Kusakabe Takahiro

クサカベタカヒロ | Kusakabe Takahiro

Affiliation and department：
Job title： Associate Professor

Research field (1)： Conservation science (plants)

Research keywords (10)： insect factory , gene network model , chromosome , バキュロウイルス , 昆虫 , カイコ , クロマチン , 相同組換え , DNA修復 , DNA repair recombination silkworm insect chromatin baculovirus

Research theme for competitive and other funds (28)：

2021 - 2024 Generation of silkworm lacking silk gland suitable for insect factories
2019 - 2022 The inhibitory mechanism of amyloid fibrosis by peptides from hen egg proteins and prevention effects against diseases.
2014 - 2018 Establishment of research foundation on "objective pain assessment" using animal models suffering from neuropathic pain
2014 - 2018 Molecular basis of formation and regulation of insect holocentric chromosome
2015 - 2017 Fundamental Study on Preparations for Therapeutic Antibodies with Less Productions of Anti-Drug Antibodies

2015 - 2017 Redox-responsive hydrogels as potent matrices for fabrication of cell-based biomaterials

2014 - 2016 カイコ細胞におけるMAPK情報伝達経路の遺伝子ネットワーク解析

2014 - 2016 Expression and storage of genetic information in insect cells

2013 - 2016 昆虫における効率的な遺伝子ノックインシステムの構築

2012 - 2015 カイコ分散型染色体におけるクロマチン動態のエピジェネティック制御

2010 - 2014 Epigenetic control of the genome functions of transgenic insect

2010 - 2014 A systems biology approach for improving baculovector system

2011 - 2013 Analysis of dsRNA mechanism of response in insect cell

2009 - 2010 昆虫分散型動原体染色体の謎

2007 - 2009 Studies on physiological functions of ovalbumin and occurrence of neural tube defects due to deprivation of ovalbumin in chick embryo.

2005 - 2007 Molecular Evolutional, Geographical, Population Genetical analyses of Wild SilkMoth including Bombyx mandarina distribute in East Asian region

2005 - 2007 Molecular mechanism of gene targeting in insect cells and its applications

2005 - 2006 温泉ユスリカ由来耐熱タンパク質の解析

2002 - 2004 昆虫細胞におけるDNA修復と減数分裂期相同組換え

2001 - 2004 DEVELOPMENT OF NEW SYSTEM FOR EFFICIENCY UTILIZATION AND PREZERVATION ON THE GENETIC RESOURCES IN THE SILKWORM BOMBYX MORI.

2002 - 2003 カイコ突然変異体利用による高感度遺伝毒性検定系の開発

2002 - 2003 Sequence comparison of MLEs of some lepidopteran insects inhabiting in east Asia isolated by PCR method using the inverted terminal repeat of Cecropia MLE and the analysis of transposase activity of MLE isolated from Attacus atlas of Yonaguni island by the same method.

1998 - 2000 Studies on the characteristic of the egg-traits mutation genes in Bombyx mori

1999 - 1999 家蚕の5齢致死突然変異利用による変態制御機構の解析

1996 - 1999 DIFFERENTIAL EXPRESSION MECHANISMS OF HOUSEKEEPING AND LUXURY GENES DURING EMBRYONIC AND POST-EMBRYONIC DEVELOPMENT

