Rchr
J-GLOBAL ID:200901007575791886
Update date: Jan. 31, 2024
Maruyama Atsushi
マルヤマ アツシ | Maruyama Atsushi
Affiliation and department:
Job title:
Professor
Research field (4):
Polymer chemistry
, Molecular biochemistry
, Biomaterials
, Biomedical engineering
Research keywords (7):
DDS
, bioconjugate
, biofunctional materials
, genotyping
, DNA
, Cationic copolymer
, バイオコンジュゲート 核酸工学 生体機能性材料
Research theme for competitive and other funds (42):
- 2021 - 2024 Generation of novel bimolecular functions with artificial chaperone engineering
- 2015 - 2020 Polymer nano assembly for innovative functional controls of biomolecules
- 2016 - 2019 Design of photo-responsive ureido polymers
- 2015 - 2018 Single molecule level analysis of dynamics of super-coild DNA
- 2013 - 2016 Design of polypeptide showing UCST-type phase transition behavior
- 2011 - 2016 Evaluation of cellular functions by imaging cellular nucleic acids
- 2011 - 2016 Nanomedicine Molecular Science
- 2011 - 2015 Polymer materials design to engineer assembly and function of biopolymers
- 2010 - 2012 Development of high stable biodegradable polyion complex-coated polymeric micelles as drug carriers
- 2008 - 2010 PEG-grafted linear cationic polymer for tumor accumulation and cell penetration
- 2008 - 2010 Nucleic acid-based nanomachine systems for tumor treatment
- 2004 - 2009 Development of simple method for genotyping
- 2006 - 2007 免疫疾患治療を目指した効率的寛容誘導法としてのネオグリコ抗原開発
- 2004 - 2007 Novel nucleic acids nanobiotechnology integrated with materials science
- 2005 - 2006 核酸シャペロン機能を持つ高分子材料設計と核酸ナノテクノロジーへの応用
- 2003 - 2005 Genetic Manipulation of Sinusoidal Endothelial Cells
- 2004 - 新しい遺伝子診断法の開発
- 2001 - 2002 Kidney-targeted plasmid DNA transfer by retrograde renal vein injection
- 2001 - 2002 分子シンクロ機能を有するナノ会合体による遺伝子デリバリー
- 2000 - 2002 Physiological microenvironment-responsive contrast agent for magnetic resonance imaging
- 2000 - 2002 Polycationic copolymers having stabilizing activity toward triplex DNA
- 1998 - 2002 Molecular Synchronization for Design of New Materials System
- 2000 - 2000 生理的条件での効率的な三重鎖DNA形成によるがん遺伝子の発現制御
- 1997 - 1999 Design of Polymeric Supramolecular-assembly for Targeted Therapy of Liver
- 1997 - 1998 3重鎖DNA安定化能を有するポリカチオングラフト共重合体の設計
- 1997 - 1998 Design of a cell specific macromolecular contrast agent for higher resolution of magnietic resonance imaging
- 1996 - 1997 DESIGN OF CELL SPECIFIC CARRIERS FOR GENES AND PEPTIDES
- 1995 - 1997 Development of Superasialoglycoprotein models with combined functions of Liver-cells Recognition and Drugs-inclusion
- 1995 - 1995 糖脂質モデルによる糖鎖組織構造の制御と細胞機能制御
- 1993 - 1994 Application of biodegradable Nanoparticles coated with sugar-carrying polymer to targetted drug delivery
- 1992 - 1992 細胞特異性を有する遺伝子運搬体としての配糖高分子の合成と機能評価
- 1990 - 1990 表面構造を制御した高分子材料上での細胞の応答と機能
- 1990 - 1990 ポリアミノ酸誘導体の高次組織化膜による光学異性体の認識と分離
- 1989 - 1990 血液細胞を機構制御する抗血栓性高分子材料の合成と評価
- 1987 - 1989 Structural Effects of Ion Transport in Macromolecules
- 1987 - 1987 優れた抗血栓性と物質透過性を有する複合的生体機能性材料の開発
- Stabilization of DNA duplex and triplex
- Development of Intelligent Drug Delivery System
- Design of cellular Specific gene Carrier
- 2重鎖・3重鎖DNAの安定化
- インテリジェント型ドラッグデリバリーシステムの開発
- 細胞特異的遺伝子キャリアーの設計
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Papers (254):
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Shuya Fan, Tadao Takada, Atsushi Maruyama, Mamoru Fujitsuka, Kiyohiko Kawai. Programmed Control of Fluorescence Blinking Patterns based on Electron Transfer in DNA. Chemistry - A European Journal. 2023. 29. 19
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Shuya Fan, Tadao Takada, Atsushi Maruyama, Mamoru Fujitsuka, Kiyohiko Kawai. Large heterogeneity observed in single molecule measurements of intramolecular electron transfer rates through DNA. Bulletin of the Chemical Society of Japan. 2022. 95. 12. 1697-1702
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Tsukuru Masuda, Shutaro Takahashi, Takuro Ochiai, Takayoshi Yamada, Naohiko Shimada, Atsushi Maruyama. Autonomous Vesicle/Sheet Transformation of Cell-Sized Lipid Bilayers by Hetero-Grafted Copolymers. ACS Applied Materials & Interfaces. 2022
