostatic hyperplasia: a preliminary report. Translational andrology and urology. 2024. 13. 1. 104-108
-
Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Taiga Aoki, Jun-Ichi Furukawa, Akira Togayachi, Kiyoko Aoki-Kinoshita, Jin-Ichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, et al. Predicting the pathogenicity of missense variants based on protein instability to support diagnosis of patients with novel variants of ARSL. Molecular Genetics and Metabolism Reports. 2023. 37. 101016-101016
-
Kazuya Takeda, Tomonori Kaifu, Ryunosuke Michihata, Naotaka Kinugawa, Atushi Fujioka, Ayaka Tateno, Kaoru Toshima, Hirotaka Kanoh, Kei-Ichiro Inamori, Keiju Kamijo, et al. Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors. European journal of immunology. 2023. e2350452
-
Motohide Murate, Noriko Yokoyama, Nario Tomishige, Ludovic Richert, Nicolas Humbert, Brigitte Pollet, Asami Makino, Nozomu Kono, Laura Mauri, Junken Aoki, et al. Cell density-dependent membrane distribution of ganglioside GM3 in melanoma cells. Cellular and molecular life sciences : CMLS. 2023. 80. 6. 167-167
-
樺山 一哉, 黄 栩昊, 狩野 裕考, 井ノ口 仁一, 深瀬 浩一. スフィンゴミエリン分子種によるTLR4シグナルと細胞死の制御. 脂質生化学研究. 2023. 65. 207-209
more...
MISC (129):
-
狩野裕考, 新田昂大, 井ノ口仁一. GM3 ganglioside-mediated control of TLR4 signaling. 月刊メディカル・サイエンス・ダイジェスト. 2022. 48. 1
-
新田昂大, 狩野裕考, 稲森啓一郎, 鈴木明身, 井ノ口仁一. 1型と2型糖尿病性腎症における腎スフィンゴ糖脂質発現変化の比較. 日本生化学会大会(Web). 2021. 94th
-
大垣仁之, 樺山一哉, 樺山一哉, 内藤ひかり, 下山敦史, 下山敦史, 狩野裕孝, 井ノ口仁一, 深瀬浩一, 深瀬浩一. Functional Evaluation of TLR4 Ligand~Analyses by Reporter Assay and Imaging~. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
-
狩野裕考, 新田昂大, 井ノ口仁一. ガングリオシドGM3分子種による生活習慣病・慢性炎症性疾患等の新規診断・治療法の開発. 臨床病理. 2020. 68. 1
-
名取良浩, 若松秀章, 伊藤瑛將, 袰地陽太, 金野美里, 斎藤有香子, 井ノ口仁一, 吉村祐一. Synthesis of the long-chain fatty acid as analogue of GM3 ceramide. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
more...
Lectures and oral presentations (39):
-
GM3 ganglioside ln insulin resistance and inflammation
(International Endotoxin and Innate Immunity Society 2021)
-
Homeostatic and Pathogenic Roles of Ganglioside GM3
(WEBINAR SERIES ON SPHINGILOPID BIOLOGY -SphingoLeader Lecture- 2020)
-
Homeostatic and Pathogenic Roles of Ganglioside GM3 molecular species in TLR4 signaling
(12th International Symposium on Glycosyltransferases, Glyco-T 2020 2020)
-
Homeostatic and Pathogenic Roles of Ganglioside GM3 Molecular Species in TLR4 Signaling
(FEBS Special Meeting 2019 Sphingolipid Biology: Sphingolipids in Physiology and Pathology 2019)
-
New Paradigm for Chronic Inflammation Mediated by Glycosphingolipids.
(MicrobiotaMi2018 2018)
more...
Education (3):
- - 1979 Fukuoka University Division of Pharmaceutical Sciences
- - 1977 Fukuoka University Faculty of Pharmaceutical Sciences Department of Pharmaceutics
- - 1977 Fukuoka University Faculty of Pharmaceutical Science
Professional career (1):
Work history (9):
- 2023/04 - 現在 Tohoku Medical and Pharmaceutical University Institute of Molecular Biomembrane and Glycobiology Visiting Professorc
- 2022/10 - 現在 Osaka University Graduate School of Science Project Research Center for Fundamental Sciences Specially-appointed Professor
- 2019/04 - 2023/03 Tohoku Medical and Pharmaceutical University Institute of Molecular Biomembrabe and Glycobiology Specially-Appointed Professor
- 2021/04 - 2022/09 Osaka University Graduate School of Science,Forefront Research Center (FRC) Invited Professor
- 2016/04 - 2018/03 Tohoku Medical and Pharmaceutical University Division of Glycopathology, Insitute of Molevular Biomembrane and Glycobiology professor
- 2006/04 - 2016/03 Tohoku Pharmaceutical University Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology Professor
- 1998/04 - 2006/03 Associate Professor, Grad. Sch. of Pharm. Sci, Hokkaido Univ
- 1991/12 - 1998/03 生化学工業(株)東京研究所 主任研究員
- 1979 - 1991 Fukuoka University Faculty of Pharmaceutical Sciences
Show all
Committee career (8):
- 2018/04 - 現在 Japan Consortium For Glycobiology & Glycotechnology (JCGG) Standing secretary
- 2016/10 - 現在 Tohoku Glycoscience Forum President
- 2015/12 - 現在 The Japanese Society of Carbohydrate Research (JSCR) Secretary
- 2008/04 - 現在 Council member
- 1999/04 - 現在 Japan Consortium For Biology of Lipids Council member
- 2005/01 - 2023/08 Asian Society for Glycoscience and Glycotechnology (ACGG) Steering Committee Member
- 2006/04 - 2023/03 The Japanese Biochemical Society Council member
- 2018/04 - 2020/03 The Pharmaceutical Society of Japan member of brad of trustees
Show all
Association Membership(s) (5):
Japanese Society for Immunology
, 日本脂質生化学会
, 日本糖質学会
, 日本生化学会
, 日本薬学会
Return to Previous Page