2019 - 2022 Devising drug repositioning based on functional RNA integration analysis of small cell lung cancer.
2019 - 2022 Exploration of molecular pathways for lung cancer with interstitial pneumonia and development of new treatments based on understanding of functional RNA integration
2019 - 2022 Elucidation of therapeutic target molecular pathway by understanding tripli negative breast cancer and functional RNA integration
2019 - 2022 Elucidation of molecular pathogenesis of esophageal squamous cell carcinoma based on comprehensive functional RNA analysis
2019 - 2022 Drug repositioning strategy of head and neck squamous cell carcinoma after treatment failure based on microRNA analysis
2017 - 2019 Elucidation of metastasis promoting pathway involving ECM / integrin regulated by head and neck cancer suppressing microRNA
2016 - 2019 Development of nuclear acid medicine by using tumor suppressive microRNA conjugated with high molecular nano-micelle
2016 - 2019 Identification of activated molecular pathways involved in treatment-resistant head and neck squamous cell carcinoma
2016 - 2019 Development of the innovative treatment based on the search of microRNA blocking growth signals in urothelial carcinoma
2016 - 2019 Exploring molecular network of functional nucleic acid and developing therapeutic innovations in drug-resistant renal cell carcinoma
2016 - 2019 Elucidation of the microRNA-mediated RNA networks in castration resistant prostate cancer and development of innovative treatments
2016 - 2018 Investigation of the common RNA networks in lung cancer and idiopathic pulmonary fibrosis for the new strategy of the diseases.
2016 - 2018 Elucidation of extracellular matrix molecular pathway regulated by metastasis-suppressing microRNAs in prostate cancer.
2015 - 2018 Development of novel therapeutic strategies in head and neck squamous cell carcinoma based on microRNA-mediated cancer pathways
2015 - 2018 Elucidation of the extracellular matrix signal mechanism controled by tumor suppressor microRNAs in head and neck cancer
2014 - 2017 Investigation into the predictor of cetuximab effect based on microRNA in head and neck squamous cell carcinoma
2014 - 2017 Analysis of functional RNA networks and investigation of their target genes in castration-resistant prostate cancer (CRPC).
2014 - 2017 Study for elucidating tumor suppressive microRNA that has anti proliferation and prevent metastasis by using metastasis model mouse in bladder cancer
2014 - 2017 Development of novel nucleic acid treatment through nano-micelles delivering tumor suppressive microRNA in bladder cancer
2012 - 2017 Development of adjuvant therapy for head and neck cancer by activation of NKT cells via nasal mucosa
2014 - 2016 Investigation of hypoxia resistance in renal cell carcinoma based on functional RNA network analyses
2013 - 2016 Development of new therapeutic strategies of hypopharyngeal cancer based on the RNA network analysis
2013 - 2016 Order made therapy for bladder cancer by investigating functional RNAs associated molecular networks
2013 - 2016 Development of novel tumor markers for renal cell carcinoma by evaluating small nuclear acid in blood
2013 - 2016 Clarification of microRNA functional networks and development of novel tools for diagnosis and treatment of castration-resistant prostate cancer
2012 - 2015 Identification of tumor-suppressive microRNAs regulating metastatic pathways in HNSCC
2011 - 2013 Identification of tumor suppressive nucleic acid medicine in maxillary sinus squamous cell carcionma
2011 - 2013 Analysis of gene regulation networks controlled by microRNA in castration resistant prostate cancer
2010 - 2012 Anti-proliferative miRNA expression in squamous cell carcinoma of the lung: Pursue for the common therapeutic targets of the tobacco-related cancer
2009 - 2011 Identification of differentially expressed microRNAs in head and neck squamous cell carcinoma based on microRNA expression signature
2009 - 2010 Analysis of function and the target genes of micro-RNAs in prostate cancer
2008 - 2010 Role of Neuropeptide Signals Induced Metastasis of Hypopharyngeal Cancer
2008 - 2010 Developing new treatment modalities of urothelial carcinoma through regulating microRNA expression
2007 - 2008 Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer
2006 - 2007 The treatment strategy of bronchial dysplasia using a novel autofluorescence imaging bronchovideoscope system and microarray
2006 - 2007 Screening and validation of target molecules involved in mechanism of multi-modality therapy
2005 - 2006 Development of cancer immunotherapy using cancer-specific peptide based on genome analysis
2005 - 2006 The strategy based on gene expression profiling using microarray for tailor-made treatment in patients with lung cancer
2005 - 2006 The development of the novel genetherapy to enhance the radiation sensitivity.
