Rchr

J-GLOBAL ID：200901007711071000 Update date: Apr. 12, 2024

Sugimoto Masahiro

スギモトマサヒロ | Sugimoto Masahiro

Affiliation and department：
Job title： Project Senior Assistant Professor / Project Assistant Professor / Project Lecturer
Homepage URL (2)： https://www.mip.tokyo-med.ac.jp/ , https://www.mip.tokyo-med.ac.jp/blank-12

Research field (1)： Biological, health, and medical informatics

Research keywords (2)： Metabolomics , Bioinformatics

Research theme for competitive and other funds (74)：

2022 - 2027 メタボローム解析を用いた肝転移切除後の再発予測バイオマーカーの探索
2022 - 2026 Development of educational evaluation system for trainees in minimally invasive surgery
2022 - 2026 Mathematical modeling of liver heterocell dynamics
2021 - 2026 Development of a new marker using metabolome in the diagnosis of advanced recurrent colorectal cancer
2020 - 2025 Study on clinical significance as the pancreatic cancer high-risk group by salivary metabolomics analysis for diabetes patients

2022 - 2025 Elucidation of pathological onset mechanism of psychiatric disorders by BDNF-mediated salivary gland-brain network

2022 - 2025 Development of new treatment for ocular malignant tumors by drug repositioning

2022 - 2025 産後うつ病を妊娠期に推測する指標開発と発症防止介入の検証

2021 - 2024 Elucidation of the mechanism of brain protection or brain damage by anesthetics

2021 - 2024 Metabolomics with alternative decision tree-based machine learning methods for the prediction of cdk 4/6 inhibitor efficacy

2021 - 2024 Elucidation of the Mechanism of COVID-19-Induced Taste Disorders: An Approach Based on ACE2-BDNF Linkage

2020 - 2023 Support of virtual human development project

2020 - 2023 Mathematical modeling of virtual human

2020 - 2023 Development of examination methods for oral hypofunction: A cohort study

2020 - 2023 人工知能とメタボローム解析を用いた肺癌の新規診断方法の開発

2018 - 2023 Study on the early diagnosis system for pancreatic cancer by the analysis of salivary metabolites

2021 - 2023 Visualization of decision making for on-line education in medical and nursing sciences.

2020 - 2023 Science for virtual human development: Organ(s)-on-a-chips reveal systemic metabolic networks

2020 - 2023 Proposal of a novel therapy for bullous keratopathy based on human-derived multiomics analysis

2020 - 2023 Elucidation of the mechanism of aspirin-induced intestinal mucosal injury focusing on the interaction between human microbiota and metabolites

2019 - 2022 Study on reduction of risk factors for life-style related diseases through activating brown and white adipose tissue by nutrition, exercise, and cold exposure

2019 - 2022 Development of salivary metabolomic biomarker for fatigue

2019 - 2022 Elucidation of pathological conditions of psychiatric disorders and development of clinical application methods using salivary metabolome mapping analysis

2019 - 2022 Salivaomics for oral cancer screening

2019 - 2022 唾液メタボローム解析を用いた放射線感受性予測法の確立

2019 - 2022 Diagnosis of kidney graft dysfunction using metabolome analusis

2019 - 2022 Metabolomic analysis of malignant ocular tumors-Creation of new biomarkers

2019 - 2022 間質応答を利用したホルモン受容体陽性乳がんの治療戦略の構築

2019 - 2022 遷延性意識障害患者への看護介入内容と効果の測定から客観的・定量的評価指標の確立

2018 - 2021 Establishing a method for predicting the effect of breast cancer chemotherapy using metabolome analysis

2018 - 2021 Development of breast cancer serum diagnostic method using NMR measurement based on a new concept

2018 - 2021 外科的がん切除後のデクスメデトミジンによる鎮静に不応な重症せん妄発症を予測するバイオマーカーの開発

2017 - 2020 Identification of factors related to penetrance and predictive model for ovarian cancer among BRCA1or BRCA2 mutation carriers

2017 - 2020 Improvement of physical function by water exercise and its effect on salivary aging markers

2017 - 2020 Establishment of screening methods for oral cancer/oral dysplasia with multi-omics based methods

2017 - 2020 唾液メタボローム解析によるがん口腔合併症のリスク因子解明、及び新たな治療法の確立

2017 - 2020 Comprehensive exploration of novel biomarkers for lung cancer and prognostic factors by thoracic lavage fluid metabolomic analysis

2017 - 2020 Effectiveness of using metabolomics in combination with MRI for evaluating liver metastasis from pancreatic cancer and biliary tract cancer

2017 - 2020 Examinations of anticancer drug sensitivity of pancreatic cancer using metabolomics from saliva and urine and plasma

