Sugiura Tsuyoshi

2020 - 2023 Development of biomarkers targeting myeloid-derived suppressor cells in oral cancer precision medicine

2019 - 2022 口腔・大腸マイクロバイオーム解析による大腸がんリスク診断および予防概念の創生

2019 - 2022 うがい液試料の統合的マルチオミクス解析に基づく口腔癌プレシジョン治療の実現

2018 - 2021 Decelopment of nect generation precision theraoy for oral cancer by single cell analysis of oral cancer CTCs

2018 - 2021 Functional analysis and therapeutic development of stem cell genes in distant metastasis through vascular infiltration of oral cancer

2018 - 2020 AIを実装した嚥下機能検査によるオーラルフレイルの評価の実証研究

2016 - 2019 Significance of hypoxia-responsive cancer stem cell markers in invasion and metastasis of oral cancer

2016 - 2019 Development of Precision Medicine by recovery of CTCs from circulating blood in oral cancer

2016 - 2018 The development of the precision medicine using the real-time liquid biopsy with the circulation cancer cell separation of oral cancer

2016 - 2018 Development of oral cancer therapy utilizing the regulation of CD82 expresssion, a suppressor of metastasis, by microRNA.

2015 - 2018 Devlopment of novel oral cancer treatment with non-coding RNA by targetting metastatic organ and cancer stem cells.

2015 - 2018 Noninvasive detection of oral cancer and precancerous lesion using aberrant DNA methylation in gargle fluid samples

2015 - 2017 A development of gene delivery system that enable to making early diagnosis and inhibiting metastasis.

2013 - 2016 Epithelial mesenchymal transition induced invasion and metastasis in oral squamous cell carcinoma via delta-Np63.

2012 - 2014 Establishment of salivary gland regeneration method using salivary gland tissue-originated spheroid (STOS)

2011 - 2014 Developing of differentiation inducing therapy on oral cancer by targeting transcription factor Brachyury which regulates cancer stem cells

2010 - 2011 Isolation of salivary gland stem cells and establishment of salivary gland regeneration method with tissue niche.

2008 - 2010 Isolation of oral cancer stem cells and development of new therapies targeted cancer stem cells.

2008 - 2009 細胞の自己組織構築能を利用した唾液腺再生法の開発

2006 - 2008 Development of new oral cancer therapy utilizing the metastasis suppressing effect of transmembrane 4 super-family protein, tetraspanin

2006 - 2007 Three-dimensional analysis of testraspanin that mediates tumor-extracellular matrix interaction

2004 - 2006 Therapeutic approaches, including molecularly targeted therapies The inhibition of invasion and metastasis of oral cancers by molecularly targeted therapies Search for novel therapy and molecular pathogenesis of oral cancer metastasis

2003 - 2005 癌転移抑制因子テトラスパニンCD9,CD82による口腔癌転移抑制療法の開発

2001 - 2002 ESTABLISHMENT AND APPLIANCE OF NEWLY GENE THERAPY FOR INHIBITION OF MULTIDRUG RESISTANCE

2000 - 2002 Search for molecular targets involved in oral tumor invasion

2000 - 2001 唾液腺癌浸潤を制御するインテグリン分子の機能解析

癌細胞のシグナル伝達機構

口腔癌細胞の浸潤機構の解析

Signal transduction mechanisms of the Cancer Cells

Analysis of the mechanism of Oral Cancer Cell invasion