1994 - 1994 アルドラーゼをモデル系とするアイソザイムの組織特異的機能獲得の分子機構の研究

DNA組み換えタンパク質に関する研究

Study on recombination protein

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Papers (182)：

Akira Tsukamoto, Lee Jae Man, Kosuke Oyama, Akitsu Masuda, Hiroaki Mon, Tadashi Ueda, Takahiro Kusakabe. Effective expression and characterization of the receptor binding domains in SARS-CoV-2 Spike proteins from original strain and variants of concern using Bombyx mori nucleopolyhedrovirus in silkworm. Protein Expression and Purification. 2024. 218. 106450-106450
Hibiki Hakata, Yuki Takai, Jae Man Lee, Takahiro Kusakabe, Hina Satone, Yohei Shimasaki, Yuji Oshima. Tributyltin-binding protein type 1 (fish acid glycoprotein) is a potential gatekeeper of ethinylestradiol action in fish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2023. 271. 109660-109660
Kohei Kakino, Hiroaki Mon, Takeru Ebihara, Masato Hino, Akitsu Masuda, Jae Man Lee, Takahiro Kusakabe. Comprehensive Transcriptome Analysis in the Testis of the Silkworm, Bombyx mori. Insects. 2023. 14. 8. 684-684
Takeyuki Goto, Tomoki Sasaki, Yong Chong, Masahiro Taniguchi, Jae Man Lee, Akitsu Masuda, Takeru Ebihara, Kenichiro Shiraishi, Naoki Tani, Akiko Yonekawa, et al. SARS-CoV-2 strain-specific anti-Spike IgG ELISA utilizing spike protein produced by silkworms. Human Antibodies. 2023. 1-7
Akihiro Morio, Jae Man Lee, Tsuguru Fujii, Hiroaki Mon, Akitsu Masuda, Kohei Kakino, Jian Xu, Yutaka Banno, Takahiro Kusakabe. The biological role of core 1β1-3galactosyltransferase (T-synthase) in mucin-type O-glycosylation in Silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 2023. 156. 103936-103936

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MISC (146)：

前田麻亜子, 坪田拓也, 門宏明, 増田亮津, 松田拓也, 浅野眞一郎, 伴戸久徳, 瀬筒秀樹, 瀬筒秀樹, 荒川和晴, et al. Transplanting the Human TBX5 Regulatory Elements: In Silico Screening and Evaluation of Transcription Factors Independent of Bombyx mori Transcriptional Regulation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
藤井告, 柿野耕平, 李在萬, 日下部宜宏, 伴野豊. カイコのXDH遺伝子へのFLAGタグ配列のノックイン. 蚕糸・昆虫機能利用学術講演会・日本蚕糸学会大会講演要旨集. 2023. 93rd
柿野耕平, 門宏明, 佐藤昌直, 藤井告, 日野真人, 李在萬, 藤田龍介, 日下部宜宏. カイコ精巣をモデルとした配偶子形成に関与するカオナシ遺伝子の解析. 蚕糸・昆虫機能利用学術講演会・日本蚕糸学会大会講演要旨集. 2022. 92nd
柿野耕平, 門宏明, 日下部宜宏. Transcriptome analysis for basis of research on spermatogenesis in silkworm, Bombyx mori. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
村田亜未, 里圭太, 玉城志博, 新川武, 増田亮津, 李在萬, 日下部宜宏, 宮田健. カイコ発現系による細菌性毒素を応用した粘膜ワクチン用アジュバントの構築と機能性評価. 日本食品科学工学会西日本支部大会講演要旨. 2022. 2022

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Patents (5)：

Education (4)：

1988 - 1990 Kyushu University
- 1990 Kyushu University Graduate School, Division of Agriculture
1984 - 1988 Kyushu University School of Agriculture
- 1988 Kyushu University Faculty of Agriculture

Professional career (1)：

Doctor of Philosophy (Kyushu University)

Work history (9)：

2011/09 - 現在 Kyushu University
2004/10 - 2011/08 Kyushu University
1997/11 - 2004/09 Kyushu University School of Agriculture
1995 - 1998 Harvard Medical School, Post doctoral fellow
1995/04 - 1997/10 Harvard University

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Committee career (2)：

2014/04 - 現在日本蚕糸学会理事
2013/04 - 2017/03 日本蚕糸学会九州支部長

Awards (2)：

2019 - 大日本蚕糸会貞明皇后記念蚕糸科学賞九州大学保存蚕系統を活用したタンパク質高生産に関する技術開発
2017 - 日本蚕糸学会日本蚕糸学会賞昆虫ゲノムDNAの安定化・維持機構に関する研究

Association Membership(s) (2)：

日本分子生物学会 , 日本蚕糸学会

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