Hijikata Makoto

ヒジカタマコト | Hijikata Makoto

Affiliation and department：
Job title： Associate Professor,Associate Professor

Research field (1)： Virology

Research keywords (6)：細胞生物学 , 分子生物学 , ウイルス学 , Cell Biology , Molecular Biology , Virology

Research theme for competitive and other funds (17)：

2015 - 2018 Study on the regulatory mechanisms of infectious particle formation of hepatitis C virus by arachidonic acid cascade
2012 - 2014 Study on the infection and proliferation of HCV during hepatic differentiation of human hepatic stem cells
2007 - 2008 Study on the molecular mechanisms of hepatitis C viral particle production
2007 - 2008 Immunosuppression and strategies for prevention of HCV recurrence after liver transplantation based on preoperative T cell subset analysis
2004 - 2005 Structural and functional studies on replication complex for hepatitis C viral genome

Show all

Papers (144)：

Kazuki Ohya, Michio Imamura, Yuji Teraoka, Takuro Uchida, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, et al. Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-infected human hepatocyte transplanted mice. Biochemical and biophysical research communications. 2021. 559. 78-83
Yuichi Akahori, Hiroki Kato, Takashi Fujita, Kohji Moriishi, Yasuhito Tanaka, Koichi Watashi, Michio Imamura, Kazuaki Chayama, Takaji Wakita, Makoto Hijikata. Establishment of a novel hepatitis B virus culture system using immortalized human hepatocytes. Scientific reports. 2020. 10. 1. 21718-21718
Yohei Miyayama, Heini Lee, HoJoong Song, Hiromi Abe-Chayama, Daiki Miki, Michio Imamura, Kazuaki Chayama, Makoto Hijikata. Comparative study on the replication of HCV1b genome between wild-type and cell culture-adaptive mutant in regard to sensitivities against anti-HCV drugs. Microbiology and Immunology. 2020. 64. 4. 296-303
Fumihiro Kato, Yasunori Nio, Kazumi Yagasaki, Rieko Suzuki, Makoto Hijikata, Tomoyuki Miura, Isao Miyazaki, Shigeru Tajima, Chang-Kweng Lim, Masayuki Saijo, et al. Identification of inhibitors of dengue viral replication using replicon cells expressing secretory luciferase. Antiviral research. 2019. 172. 104643-104643
Yasunori Nio, Machiko Sasai, Yuichi Akahori, Hitomi Okamura, Hikari Hasegawa, Mizuki Oshima, Koichi Watashi, Takaji Wakita, Akihide Ryo, Yasuhito Tanaka, et al. Bardoxolone methyl as a novel potent antiviral agent against hepatitis B and C viruses in human hepatocyte cell culture systems. Antiviral research. 2019. 169. 104537-104537

ｍore...

MISC (106)：

Mitsutaka Osawa, Michio Imamura, Takuro Uchida, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, et al. RESISTANCE ANALYSIS FOR GLECAPREVIR AND PIBRENTASVIR ON GENOTYPE 1b HEPATITIS C VIRUS INFECTION IN SUBGENOMIC REPLICON SYSTEMS AND HUMAN HEPATOCYTE TRANSPLANTED MICE. HEPATOLOGY. 2019. 70. 988A-989A
MIYAYAMA Yohei, CHAYAMA Hiromi, MIKI Daiki, IMAMURA Michio, CHAYAMA Kazuaki, HIJIKATA Makoto. Development of novel recombinant HCV1b culture system. 第65回日本ウイルス学会学術集会.大阪. 2017
OKAMURA Hitomi, NIO Yasunori, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto. Fatty acids synthesized from cellular fatty acid synthesis pathway play roles in hepatitis B virus production. 第65回日本ウイルス学会学術集会.大阪. 2017
OKAMURA Hitomi, MIYAYAMA Yohei, AKAHORI Yuichi, HIJIKATA Makoto. Modulation of HBV life cycle by Sulforaphane. 2017 International meeting on the molecular biology of hepatitis B viruses, Washington D.C., USA. 2017
OKAMUARA Hitomi, NIO Yasunori, WATASHI Koichi, WAKITA Takaji, HIJIKATA Makoto. Fatty acids with certain carbon chain length can support hepatitis B virus production. 2017 International meeting on the molecular biology of hepatitis B viruses, Washington D.C., USA. 2017

ｍore...

Patents (14)：

Method for Producing Epithelial Stem Cells
内胚葉性幹細胞の製造方法
感染性C型肝炎ウイルス粒子の製造方法、およびその利用
肝炎ウイルスの増殖方法、及びその利用
上皮系体性幹細胞の製造方法

ｍore...

Books (4)：

3D細胞培養系を用いた患者血液由来HCV培養
肝・胆・膵 57 (5), 679-687 2008 2008
HCVと肝発癌
医学のあゆみ 224 (9), 693-698 2008 2008
C型肝炎ウイルスの生活環と発がん
公益社団法人日本農芸化学会 2008
C型肝炎ウイルス(共著)
アイピーシー, 2000

Lectures and oral presentations (6)：

Development and application of hepatitis virus culture system
(Meet the expert 2016)
HCV培養系開発から見出された新たなHCV薬の標的
(第27回広島肝臓研究会学術講演会 2014)
C型肝炎治療薬の新たな分子標的の探索
(第13回肝疾患フォーラム学術集会 2013)
Novel targets for anti HCV drugs preventing infectious virus particle production.
(The 3rd JCA-AACR Special Joint Conference, The Latest Advances in Liver Cancer Research: From Basic Science to Therapeutics, Chiba, Japan 2011)
ウイルス培養系を用いたC型肝炎ウイルスの性状と病原性の解明、臨床分離HCV株の培養と性状
(第58回日本ウイルス学会学術総会徳島 2010)

ｍore...

Education (4)：

- 1988 Shinshu University
- 1988 Shinshu University Graduate School, Division of Medicine
- 1982 Shinshu University Faculty of Science
- 1982 Shinshu University Faculty of Science

Professional career (2)：

Doctor of Medicine (Shinshu University)
Master of Science (Shinshu University)

Work history (9)：

1994 - 1997 国立がんセンター研究所室長
1994 - 1997 Section Head, National Cancer Center Research Institute
1997 - - Associate Professor, Institute for Virus Research, Kyoto University
1994 - 1996 米国ロックフェラ?大学博士研究員
1994 - 1996 Postdoctoral Fellow, The Rockefeller University, NY, USA

Show all

Association Membership(s) (4)：

日本生化学会 , 日本癌学会 , 日本分子生物学会 , 日本ウイルス学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page