MARUYAMA TAKASHI

Homepage URL (1)： https://app.jove.com/methods-collections/1067/current-methods-in-intestinal-homeostasis-research

Research field (2)： Allergies and connective tissue disease , Immunology

Research keywords (3)： IκB-ζ , Gene rergulation , Immunology

Research theme for competitive and other funds (12)：

2018 - 2023 Association between pathogenic Th17 in periodontal disease and rheumatoid arthritis onsets.
2016 - 2019 Biological regulation by Galpha12/13-mediated lipid mediator function
2015 - 2017 シェーグレン症候群を引き起こす自己応答性T細胞の探索
2014 - 2016 Molecular mechanisms of Nuclear IkappaB family proteins control immune maturation.
2016 - プロポリス成分による自己免疫疾患の治療と予防効果の検証

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Papers (46)：

Takashi MaruYama, Hirofumi Miyazaki, Taishi Komori, Shion Osana, Hiroyuki Shibata, Yuji Owada, Shuhei Kobayashi. Curcumin analog GO-Y030 inhibits tumor metastasis and glycolysis. The Journal of Biochemistry. 2023. 174. 6. 511-518
MaruYama T, Miyazaki H, Lim YJ, Gu J, Ishikawa M, Yoshida T, Chen W, Owada Y, Shibata H. Pyrolyzed Deketene Curcumin Controls Regulatory T Cell Generation and Gastric Cancer Metabolism Cooperate With 2-Deoxy-D-Glucose. Frontiers in Immunology (T Cell Biology). 2023. 14. 1049713
Tomohiko Murakami, Yoshifumi Takahata, Kenji Hata, Kosuke Ebina, Katsutoshi Hirose, Lerdluck Ruengsinpinya, Yuri Nakaminami, Yuki Etani, Sachi Kobayashi, Takashi Maruyama, et al. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Science Signaling. 2022. 15. 758. eabl5304
Hideki Ishikawa, Morisada Hayakawa, Nemekhbayar Baatartsogt, Nao Kakizawa, Hiromi Ohto-Ozaki, Takashi Maruyama, Kouichi Miura, Koichi Suzuki, Toshiki Rikiyama, Tsukasa Ohmori. IκBζ regulates the development of nonalcoholic fatty liver disease through the attenuation of hepatic steatosis in mice. Scientific Reports. 2022. 12. 11634. 11634-11634
Tomoki Sasaki, Hiroyuki Nagashima, Atsushi Okuma, Takeshi Yamauchi, Kenshi Yamasaki, Setsuya Aiba, Takanori So, Naoto Ishii, Yuji Owada, Takashi MaruYama, et al. Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis. Digestive Diseases and Sciences. 2022. 67. 4. 1252-1259

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MISC (9)：

丸山貴司, 宮崎啓史, 大和田祐二. 関節リウマチにおける慢性炎症の制御. BIO Clinica 2024年 2月号膠原病診療と分子標的薬 update 第39巻第2号. 2024. 160-162
丸山貴司. 転写因子IκB-ζを介した関節リウマチの慢性化. 膠原病(別冊 BIO Clinica 慢性炎症と疾患通巻31号第12巻第2巻). 2023. 81-83
Takashi MaruYama, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata. Mono-Carbonyl Curcumin Analogs for Cancer Therapy. Biological and Pharmaceutical Bulletin. 2023. 46. 6. 756-763
MaruYama T, Chen W, Shibata H. TGF-β and Cancer Immunotherapy. Biol. Pharm. Bull 【Featured Article】. 2022. 45. 2. 155-161
Takashi MaruYama. The nuclear I kappa B family of proteins controls gene regulation and immune homeostasis. INTERNATIONAL IMMUNOPHARMACOLOGY. 2015. 28. 2. 836-840

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Patents (1)：

整理番号:R0502031

Books (1)：

IkappaB (pp.2600-2604)
Encyclopedia of Signaling Molecules, 2nd Edition (Springer) 2016

Lectures and oral presentations (39)：

高病原性Th17細胞の実態解明 (口頭発表)
(第32回東京免疫フォーラム(東京大学医科学研究所1号棟) 2024)
クルクミンアナログを用いた炎症制御機構(2OamE-09)(口頭発表)
(第129回日本解剖学会総会(沖縄なはーと) 2024)
British Journal of Pharmacology (Reviewer Certificate)
熱変性クルクミン誘導体は 2-deoxy-glucose 併用で糖代謝を抑えて制御性 T 細胞を制御する
(第61回日本癌治療学会学術集会(横浜) 2023)
Potential booster for checkpoint inhibitor
(NIDCR Data Session 2022)

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Professional career (2)：

博士(薬学)甲第192号接触性皮膚炎モデルの感作過程におけるフタル酸エステルのアジュバント作用とTRP受容体を介した神経刺激作用の関係2007年3月23日 (静岡県立大学)
修士(理学)PCRを用いたウシ乳汁中細菌の迅速同定法の確立および乳房炎診断への応用生命修第87号・2004年3月20日

Work history (15)：

2022/04 - 2025/03 千葉大学薬学研究科客員准教授
2024/04 - 東北大学未踏スケールデータアナリティクスセンター客員研究員
2021/10 - 2024/03 東北大学医学系研究科非常勤講師
2019/07 - 2020/03 Tohoku University Graduate School of Medicine (Japan); Visiting Researcher
2019/06 - 2020/03 University of Shizuoka Graduate School of Pharmaceutical Sciences (Japan); Visiting Researcher

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Committee career (4)：

2021/02 - 現在 Frontiers in Immunology (T cell Biology) Associate Editor
2023/01 - 2023/06 IRP Recruiter Academy (NIH, NIH Virtual Scientific Recruitment Summit)
2020/06 - 2021/02 Frontiers in Immunology (T cell Biology) Review Editor
2017/07 - 2020/01 Akita Igaku (Akita University, Schoolf of Medicine, Japan) Board Member

Awards (11)：

2024/03 - 東京免疫フォーラム東京免疫フォーラム研究奨励賞(2024.03.26)
2018/05 - Encouraging Research Award from Japanese Biochemical Society (Tohoku Branch), Japan
2017/11 - Akita Wakasugi Science and Technology Encouragement Award (Japan)
2016/06 - Novo Nordisk International Travel Bursary for the 16th ICI (International Congress of Immunology)
2015/07 - The Federation of Immunological Societies of Asia-Oceania (FIMSA) 6th Congress in Singapore (Travel Fellowship)

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