Rchr
J-GLOBAL ID:200901005042175803
Update date: Mar. 07, 2024
Takashima Seiji
タカシマ セイジ | Takashima Seiji
Affiliation and department:
Job title:
Professor
Other affiliations (6):
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Osaka University
Graduate School of Frontier Biosciences Department of Frontier Biosciences
Professor
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Osaka University
Faculty of Medicine, Medical School
Others
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Osaka University
Graduate School of Frontier Biosciences, Department of Frontier Biosciences, Graduate School of Frontier Biosciences Department of Frontier Biosciences
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Osaka University
Faculty of Medicine, Medical School, Faculty of Medicine, Medical School
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Osaka University
Graduate School of Frontier Biosciences, Department of Frontier Biosciences, Graduate School of Frontier Biosciences Department of Frontier Biosciences
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Osaka University
Faculty of Medicine, Medical School, Faculty of Medicine, Medical School
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Homepage URL (1):
http://medbio.sakura.ne.jp/
Research field (2):
Cardiology
, Medical biochemistry
Research keywords (6):
創薬
, 生化学
, 循環器内科
, Pathophysiology
, Biochemistry
, Cardiovascular Medicine
Research theme for competitive and other funds (26):
- 2022 - 2025 全ゲノム解析基盤による機能・情報統合解析と新規心筋症遺伝子の同定および機序解明
- 2021 - 2024 酸化的リン酸化酵素群の分子構造機構の解明と創薬展開に向けた基盤研究
- 2018 - 2021 Development and clinical application of low molecular chemicals that modulate myosin light chain kinase for the treatment of heart failure with preserved ejection fraction
- 2016 - 2019 Therapeutic Application of Genome Editing for Advanced Heart Failure
- 2016 - 2018 Deciphering the factors associated with selective demethylation of tissue-specific gene promoter
- 2015 - 2018 Elucidation of the regulatory mechanism of natriuretic hormone expression for oral heart failure drug development
- 2015 - 2016 エネルギー代謝と細胞運動の相関解析による新しい循環器病治療薬の開発
- 2014 - 2016 Identification and purification of cardiac fibroblast-specific FGF23 receptor
- 2014 - 2015 Development of simple and noninvasive method to assess the severity of heart failure
- 2012 - 2015 Cardiac Myosin Light Chain Kinase Mutation as a Cause of Cardiomyopathies
- 2011 - 2015 Establishment of a basis to study vertebrate phoneme based on transposon-mediated genetic methods
- 2012 - 2014 Development of novel drugs for heart failure treatment based on modulating kinase activity of cardiac-MLCK
- 2010 - 2012 The elucidation of mechanisms for myseterin and its susceptibility variant and development of prevention program for moyamoya disease.
- 2010 - 2012 Identification and functional analysis of the factors that interact with cardiac protective factor HB-EGF
- 2007 - 2012 非分裂細胞である心筋細胞の代謝維持機構の解明を行うことによる循環器疾患の新規治療戦略の構築
- 2009 - 2011 Role of splicing variants in heart failure
- 2008 - 2010 Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease
- 2005 - 2010 高分離能カラムの初期利用による生理活性物質検索法の開発
- 2008 - 2008 新しい概念(エピジェネティクス)を応用した難治性心不全発症分子メカニズムの解明
- 2007 - 2008 Pathophysiological Role of ER-Ubiquitin/Proteasome System in Cardiovascular Remodeling
- 2007 - 2008 Translational research of adenosine aiming for diagnosis and treatment of heart failure
- 2005 - 2006 The role of ER stress and ubiquitin-proteasome system in the development of heart failrue
- 2005 - 2006 New therapeutic approach for heart failure using HB-EGF mediated signal transduction
- 2004 - 2005 Experimental and clinical evaluation of cardioprotective effects by adenosine and nitric oxide
- 2000 - 2001 Acquirement of the Ischemic Cardioprotection and ecto-5'-nucleotidase : Investigation of the Receptor Activation and Subsequent Signal Transduction
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Papers (221):