2017 - 2020 Development of novel algorithm for quality control of metabolomics data

2017 - 2020 唾液代謝プロファイルを応用した精神疾患の病態解明および新規診断法の確立

2016 - 2020 Developing an drinking prevention education program for parents with pregnant and infant children

2016 - 2020 Usefulness of metabolome analysis for predicting the effect of chemotherapy for unresectable colorectal cancer

2016 - 2020 Prediction of radiosensitivity with salivary metabolomes

2015 - 2020 Achievement of highly accurate diagnosis of early pancreatic cancer in Japanese patients through a comprehensive/integrated approach

2017 - 2019 低酸素代謝リプログラミングを応用した培養口腔粘膜の品質向上

2016 - 2019 Evaluation of Nursing Interventions for Patients in Persistent Vegetative State using Minimally Invasive Assessments Methods

2016 - 2019 Identification of salivary biomarkers for oral cancer and pre-cancer screening with multi-omics data

2016 - 2019 Basic study of the possibility of newly synthesized 3-styrylchromone derivatives as therapeutic drugs for oral cancer

2016 - 2019 Development of tools to support clinical decision-making using integrated database of clinical information and basic research in patients with breast cancer

2016 - 2019 Evlutionary compuation method to determine essential brain function regions and metabolites

2016 - 2019 Establishment of liquid biopsy method for breast cancer diagnosis by salivary metabolomics

2015 - 2019 metabolomic profiling in patients with malignant pleural mesothelioma

2019 - 2019 ヒト生体試料中の微量代謝物の網羅的分析方法の確立

2016 - 2018 A non-invasive tool for detecting pancreatic tumor-bearing murine odor by C. elegans

2015 - 2018 Comprehensive analysis of salivary metabolites and establishment of new therapies in oral candidiasis

2014 - 2018 Search for salivary metabolome markers for cancer prediction and prognosis detection

2014 - 2018 Preparation of microRNA from saliva and detection of cancer and prediction of drug sensitivity using saliva

2014 - 2018 examination of the colorectal cancer marker using metabolomics from saliva

2014 - 2017 Mechanism of multidrug resistance caused after the treatment targeting CD44, and the strategy for overcoming the resistance in head and neck squamous cell carcinoma.

2013 - 2017 Identification of breast cancer-specific signatures in saliva metabolites using capillary electrophoresis mass spectrometry

2013 - 2017 Development of diagnostic method for acute rejection after kidney transplantation by blood / urinary metabolome analysis

2014 - 2015 Epidemiological study of prevention biomarker for mood and anxiety disorder by CE/MS based metabolimics

2013 - 2015 Development of salivary aging marker that reflects the collagen metabolites

2013 - 2015 Metabolome analysis of saliva with occlusal and masticatory stimulations

2012 - 2015 Search and Practical Use for Salivary Markers that Reflects the Severeness of Periodontal Diseases and Aging Markers

2012 - 2015 Cancer Detection using Metabolomic Analysis of Saliva

2012 - 2015 Prevention of non-communicable diseases and metabolic profiling in a population-based cohort study

2011 - 2015 Comprehensive analysis of salivary metabolites of periodontal diseases

2010 - 2015 Understanding cancer cell metabolism and biomarker discovery using metabolome analysis

2012 - 2014 Development of integrated database for metabolome data

2012 - 2014 Development of new diagnostic method by metabolome analysis using the saliva of patients with headache

2011 - 2014 Clarification about the antidepressant effect of salivary gland BDNF due to chewing

2011 - 2013 Establishment of saliva metabolome analysis using mice experimental cancer model

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Papers (198)：

Yuki Okinaka, Susumu Kageyama, Toshiyuki Goto, Masahiro Sugimoto, Atsumi Tomita, Yumi Aizawa, Kenichi Kobayashi, Akinori Wada, Akihiro Kawauchi, Yosky Kataoka. Metabolomic profiling of cancer-related fatigue involved in cachexia and chemotherapy. Scientific Reports. 2024. 14. 1
Benedikt Scheidecker, Stéphane Poulain, Masahiro Sugimoto, Taketomo Kido, Takumi Kawanishi, Atsushi Miyajima, Soo Hyeon Kim, Hiroshi Arakawa, Yukio Kato, Masaki Nishikawa, et al. Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro. Biofabrication. 2024. 16. 2. 025037-025037
Naohiro Kajiwara, Masatoshi Kakihana, Junichi Maeda, Miku Kaneko, Sana Ota, Ayame Enomoto, Norihiko Ikeda, Masahiro Sugimoto. Salivary metabolomic biomarkers for non-invasive lung cancer detection. Cancer science. 2024
Mina Nagao, Minoru Oshima, Hironobu Suto, Masahiro Sugimoto, Ayame Enomoto, Tomomasa Murakami, Ayaka Shimomura, Yukiko Wada, Hiroyuki Matsukawa, Yasuhisa Ando, et al. Serum Carbohydrate Antigen 19-9 and Metabolite Hypotaurine Are Predictive Markers for Early Recurrence of Pancreatic Ductal Adenocarcinoma. Pancreas. 2024. 53. 4. e301-e309
Aya Hirata, Sei Harada, Miho Iida, Ayako Kurihara, Kota Fukai, Kazuyo Kuwabara, Suzuka Kato, Minako Matsumoto, Mizuki Sata, Naoko Miyagawa, et al. Association of Nonalcoholic Fatty Liver Disease with Arterial Stiffness and its Metabolomic Profiling in Japanese Community-Dwellers. Journal of atherosclerosis and thrombosis. 2024

