Hisamoto Naoki

Hisamoto Naoki | Hisamoto Naoki

Affiliation and department：
Job title： Professor

Research field (1)： Molecular biology

Research keywords (2)： axon regeneration , Signal Transduction

Research theme for competitive and other funds (28)：

2015 - 2017 遠位切断軸索からのダイイングコード

2014 - 2017 Regulation of axon regeneration in C. elegans

2014 - 2016 Global identification of factors acting with Parkinson disease/Alzheimer disease genes.

2012 - 2016 Mechanism of signal transduction regulating axon regeneration

2013 - 2015 アナンダミドによる軸索再生抑制機構の解析

2011 - 2013 酸化ストレスセンサーによるMAPKカスケード活性化機構の解明

2011 - 2013 Analyses of factors acting with Parkinson's disease gene LRRK2 using nematode as a model organism

2009 - 2011 Spatio-temporal regulation of cellular trafficking and signal transduction

2009 - 2010 MAPキナーゼカスケードを活性化する酸化ストレスセンサーの網羅的同定

2008 - 2010 Genome-wide analysis of C.elegans JNK cascade

2002 - 2007 線虫C. elegansをモデル動物としたストレス応答シグナル伝達経路の解析

2006 - 2007 Analysis of LRK-1 kinase which regulates polarized sorting in neurons

2002 - 2006 Analysis of stress-activated signal transduction pathway by using nematode as a model animal.

2004 - 2005 神経細胞の極性輸送を制御するキナーゼLRK-1の解析

2002 - 2003 線虫C.elegansをモデル動物としたp38MAPKカスケードの解析

2001 - 2002 線虫C. elegansをモデル動物としたシナプス小胞局在制御機構の解析

2001 - 2002 線虫C・elegansをモデル動物としたシナプス局在制御機礎の解析

2000 - 2001 線虫C.elegansをモデル動物としたp38 MAPKカスケードの解析

2000 - 2001 Functional analysis of phospholipase D (PLD) superfamily in Caenorhabditis elegans

2000 - 2001 線虫C.elegansをモデル動物としたp38MAPKカスケードの解析

1998 - 1998 線虫C.elegansの神経回路形成に関与するMAPキナーゼ経路の解析

1997 - 1998 線虫C.elegansの神経特異的な新規MAPキナーゼカスケードの解析

1997 - 1997 線虫C.elegansの神経特異的な新規MAPキナーゼカスケードの解析

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Papers (82)：

Hiroshi Hanafusa, Keitaro Fujita, Misa Kamio, Shiori Iida, Yasushi Tamura, Naoki Hisamoto, Kunihiro Matsumoto. LRRK1 functions as a scaffold for PTP1B-mediated EGFR sorting into ILVs at the ER-endosome contact site. Journal of Cell Science. 2023. 136. 6
Yoshiki Sakai, Hiroshi Hanafusa, Naoki Hisamoto, Kunihiro Matsumoto. Histidine dephosphorylation of the Gβ protein GPB-1 promotes axon regeneration in C. elegans. EMBO reports. 2022. 23. 12. e55076
Keitaro Fujita, Shin Kedashiro, Takuya Yagi, Naoki Hisamoto, Kunihiro Matsumoto, Hiroshi Hanafusa. The ULK complex-LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation. Journal of cell science. 2022. 135. 23
Hiroshi Hanafusa, Shin Kedashiro, Mako Gotoh, Ko-Hei Saitoh, Hironori Inaba, Tomoki Nishioka, Kozo Kaibuchi, Masaki Inagaki, Naoki Hisamoto, Kunihiro Matsumoto. LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport. Journal of cell science. 2022. 135. 21
Tatsuhiro Shimizu, Kayoko Sugiura, Yoshiki Sakai, Abdul R Dar, Rebecca A Butcher, Kunihiro Matsumoto, Naoki Hisamoto. Chemical signaling regulates axon regeneration via the GPCR-Gqα pathway in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021

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MISC (198)：

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Books (1)：

Lectures and oral presentations (2)：

Professional career (2)：

Work history (3)：

2017/04/01 - 現在 Nagoya University Graduate School of Science Division of Biological Science Cell Regulation Professor
2007/04/01 - 2017/03/31 Nagoya University Graduate School of Science Division of Biological Science Associate professor
2004/10/01 - 2007/03/31 Nagoya University Graduate School of Science Division of Biological Science Assistant Professor

Association Membership(s) (3)：

Society of Neuroscience , Japan Neuroscience Society , The Molecular Biology Society of Japan

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