Rchr
J-GLOBAL ID：200901005100638096   Update date: Apr. 06, 2024

Nishiyama Makoto

ニシヤマ マコト | Nishiyama Makoto
Affiliation and department：
The University of Tokyo Graduate School of Agricultural and Life Sciences, Agro-Biotechnology Research Center, Laboratory of Cell Biotechnology

About The University of Tokyo Graduate School of Agricultural and Life Sciences, Agro-Biotechnology Research Center, Laboratory of Cell Biotechnology


Job title： Professor
Homepage URL  (2)： http://park.itc.u-tokyo.ac.jp/cbt/ ,  http://park.itc.u-tokyo.ac.jp/cbt/en/
Research field  (2)： Applied biochemistry ,  Applied microbiology
Research keywords  (2)： 応用微生物学・応用生物化学 ,  Applied Microbiology and Applied Biochemistry
Research theme for competitive and other funds  (29)：
  • 2022 - 2025 Studies on mining of novel enzymes functioning in secondary metabolite biosynthesis in Streptomyces and their molecular mechanism.
  • 2010 - 2020 Studies on enzymes creating natural product diversity
  • 2017 - 2018 Elucidation of structures and functions of metabolic enzymes of lysine and related compounds and their molecular evolution
  • 2017 - アミノ基キャリアタンパク質を介する生合成機構の解明と二次代謝産物構造多様性の拡張
  • 2014 - 2016 Metabolic regulation via protein acylation in Thermus thermophilus
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Papers (240)：
  • Genki Hibi, Taro Shiraishi, Tatsuki Umemura, Kenji Nemoto, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama. Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin. Nature Communications. 2023. 14. 1
  • Ryuhei Nagata, Makoto Nishiyama, Tomohisa Kuzuyama. Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase. Biochemistry. 2023
  • Toshihiko Katoh, Chihaya Yamada, Michael D Wallace, Ayako Yoshida, Aina Gotoh, Moe Arai, Takako Maeshibu, Toma Kashima, Arno Hagenbeek, Miriam N Ojima, et al. A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem. Nature chemical biology. 2023
  • Sumire Kurosawa, Hironori Okamura, Ayako Yoshida, Takeo Tomita, Yusuke Sone, Fumihito Hasebe, Tetsuro Shinada, Hirosato Takikawa, Saori Kosono, Makoto Nishiyama. Mechanisms of Sugar Aminotransferase-like Enzymes to Synthesize Stereoisomers of Non-proteinogenic Amino Acids in Natural Product Biosynthesis. ACS Chemical Biology. 2023
  • Yutaro Morita, Ayako Yoshida, Siyan Ye, Takeo Tomita, Minoru Yoshida, Saori Kosono, Makoto Nishiyama. Protein-protein interaction-mediated regulation of lysine biosynthesis of <i>Thermus thermophilus</i> through the function-unknown protein LysV. The Journal of General and Applied Microbiology. 2023
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MISC (51)：
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Books (4)：
  • Design of hydrophobic core of ┣DBE. coli(/)-┫DB malate dehydrogenase based on the side-chain packing
    Pacific symposium on biocomputing '97 1997
  • Site-directed mutagenesis revealed role of subsite residues of ┣DBMucor(/)-┫DB ┣DBpusillus(/)-┫DB popsin in catahytic function
    Asportic Proteinases: Structure, Function, Biology, and Biomedical Implications.(K. Takahashi ed.) Plenum Press, N.Y. 1995
  • Tyrosine 75 on the flap contributes to enhance catalytic efficiency of a fungal aspartic proteinase, ┣DBMucor(/)-┫DB ┣DBpusillus(/)-┫DB pepsin
    Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications (K.Takahashi ed.))Plenum-Press N.Y. 1995
  • A yeast expression system and site-directed mutagenesis of a fungal aspartic proreinage, ┣DBMucor(/)-┫DB rennin
    Structure and Functon of the Aspartic Proteinases(B. M. Dunn, ed. )Plenum Press, New York 1991
Lectures and oral presentations  (13)：
  • シクロラバンデュリル二リン酸合成酵素の結晶構造解析
    (日本農芸化学会大会講演要旨集(Web) 2017)
  • シクロラバンデュリル2リン酸合成酵素の結晶構造解析
    (イソプレノイド研究会例会講演要旨集 2016)
  • 放線菌由来ジテルペン環化酵素CotB2が触媒する精巧な環化反応機構の解明
    (日本農芸化学会大会講演要旨集(Web) 2016)
  • Corynebacterium glutamicum由来ホスホエノールピルビン酸カルボキシラーゼ(PEPC)のアセチル化制御はグルタミン酸生産に重要である
    (日本農芸化学会大会講演要旨集(Web) 2016)
  • 放線菌由来ジテルペン環化酵素CotB2の特異な環化反応機構の解明
    (イソプレノイド研究会例会講演要旨集 2015)
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Works (4)：
  • アスパラギン的プロテアーゼの構造と機能
    1994 - 2000
  • 耐熱性酵素の蛋白工学的研究
    1994 - 2000
  • Structure and function of aspaitic proteineses
    1994 - 2000
  • Protein engineering of thermostable enzymes
    1994 - 2000
Education (3)：
  • - 1988 The University of Tokyo
  • - 1986 The University of Tokyo Graduate School, Division of Agricultural Science
  • - 1984 The University of Tokyo
Professional career (1)：
  • (BLANK)
Work history (6)：
  • 2003 - 現在 The University of Tokyo
  • 1994 - 2003 The University of Tokyo
  • 1988 - 1994 The University of Tokyo
  • Professor
  • Associate Professor
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Awards (1)：
  • 1993 - 農芸化学奨励賞(社団法人 日本農芸化学会)
Association Membership(s) (9)：
アメリカ微生物学会 ,  アメリカ生化学分子生物学会 ,  日本ゲノム微生物学会 ,  SOCIETY FOR ACTINOMYCETES JAPAN ,  日本ビタミン学会 ,  日本生化学会 ,  日本蛋白質科学会 ,  日本分子生物学会 ,  日本農芸化学会
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