2020 - 2023 Strategy for dementia prevention based on the gut microbiota-brain axis on cognitive flexibility
2020 - 2023 Regulation of incretin secretion by microbiota metabolites
2019 - 2023 行動制御の性差を生み出す神経メカニズムの解明
2020 - 2022 Elucidation of chemical communication between microbiota and enteroendocrine cells
2020 - 2022 Elucidation of the metabolic regulation mechanism of neurons
2017 - 2021 Molecular mechanisms of gastrointestinal hormone secretion by intestinal bacterial metabolites
2018 - 2020 Microbial regulation of hormone secretion from enteroendocrine
2016 - 2020 Development of genetically-encoded multi-color biosensors for intracellular signaling
2014 - 2018 Function and dynamics of stress-induced lncRNA
2014 - 2018 Molecular mechanisms of ghrelin secretion from endocrine cells
2015 - 2017 Apply for induced pluripotent stem cells in forensic practice
2013 - 2017 Development of genetically-encoded multi-color ATP sensors for clarification of energy metabolism.
2012 - 2015 Diagnosis of Drug Induced arrhythmia
2012 - 2014 Mechanisms of gliotransmitter release from astrocytes by imaging analysis
2010 - 2012 The development of the forensic pathological method for diagnosis about chronic stress
2009 - 2010 Study on the molecular mechanism of hormone secretion
2006 - 2008 Molecular mechanisms of hormone release revealed by live cell imaging analysis
1998 - 2000 光学的手法によるトランスミッター放出機構の解析
1998 - 1999 The role of mitochondrial dysfunction in the process of glutamate neurotoxicity
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Papers (97):
Saki Tsuno, Kazuki Harada, Mina Horikoshi, Marie Mita, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi. Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. FEBS open bio. 2024. 14. 1. 79-95
Mina Horikoshi, Kazuki Harada, Saki Tsuno, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Shin Terada, Takashi Tsuboi. Distinct lactate metabolism between hepatocytes and myotubes revealed by live cell imaging with genetically encoded indicators. Biochemical and biophysical research communications. 2023. 694. 149416-149416
Kazuki Harada, Maoko Takashima, Tetsuya Kitaguchi, Takashi Tsuboi. Exocytotic dynamics of glucagon-like peptide-1 from enteroendocrine L cell line is regulated by actin polymerization. 2022
Mai Takizawa, Yuri Osuga, Rika Ishida, Marie Mita, Kazuki Harada, Hiroshi Ueda, Tetsuya Kitaguchi, Takashi Tsuboi. Development of a red fluorescent protein-based cGMP indicator applicable for live-cell imaging. Communications Biology. 2022. 5. 1
Yuri Osuga, Kazuki Harada, Takashi Tsuboi. Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Biochemical and biophysical research communications. 2022. 588. 118-124