Rchr
J-GLOBAL ID：200901007166121666
Update date: Apr. 04, 2024
Takahashi Hideyo
タカハシ ヒデヨ | Takahashi Hideyo
Affiliation and department：
Job title：
Professor
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research keywords (1)：
axial chilarity, carbohydrate chemistry, Menkes disease,
Research theme for competitive and other funds (36)：
- 2022 - 2025 新規メンケス病治療薬創製を目指した銅錯体の体内動態および薬効の検討
- 2022 - 2025 Photoreaction of thioamides and its application to medicinal chemistry
- 2019 - 2022 Stereochemistry of N-S/N-N bond and its application to medicinal chemistry
- 2018 - 2022 Pharmacokinetics and pharmaceutics investigation on copper complex to development an oral therapeutic agent for Menkes disease.
- 2018 - 2021 Accurate measurement of natural toxins in body fluids using deuterated standards and search of specific markers for the rapid diagnosis
- 2016 - 2019 Copper supplement therapy based on a developmental change in copper metabolism in Menkes disease.
- 2015 - 2018 Development of the drug candidates with atropisomeric property
- 2015 - 2018 Radionuclide-carrying liposomes with both high tumor accumulation and rapid background clearance
- 2015 - 2018 Development of novel hypoxia imaging probes with a novel retention mechanism and high versatility
- 2012 - 2015 Development of bioactive compounds containing sugar moiety
- 2011 - 2014 Ultrasound cancer therapy in next-generation with liposomal nanobubbles having both functions of diagnostics and therapeutics
- 2009 - 2011 Development of novel sugar-related organic compounds utilized for the elucidation of life phenomenon.
- 2007 - 2008 Development of novel sugar-related organic compounds involved in insulin signaling mechanism
- 2006 - 2007 新しい生体機能を有する糖関連化合物の創製
- 2005 - 2006 Development of a novel sugar linkage and its application to the synthesis of bloactive compounds.
- 2005 - 2005 新規糖鎖構築法の開発と生物活性物質への合成応用
- 2004 - 2005 Design and Synthesis of Highly Bioactive Sugar-Related Substances
- 2003 - 2004 Development of a novel sugar linkage and sugar-related bioactive compounds
- 2002 - 2003 糖変換に基づく生物活性物質の合成
- 2001 - 2003 Design and Synthesis of Highly Bioactive Sugar-Related Substances
- 2001 - 2001 糖変換に基づく生物活性物貭の合成
- 2000 - 2001 D-糖ラクトン体を用いるL-糖の新規合成法の開発
- 1997 - 1999 Design and Synthesis of New Bioactive Substances directed to Drug Discovery
- 1998 - 1998 糖変換に基づく天然物及び関連物質の合成
- 1997 - 1997 糖変換に基づく天然物及び関連物質の合成
- 1996 - 1997 Stereoselective Glycosylation via Decarboxylation of Mixed Carbonate
- 1995 - 1996 Molecular Desing and Synthesis of New Bioactive Substances
- 1994 - 1995 A Steroselective Synthesis of Sialic Acid Derivatives Suitable for Glycosidation Reaction
- 1993 - 1994 Molecular Design and Synthesis of Biologically Important Substances
- 軸不斉に基づく構造活性研究
- エーテル結合糖の創製
- L-糖の合成法の開発
- 多置換シクロヘキサノンの立体選択的合成法の開発
- Synthesis of ether-linked sugar
- Synthesis of L-Sugars.
- Study on Stereoselective synthesis of chiral Substituted Cyclohexanones.
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Papers (125)：
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Kenjiro Okubo, Toshiyuki Kudo, Sae Yoshihara, Yu Nakabayashi, Kana Nakauchi, Akimi Tanaka, Moe Saito, Ayumi Tsujisawa, Hitomi Goda, Yoshiaki Yamagishi, et al. Physiologically based pharmacokinetic model analysis of the inhibitory effect of vonoprazan on the metabolic activation of proguanil. Drug Metabolism and Pharmacokinetics. 2024. 54. 100537-100537
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Shoichi Nishimoto-Kusunose, Ayaka Hirakawa, Asuka Tanaka, Kazumi Yoshizawa, Kosho Makino, Hideyo Takahashi, Tatsuya Higashi. Drugs possessing aryloxypropanamine pharmacophore, duloxetine, dapoxetine and propranolol, increase allopregnanolone in rat brain: Possible involvement of allopregnanolone in their central nervous system effects. Steroids. 2023. 198. 109272-109272
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Arisa Chiba, Ryoko Tanaka, Mayuno Hotta, Kayo Nakamura, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Hideyo Takahashi. Stereochemistry of N-Acyl-5H-dibenzo[b,d]azepin-7(6H)-ones. Molecules. 2023. 28. 12. 4734-4734
