2016 - 2018 Elucidation of the molecular determinants of neonicotinoid toxicity
2013 - 2016 Elucidation of molecular mechanism of pyrethrin biosynthesis by a GDSL lipase and its application to creation of insect resistant plants
Papers (65)：
Noritada Matsuo, Yukimi Sugisaka, Shiori Aoyama, Makoto Ihara, Harue Shinoyama, Munetaka Hosokawa, Yoshinobu Kamakura, Daisuke Tanaka, Yoo Tanabe, Kazuhiko Matsuda. Creating Pyrethrin Mimetic Phosphonates as Chemical Genetics Tools Targeting the GDSL Esterase/Lipase TcGLIP to Investigate Pyrethrin Biosynthesis. Journal of Medicinal Chemistry. 2023. 66. 12. 7959-7968
Wataru Koizumi, Shuya Otsubo, Shogo Furutani, Kunihiro Niki, Koichi Takayama, Shota Fujimura, Takanobu Maekawa, Ryosuke Koyari, Makoto Ihara, Kenji Kai, et al. Determinants of subtype-selectivity of the anthelmintic paraherquamide A on Caenorhabditis elegans nicotinic acetylcholine receptors. Molecular pharmacology. 2023
Yuma Komori, Koichi Takayama, Naoki Okamoto, Masaki Kamiya, Wataru Koizumi, Makoto Ihara, Daitaro Misawa, Kotaro Kamiya, Yuto Yoshinari, Kazuki Seike, et al. Functional impact of subunit composition and compensation on Drosophila melanogaster nicotinic receptors-targets of neonicotinoids. PLoS genetics. 2023. 19. 2. e1010522
Koichi Takayama, Ryo Ito, Haruki Yamamoto, Shuya Otsubo, Rei Matsumoto, Hisanori Ojima, Yuma Komori, Kazuhiko Matsuda, Makoto Ihara. Effects of cofactors RIC-3, TMX3 and UNC-50, together with distinct subunit ratios on the agonist actions of imidacloprid on Drosophila melanogaster Dα1/Dβ1 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Pesticide Biochemistry and Physiology. 2022. 187. 105177-105177
Yukimi Sugisaka, Shiori Aoyama, Konoka Kumagai, Makoto Ihara, Kazuhiko Matsuda. TcGLIP GDSL Lipase Substrate Specificity Co-determines the Pyrethrin Composition in Tanacetum cinerariifolium. Journal of agricultural and food chemistry. 2022
S. Furutani, M. Ihara, Y. Nishino, M. Akamatsu, A. K. Jones, D. B. Sattelle, K. Matsuda. Exon 3 Splicing and Mutagenesis Identify Residues Influencing Cell Surface Density of Heterologously Expressed Silkworm (Bombyx mori) Glutamate-Gated Chloride Channels (vol 86, pg 686, 2014). MOLECULAR PHARMACOLOGY. 2015. 87. 1. 141-141
Yuri Nakatani, Shogo Furutani, Makoto Ihara, Kazuhiko Matsuda. Modulation by chloride-channel-targeting pesticides of proton-sensitive chloride channels expressed in the silkworm Bombyx mori. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2014. 248
Actions of clothianidin and related neonicotinoids on recombinant and native nicotinic acetylcholine receptors.
(XXII International Congress of Entomology, Brisbane, Australia 2004)
Structure activity relationship of clothianinidin and its related compounds
(The third Pan-Pacific Conference on Pesticide Science, Hawaii, USA. 2003)
Variations in agonist and antagonist profiles for neonicotinoids on recombinant nicotinic acetylcholine receptors expressed in Xenopus oocytes
(10th IUPAC International Congress on the Chemistry of Crop Protection, Basel, Switzerland. 2002)
Actions of clothianidin and related compounds on recombinant nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes
(Neurotox 2003, Nottingham, UK.)
Education (1)：
- 2005 Kindai University Graduate School of Agriculture Major in Advanced life Science
Professional career (1)：
PhD (Kinki University)
Work history (6)：
2018/04 - 現在 Kindai University Fuculty of agriculture Associate professor
2013/04 - 2018/03 Kinki University Faculty of Agriculture Lecturer
2012/12 - 2018/03 RIKEN SPring-8 Center Visiting Scientist
2012/12 - 2013/03 Okayama University, Graduate school of medicine, dentistry and pharmaceutical sciences Assistant Professor
2006/10 - 2012/11 RIKEN
2005/04 - 2006/09 近畿大学 研究員
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Awards (4)：
2018/03 - 日本農芸化学会 農芸化学奨励賞
2008 - 日本農学進歩賞
2007 - 望月喜多司記念賞 奨励賞
2007 - 日本農薬学会 奨励賞
Association Membership(s) (2)：
JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
, PESTICIDE SCIENCE SOCIETY OF JAPAN