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Chisato Okamoto, Osamu Tsukamoto, Takuya Hasegawa, Ken Matsuoka, Makoto Amaki, Hideaki Kanzaki, Chisato Izumi, Seiji Takashima, Shin Ito, Masafumi Kitakaze. Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals. JACC: Asia. 2024
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Osamu Tsukamoto, Seiji Takashima. Response by Tsukamoto and Takashima to Letter Regarding Article, "Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Super-Relaxed Myosin". Circulation. 2023. 148. 25. 2074-2075
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Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, et al. Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload. iScience. 2023. 107146-107146
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Tatsuro Hitsumoto, Osamu Tsukamoto, Ken Matsuoka, Junjun Li, Li Liu, Yuki Kuramoto, Shuichiro Higo, Shou Ogawa, Noboru Fujino, Shohei Yoshida, et al. Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin. Circulation. 2023. 147. 25. 1902-1918
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Satoshi Kameda, Shuichiro Higo, Mikio Shiba, Takumi Kondo, Junjun Li, Li Liu, Tomoka Tabata, Hiroyuki Inoue, Shota Okuno, Shou Ogawa, et al. Modeling Reduced Contractility and Stiffness Using iPSC-Derived Cardiomyocytes Generated From Female Becker Muscular Dystrophy Carrier. JACC: Basic to Translational Science. 2023
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MISC (335):
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高橋 佑典, 齋藤 茂芳, 木岡 秀隆, 荒木 力太, 高島 成二, 坂田 泰史, 吉岡 芳親. 11.7T-MRI装置を用いたマウス下肢骨格筋CrCESTイメージングの確立. 日本放射線技術学会雑誌. 2019. 75. 9. 1050-1050
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FEBRIAN Jeremia, 喜多絢海, 谷口健悟, 和島壮一, 斎藤里緒, 高島成二, 高島成二, 土井健史, 樋野展正. DNA脱メチル化関連酵素TET1の活性調節機構の解析. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
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朝野仁裕, 木岡秀隆, 宮下洋平, 多久和綾子, 高島成二, 坂田泰史. 希少循環器疾患におけるゲノム解析による遺伝子診断. 日本心不全学会学術集会プログラム・抄録集. 2018. 22nd
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多久和 綾子, 川上 知紗, 木岡 秀隆, 山田 憲明, 宮下 洋平, 四宮 春輝, 伯井 秀行, 世良 英子, 大谷 朋仁, 山口 修, et al. 心筋症のエクソーム解析による原因変異探索. 生命科学系学会合同年次大会. 2017. 2017年度. [3P-0731]
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林 研至, 野村 章洋, 朝野 仁裕, 藤野 陽, 坂田 憲治, 今野 哲雄, 多田 隼人, 津田 豊暢, 寺本 了太, 永田 庸二, et al. 心臓突然死の遺伝的背景 早発性心臓伝導障害患者のエクソームシーケンシング(Exome Sequencing for Patients with Early-onset Cardiac Conduction Diseases). 日本循環器学会学術集会抄録集. 2017. 81回. SY09-5
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Works (5):
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臓器特性を利用した心血管疾患治療標的の探索と臨床応用
2011 -
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臓器特性を利用した心血管疾患治療標的の探索と臨床応用
2010 -
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心筋細胞の非分裂性を規定する因子の同定・機能解析と治療への応用
2010 -
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重症特発性心筋症患者の生体資料の収集および新規予後規定因子の検索・解析
2009 -
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心筋細胞の非分裂性を規定する因子の同定・機能解析と治療への応用に向けた基盤研究
2009 -
Professional career (1):
Work history (10):
- 2013/07 - 現在 Osaka Univ. Graduate School of Medicine, Frontier Biosciences Professor
- 2008/04 - 2013/06 Osaka Univ. Post Graduate School of Medicine Associate Professor
- 2004/04 - 2008/03 Osaka Univ. Health Center Assistant Professor
- 2003/12 - 2004/03 Osaka Univ. Health and Physical Dept. Assistant Professor
- 2001/12 - 2003/12 Osaka Univ. Graduate Shcool of Medicine Department of Cardiovascular Medicine Lecturer
- 1997/09 - 1997/11 Osaka Univ. Hospital Department of Cardiovascular Medicine Clinical Fellow
- 1993/04 - 1997/08 Harvard Univ. Medical Department Research Fellow
- 1989/04 - 1993/03 Osaka Univ. Post Graduate School of Medicine Post Graduate Student
- 1988/04 - 1989/03 Osaka Univ. Hospital Resident
- 1982/04 - 1988/03 Osaka Univ. Medical School Student
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Awards (1):
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