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Shuya Fan, Jie Xu, Yasuko Osakada, Katsunori Hashimoto, Kazuya Takayama, Atsushi Natsume, Masaki Hirano, Atsushi Maruyama, Mamoru Fujitsuka, Kumi Kawai, et al. Electron-transfer kinetics through nucleic acids untangled by single-molecular fluorescence blinking. Chem. 2022. 8. 11. 3109-3119
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Atsuhiro Kojima, Juki Nakao, Naohiko Shimada, Naoki Yoshida, Yota Abe, Yu Mikame, Tsuyoshi Yamamoto, Takehiko Wada, Atsushi Maruyama, Asako Yamayoshi. Selective Photo-Crosslinking Detection of Methylated Cytosine in DNA Duplex Aided by a Cationic Comb-Type Copolymer. ACS biomaterials science & engineering. 2022
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MISC (197):
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和田健彦, 上松亮平, 菅井祥加, 有吉順平, 山吉麻子, 荒木保幸, 坂本清志, 嶋田直彦, 丸山厚, 樫田啓, et al. 生体応答性を模倣した細胞内環境応答型人工核酸の開発と核酸医薬への展開. 高分子学会予稿集(CD-ROM). 2014. 63. 2. ROMBUNNO.3X10
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山吉麻子, 松山洋平, 有吉純平, 嶋田直彦, 和田健彦, 村上章, 丸山厚. カチオン性くし型共重合体を用いた核酸の光架橋反応の制御. 高分子学会予稿集(CD-ROM). 2014. 63. 2. ROMBUNNO.1PA107
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山吉麻子, 松山洋平, 有吉純平, 村上章, 和田健彦, 嶋田直彦, 丸山厚. カチオン性くし型共重合体の主鎖の化学構造が核酸シャペロン活性に与える影響. 高分子学会予稿集(CD-ROM). 2014. 63. 1. ROMBUNNO.2PA109
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Rui Moriyama, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama. Annealing activity of cationic comb-type copolymers for DNA assembly. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012. 243
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Yuichi Ohya, Shin-ya Takeda, Yosuke Shibata, Akihiro Takahashi, Yoshinori Morimoto, Arihiro Kano, Atsushi Maruyama. Polyion complex coated biodegradable block copolymer micelles as highly stable cell-specific drug carriers. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012. 243
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Books (20):
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Electrostatic interaction
Supramolecular design for biological applications 2002
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Electrostatic interaction
Supramolecular design for biological applications 2002
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Synthesis and chemical characterization of polylysine comb-type copolymers as site-specific DNA carriers,in"Non-viral vectors for gene theraph"
Methods in Molecular Medicine,Humana Press Inc. 2001
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Site-specific gene transfer with polylysine comb-type copolymers,in"Non-viral vectors for gene theraph"
Methods in Molecular Medicine,Humana Press Inc. 2001
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Duplex and Triplex stabilization by comb-type copolymers,in "Non-viral vectors for gene therapy"
Methods in Molecular Medicine,Humana Press Inc. 2001
more...
Education (4):
- - 1986 Tokyo University of Science Graduate School, Division of Engineering
- - 1986 Tokyo University of Science Graduate School of Engineering
- - 1982 Tokyo University of Science Faculty of Engineering
- - 1982 Tokyo University of Science Faculty of Engineering Industrial Chemistry
Professional career (1):
Work history (5):
- 2013/04 - 現在 Tokyo Institute of Technology School of Life Science and Technology Professor
- 2003 - Kyushu University Institute for Materials Chemistry and Engineering Professor
- 2000 - Tokyo Institute of Technology
- 1991 - Tokyo Institute of Technology
- 1987 - Sophia University
Committee career (4):
- 日本核酸医薬学会 評議委員
- 日本核酸化学会 評議委員
- 日本DDS学会 評議委員
- 日本バイオマテリアル学会 評議委員
Awards (8):
- 2020/08 - 日本DDS学会 永井賞
- 2018/09 - 日本油化学会 オレオサイエンス賞
- 2018/05 - Society of Polymer Science, Japan The Award of the Society of Polymer Science, Japan
- 2005 - 日本バイオマテリアル学会 学会賞(学術)
- 1998 - Intelligent Materials Forum, Takagi Award '98 for outstanding paper
- 1998 - Intelligent Materials Forum, Takagi Award '98 for outstanding paper
- 1997 - 1997 Jorge Heller Journal of Controlled Release/CRS outstanding paper award
- 1997 - 1997 Jorge Heller Journal of Controlled Release/CRS outstanding paper award
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Association Membership(s) (6):
日本DDS学会
, 日本バイオマテリアル学会
, 日本化学会
, 高分子学会
, NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN
, 日本核酸化学会
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