Rchr
J-GLOBAL ID:200901007706214677   Update date: Apr. 10, 2024

Nagano Shingo

ナガノ シンゴ | Nagano Shingo
Affiliation and department:
Job title: Research Scientist
Research field  (1): Structural biochemistry
Research keywords  (4): natural products biosynthesis ,  enzyme ,  X-ray crystallography ,  Structural Biology
Research theme for competitive and other funds  (23):
  • 2019 - 2024 酵素が巧みに織りなす化学反応過程のダイナミズムの撮像
  • 2020 - 2023 Elucidation of molecular basis of biosynthesis with the aim of expanding the diversity of natural products
  • 2020 - 2023 病原性細菌が嫌気的にヘムを開環分解して生存に必須の鉄を取り出す機構の解明
  • 2019 - 2021 ラダラン脂質の梯子状疎水基を構築する生合成マシナリーの構造基盤の解明
  • 2018 - 2021 Chemical biology research solves the 3W1H of tenuazonic acid
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Papers (68):
  • 池田 泰輝, 伊澤 正一郎, 佐藤 裕介, 永野 真吾, 日野 智也. 新規甲状腺癌バイオマーカーである抗WDR1抗体の高感度検出を目指したヒトWDR1の調製. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-662]
  • Takumi Kariya, Hayato Hasegawa, Taro Udagawa, Yusaku Inada, Kyoko Nishiyama, Mieko Tsuji, Tasuku Hirayama, Tatsuo Suzutani, Naoki Kato, Shingo Nagano, et al. Elucidation of the stereocontrol mechanisms of the chemical and biosynthetic intramolecular Diels-Alder cycloaddition for the formation of bioactive decalins. RSC advances. 2023. 13. 40. 27828-27838
  • Tesshin Uegaki, Taisei Takei, Shuhei Yamaguchi, Keisuke Fujiyama, Yusuke Sato, Tomoya Hino, Shingo Nagano. Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins. International journal of molecular sciences. 2023. 24. 1
  • Ryuhei Nagata, Hironori Suemune, Masaya Kobayashi, Tetsuro Shinada, Kazuo Shin-ya, Makoto Nishiyama, Tomoya Hino, Yusuke Sato, Tomohisa Kuzuyama, Shingo Nagano. Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-like Enzymes. Angewandte Chemie International Edition. 2022
  • Takaki Okamoto, Kazuya Yamanaka, Yoshimitsu Hamano, Shingo Nagano, Tomoya Hino. Crystal structure of the adenylation domain from an ε-poly-l-lysine synthetase provides molecular mechanism for substrate specificity. Biochemical and Biophysical Research Communications. 2022. 596. 43-48
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MISC (9):
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Lectures and oral presentations  (15):
  • デカリン骨格を構築するDiels AlderaseのX線結晶構造解析: 立体化学の制御メカニズ ムの解明を目指して
    (理研シンポジウム: デカリン化合物の化学合成と生合成 2019)
  • ブラシノステロイド生合成の構造生物学
    (第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会 2019)
  • Crystal structures of CYP90B1, a key enzyme in brassinosteroid biosynthesis
    (The 21st International Conference on Cytochrome P450: Biochemistry and Biophysics 2019)
  • Crystal structures of CYP90B1: insights into brassinosteroid biosynthesis and its inhibition
    (2018 International Meeting on 22nd MDO and 33rd JSSX 2018)
  • Structural insights into a key step of brassinosteroid biosynthesis
    (第56回日本生物物理学会年会 2018)
more...
Education (2):
  • - 1996 Kyoto University Graduate School of Engineering
  • - 1996 Kyoto University Graduate School, Division of Engineering Molecular Engineering
Professional career (1):
  • Ph.D.
Work history (7):
  • 2009/10 - 現在 Tottori University Graduate School of Engineering
  • 2007/04 - 2009/08 理化学研究所 播磨研究所 専任研究員
  • 2005/04 - 2007/03 理化学研究所 播磨研究所 先任研究員
  • 2004/11 - 2005/03 理化学研究所 播磨研究所 研究員
  • 2002/08 - 2004/10 カリフォルニア大学アーバイン校 博士研究院
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Awards (5):
  • 2023/02 - Tottori University Tottori University President's Award
  • 2012 - 長瀬科学技術振興財団 長瀬研究振興賞 インドールアルカロイドの構造多様性創出原理の解明
  • 2008/09 - 内藤記念科学振興財団 第22回内藤コンファレンスポスター賞 インドロカルバゾール生合成酵素の構造解析
  • 2005 - Journal of Biological Chemistry, Papers of the Week Crystallographic Study on the Dioxygen Complex of Wild-type and Mutant Cytochrome P450cam IMPLICATIONS FOR THE DIOXYGEN ACTIVATION MECHANISM
  • 2000 - Journal of Biochemistry 論文賞 X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: roles of Thr252 and water in the active center.
Association Membership(s) (10):
American Society for Biochemistry and Molecular Biology ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  アメリカ化学会 ,  日本化学会 ,  日本生化学会 ,  日本生物物理学会 ,  Japanese Biochemical Society ,  Biophysical Society of Japan ,  American Chemical Society ,  Chemical Society of Japan
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