2005 - 2006 Efficacy and natural course of therapeutic exercise for patients with knee osteoarthritis : Analysis by SNP
2004 - 2006 Identification of proteins associated with oral cancer by global proteomic approach.
2004 - 2005 Establishment of prediction system for the prognosis of patients with bladder cancer
2004 - 2005 Construction of in-house cDNA microarrays for identifying radiotherapeutic molecular markers in human aquamous cell carcinoma
2004 - 2005 Role of Endothelial progenitor Cell in the pathogenesis of COPD
2003 - 2004 唾液腺組織のcDNAライブラリー作成と唾液腺疾患用DNAチップの開発作製
2003 - 2004 Gene profiling in adenoid cystic carcinoma cells using in-house cDNA microaray
2003 - 2004 Gene expression profiling in primary lung cancer with oligonucleotide microarray.
2003 - 2004 ESTABLISHMENT OF AN INTRA-OPERATIVE TECHNIQUE FOE DETECTION OF MICROMETASTASES IN GASTRIC CANCER SURGERY USING LAMP GENE AMPLIFICATION.
2003 - 2004 Search for oral cancer specific genes and molecular cloning using in-house cDNA microaray
2001 - 2003 Development of the diagnostic method to evaluate the risks for carcinogenesis, micro-metastasis, and malignant grade of oral cancer using in-house cDNA microarray
2001 - 2003 Development of the method to select the most effective anti-cancer chemotherapy using in-house cDNA microarray
2001 - 2002 独自に開発したDNAチップを用いた発癌因子抵抗性評価および発癌予防法の開発
2001 - 2002 Identification of novel genes regulating fracture healing and their functional analyzes
2001 - 2001 白血病診断用独自作製DNAチップを用いた新規遺伝子の機能スクリーニング
2000 - 2001 Establishment of in-house cDNA microarray for analysis of pathogenicity of Toxoplasma gondii infection and developing methods of diagnosis and therapy for toxoplasmosis
Sasagu Kurozumi, Naohiko Seki, Eriko Narusawa, Chikako Honda, Shoko Tokuda, Yuko Nakazawa, Takehiko Yokobori, Ayaka Katayama, Nigel P Mongan, Emad A Rakha, et al. Identification of MicroRNAs Associated with Histological Grade in Early-Stage Invasive Breast Cancer. International journal of molecular sciences. 2023. 25. 1
Yoko Hagihara, Yuya Tomioka, Takayuki Suetsugu, Masahiro Shinmura, Shunsuke Misono, Yusuke Goto, Naoko Kikkawa, Mayuko Kato, Hiromasa Inoue, Keiko Mizuno, et al. Identification of Tumor-Suppressive miR-139-3p-Regulated Genes: TRIP13 as a Therapeutic Target in Lung Adenocarcinoma. Cancers. 2023. 15. 23
Reiko Mitsueda, Hiroko Toda, Yoshiaki Shinden, Kosuke Fukuda, Ryutaro Yasudome, Mayuko Kato, Naoko Kikkawa, Takao Ohtsuka, Akihiro Nakajo, Naohiko Seki. Oncogenic Targets Regulated by Tumor-Suppressive miR-30c-1-3p and miR-30c-2-3p: TRIP13 Facilitates Cancer Cell Aggressiveness in Breast Cancer. Cancers. 2023. 15. 16