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MISC (171)：

Masahiro Sugimoto, Shigeo Ishikawa, Chitta Choudhary. Challenges Of Salivary Metabolomics For Diagnosis Of Metabolic Diseases. The British Journal of Translational Global Health. 2024
杉本昌弘. 唾液による代謝関連疾患の検査の開発. 日本歯科医師会雑誌. 2024. 76. 12. 19
Saliva reflects systemic metabolism. 2023. 58. 1. 1-6
Interviews with Outstanding Authors (2023). Annals of Breast Surgery. 2023
Masahiro Sugimoto. Computational Simulation of Tumor-Induced Angiogenesis. Methods in Molecular Biology. 2022. 275-283

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Patents (7)：

乳癌検出用唾液バイオマーカー、及び、これを用いた乳癌患者を健常者から識別するための方法
Salivary Metabolic Biomarkers for Human Oral Cancer Detection
Method of predicting traveling time of ionic compound by electrophoresis measuring (licensing-out to commercial company)
Diagnostic marker for liver diseases, its measurement method and instrument, and detection method of medical drugs
Prediction and training instrument and computer program.

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Books (12)：

キャピラリー電気泳動法・イオンクロマトグラフィーの分析テクニック
技術情報協会 2023 ISBN:9784861049934
「数理モデルによる仮想人体構築」『動物実験代替法とNew Approach Methodologiesの開発・利用動向』
シーエムシー出版 2023 ISBN:9784781317472
メタボローム解析によるがん検査の開発, Pharma Medica 38巻7号
メディカルレビュー社 2020
「唾液のメタボローム解析による膵がん検査の可能性」『早期発見・予防に向けた次世代がん検査技術の最前線』
シーエムシー出版株式会社 2019 ISBN:9784781314051
「どこまで使える? メタボローム解析」『実験医学』
羊土社 2018

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Lectures and oral presentations (78)：

唾液のメタボローム解析による分子マーカーの探索
(第67回日本唾液腺学会学術集会 2023)
ポリアミン研究の最前線
(第96回日本生化学会大会 2023)
肝臓の線維化における局在ごとに異なる代謝の変化
(第17回メタボロームシンポジウム 2023)
長期的な咀嚼による唾液代謝プロファイルの変動
(第17回メタボロームシンポジウム 2023)
南極における尿中代謝物プロファイルとうつ症状の関係
(2023)

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Education (3)：

- 2013 Kanagawa Dental College
2002 - 2005 Keio University
1998 - 2000 Waseda University Graduate School of Science and Engineering

Professional career (2)：

Ph.D. (Keio University)
Ph.D. (Kanagawa Dental University)

Work history (17)：

2020/10 - 現在 Doshisha University
2018 - 現在 University of Tsukuba
2017 - 現在 Tokyo Medical University
2016 - 現在京都大学大学院医学研究科非常勤講師
2016 - 現在 Meiji University School of Interdisciplinary Mathematical Sciences

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Committee career (2)：

2011 - 2014 メタボロームシンポジウム実行委員
2005 - 2007 日本システムバイオロジー研究会運営委員

Awards (3)：

2019/10/31 - 全国食品技術研究会事務局令和元年度全国食品技術研究会賞優秀賞山形県庄内産原料を使用した熟成生ハム開発と商品化
2013/07 - 国際Metabolomics学会 Metabolomics Society Best Paper
2011/10 - 山形県山形県科学技術奨励賞

Association Membership(s) (8)：

日本オミックス医学会 , Metabolomics Society , 歯科基礎医学会 , 日本膵癌学会 , 日本癌学会 , 日本分子生物学会 , 日本バイオインフォマティクス学会 , 日本乳癌学会

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