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Yan Li, Chinatsu Ohtake, Mayuno Hotta, Hidetsugu Tabata, Kiriko Hirano, Motoo Iida, Kayo Nakamura, Kosho Makino, Tetsuta Oshitari, Hideaki Natsugari, et al. Stereochemical Analysis of Trifluoroacetamide Derivatives Based on Through-Space 1H-19F Spin-Spin Couplings. The Journal of Organic Chemistry. 2023. 88. 11. 7026-7037
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Kumi Tozawa, Kosho Makino, Yuki Tanaka, Kayo Nakamura, Akiko Inagaki, Hidetsugu Tabata, Tetsuta Oshitari, Hideaki Natsugari, Noritaka Kuroda, Kunio Kanemaru, et al. Conversion of Racemic Alkyl Aryl Sulfoxides into Pure Enantiomers Using a Recycle Photoreactor: Tandem Use of Chromatography on Chiral Support and Photoracemization on Solid Support. The Journal of Organic Chemistry. 2023
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MISC (107)：
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高橋秀依、夏苅英昭. セレンディピティ-と創薬(3)-ベンゾジアゼピン類とリュープロレリンの誕生-. 都薬雑誌. 2022. 44. 10. 10-13
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高橋秀依、夏苅英昭. セレンディピティ-と創薬(2)-シスプラチンの発見・発明とその化学-. 都薬雑誌. 2022. 44. 9. 46-49
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高橋秀依、夏苅英昭. セレンディピティ-と創薬-ペニシリンの発見・発明とその化学-. 都薬雑誌. 2022. 44. 8. 9-13
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高橋秀依、夏苅英昭. シャンプーとコンディショナー(リンス)の違い-界面活性剤の化学-. 都薬雑誌. 2022. 44. 7. 10-13
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高橋秀依、夏苅英昭. 新型コロナウイルス感染症(COVID-18)の治療薬(2). 都薬雑誌. 2022. 44. 6. 36-39
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Patents (1)：
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スルホキシド化合物のエナンチオマー調製方法及びエナンチオマー調製システム
Books (12)：
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現場で役に立つ!臨床医薬品化学
化学同人 2021 ISBN:9784759820546
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注射薬調剤監査マニュアル2021
エルゼビアジャパン 2020 ISBN:9784860343521
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くすりに携わるなら知っておきたい!医薬品の化学
じほう 2019 ISBN:9784840752459
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知っておきたい有機反応100 第2版
東京化学同人 2019 ISBN:9784807909605
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注射薬調剤鑑査マニュアル2018
エルゼビア・ジャパン 2018 ISBN:9784860342296
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Lectures and oral presentations (115)：
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4位置換5H-dibenz[b,f]azepineのN-alkyl/aryl化体の立体構造の解明
(日本薬学会第142年会 2022)
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フェンタニル誘導体の合成と構造活性相関
(日本薬学会第142年会 2022)
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キラルスルホキシドの光ラセミ反応における照射量の検討
(日本薬学会第142年会 2022)
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トリアゾロベンゾジアゼピン誘導体の立体構造の解明
(日本薬学会第142年会 2022)
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Atropisomeric properties of 9-methyl-1,4-benzodiazepin-2-ones
(AIMECS2021 2021)
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Education (3)：
- - 1994 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences Pharmaceutical Sciences
- - 1994 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences Pharmaceutical Sciences
- - 1989 The University of Tokyo Faculty of Pharmaceutical Science Pharmaceutical Sciences
Professional career (1)：
- Ph.D in Pharmaceutical Sciences (The University of Tokyo)
Work history (5)：
- 2006/04 - 2018/03 Teikyo University Faculty of Pharma Sciences Professor
- 2003/04 - 2006/03 Teikyo University Faculty of Pharma Sciences Associate Professor
- 2000/02 - 2003/03 Teikyo University Faculty of Pharma Sciences Lecturer
- 1994/04 - 2000/02 Teikyo University Faculty of Pharma Sciences Assistant Professor
- 1992/04 - 1994/03 Japan Society for the Promotion of Science Research Fellow
Committee career (8)：
- 2019/04/01 - 2021/03/31 有機合成化学協会 関東支部幹事
- 2019/04/01 - 2021/03/31 日本薬学会医薬化学部会 常任世話人
- 2018/04/01 - 2020/03/31 有機合成化学協会 代議員
- 2017/04/01 - 2019/03/31 有機合成化学協会 関東支部常任幹事
- 2016/04/01 - 2018/03/31 有機合成化学協会 代議員
- 2006/04/01 - 2017/03/31 The Pharmaceutical Society of Japan Med Chem News 編集委員
- 2006/04/01 - 2017/03/31 日本薬学会 学会誌及び論文誌の編集者
- 2014/04/01 - 2016/03/31 有機合成化学協会 代議員
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Awards (3)：
- 2019/06/30 - 平成30年度特別研究員等審査会専門委員(書面担当)及び国際事業委員会書面審査員表彰
- 2018/09/30 - 平成28年度特別研究員等審査会専門委員(書面担当)書面審査員表彰
- 2002/03/28 - The PSJ Award for Young Scientists
Association Membership(s) (3)：
The society of Synthetic Organic Chemistry, Japan
, The Pharmaceutical Society of Japan
, The Pharmaceutical Society of Japan
