HIRASAKI Masataka

ヒラサキマサタカ | HIRASAKI Masataka

Affiliation and department：
Job title： Lecturer

Research field (4)： Tumor diagnostics and therapeutics , Genomics , Molecular biology , Medical biochemistry

Research keywords (6)：ゲノム医療・診断 , ES細胞の未分化性の維持再生医療 , バイオマーカー , 再生医療 , 腫瘍 , ES細胞の未分化性の維持

Research theme for competitive and other funds (16)：

2023 - 2027 低容量植物ステロール摂取による動脈硬化の抑制機序の解明
2021 - 2024 Mbd3によるPrimed型多能性幹細胞の維持と分化の方向性の決定機構の解明
2022 - 2023 Autophagy関連遺伝子の SNV(single nucleotide variant)を基に食道癌の術前補助化学療法の治療選択を可能とする
2020 - 2022 Epi幹細胞の維持と分化の方向性の決定におけるMbd3の機能
2021 - 2022 Mbd3によるエピブラスト幹細胞の幹細胞性維持と分化の方向性の決定機構の解明

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Papers (34)：

Takehiro Nogi, Kousuke Uranishi, Ayumu Suzuki, Masataka Hirasaki, Tina Nakamura, Tomiei Kazama, Hiroshi Nagasaka, Akihiko Okuda, Tsutomu Mieda. Similarity and dissimilarity in alterations of the gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane. PloS one. 2024. 19. 3. e0298264
Yoshiaki Mihara, Masataka Hirasaki, Yosuke Horita, Takashi Fujino, Hisayo Fukushima, Yasuo Kamakura, Kousuke Uranishi, Yasumitsu Hirano, Shomei Ryozawa, Masanori Yasuda, et al. PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study. BMC gastroenterology. 2023. 23. 1. 339-339
Yasuhiro Takenaka, Masataka Hirasaki, Ikuo Inoue, Masaaki Ikeda, Hisayuki Ohata, Yoshihiko Kakinuma. Transcriptome analyses of mouse cardiac myocytes and non-cardiomyocytes: postmitotic vs. proliferative cells. 2023
Yasuhiro Takenaka, Ikuo Inoue, Masataka Hirasaki, Masaaki Ikeda, Yoshihiko Kakinuma. Temporal inhibition of the electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts. The FEBS journal. 2023. 290. 15. 3843-3857
Hitoshi Inoue, Masataka Hirasaki, Yasunao Kogashiwa, Yutaka Nakachi, Kiyomi Kuba, Yasuhiro Ebihara, Mitsuhiko Nakahira, Masanori Yasuda, Akihiko Okuda, Masashi Sugasawa. Identification of novel oncogenes in oral cancer among elderly nonsmokers. Clinical and experimental dental research. 2023. (in press)

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Patents (2)：

Lectures and oral presentations (52)：

マウス心筋細胞および非心筋細胞のトランスクリプトーム解析:個体老化における増殖停止細胞と増殖性細胞の比較
(第100回日本生理学会 2023)
細胞老化に伴って蓄積する老化関連凝集体の機能解析
(第45回分子生物学会年会 2022)
Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) arising from long-segment Barrett esophagus
(2022)
PTEN-induced kinase 1 gene single nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer
(2022)
Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) arising from long-segment Barrettʼs esophagus showing exceptionally aggressive clinical behavior
(第26回日本臨床内分泌病理学会学術集会 2022)

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Education (3)：

2002 - 2007 Osaka University Graduate School of Engineering Department of Biotechnology,
2000 - 2002 Ehime University Graduate School of Agriculture Department of Biological Resources
1996 - 2000 Fukuyama University Faculty of Engineering

Professional career (1)：

Work history (7)：

2020/04 - 現在埼玉医科大学医学部ゲノム基礎医学講師
2020/04 - 現在 Saitama Medical University International Medical Center Department of Clinical Cancer Genomics
2012/04 - 2020/03 埼玉医科大学ゲノム医学研究センターゲノム医学研究センター助教
2012/04 - 2020/03 Saitama Medical University Research Center for Genomic Medicine Division of Developmental Biology
2008/04 - 2012/03 Saitama Medical University Faculty of Medicine Molecular Biology

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Awards (8)：

2020/11 - 武田科学振興財団武田科学振興財団「医学系研究奨励」 2020年度 Epi幹細胞の維持と分化の方向性の決定におけるMbd3の機能
2019/12 - 埼玉医科大学学内グラント研究費 Mbd3によるエピブラスト幹細胞の幹細胞性維持と分化の方向性の決定機構の解明
2019/09 - 第17回 RCGMフロンティアシンポジウム第17回 RCGMフロンティアシンポジウム/最優秀ポスター賞
2016/11 - The 14th RCGM International Symposium The 14th RCGM International Symposium of Academic Frontier: The Best Poster Award Mbd3 variant lacking methyl-CpG binding domain exerts equivalent function to canonical Mbd3 for preserving differentiation potential of ESCs
2015/12 - 埼玉医科大学学内グラント研究費「Myc-Nanog複合体によるMax欠損ES細胞の多能性維持とアポトーシス抑制」

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Association Membership(s) (6)：

日本遺伝子診療学会 , 日本遺伝子診療学 , 日本癌学会 , 日本癌学会 , International Society for Stem Cell Research ( ISSCR) , The Molecular Biology Society of Japan

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