Rchr
J-GLOBAL ID：200901007966145369
Update date: Feb. 01, 2024
Tanaka Nobuyuki
タナカ ノブユキ | Tanaka Nobuyuki
Affiliation and department：
Job title：
Head
Other affiliations (1)：
Homepage URL (1)：
http://www.miyagi-pho.jp/mcc/htdocs/kenkyu/sensinchiryou.html
Research field (5)：
Immunology
, Virology
, Bacteriology
, Experimental pathology
, Medical biochemistry
Research keywords (7)：
サイトカイン
, 細胞外微粒子
, ウイルス感染
, がん
, 小胞輸送系
, Virology
, Immunology
Research theme for competitive and other funds (49)：
- 2022 - 2025 CMTM family proteins regulate PD-L1 exosome secretion and anti-tumor immunity
- 2022 - 2025 An engineered IL-15 reprogrammed for anti-tumor immunotherapy
- 2020 - 2023 Cytoskeleton-YAP axis regulates lung cancer resistanc: From mechanism to therapy
- 2019 - 2022 CMTMs regulate EGFR mutation positive NSCLC
- 2018 - 2021 S100A10 on Cancer Stem Cell and Microenvironment: Towards therapeutic application
- 2016 - 2019 Tumor associated Neutrophils control NSCLC-Immune interface
- 2016 - 2018 CSPG4 is a putative cancer stem cell marker and potential therapeutic target of HNSCC
- 2015 - 2018 Role of the alternation of steroid hormone level in the response and resistance to endocrine therapy for breast cancer
- 2015 - 2018 Immune escape mediated by the EGFR-derived signal: From Mechanism to Therapy
- 2015 - 2018 Actin cytoskeleton control by a HNSCC stem cell marker CD271
- 2015 - 2017 Validation of CD271 as a Therapeutic Target of Squamous Cell Carcinoma
- 2015 - 2017 Analysis of CD271-positive NSCLC as a potential therapeutic target
- 2015 - 2017 Survival mechanism of CD271-positive HNSCC and itstherapeutic intervention
- 2012 - 2016 Roles of ESCRT in Oncogenesis
- 2013 - 2015 CD271+ cancer stem cells: a novel therapeutic target of head and neck squamous cell carcinoma
- 2012 - 2015 Regulatory mechanism for intracellar traficking of the membrane-bound NEU3 sialidase
- 2012 - 2015 Combining Afatinib and Cetuximab synergistically increases their cytotoxicity for EGFR T790M-harboring cells
- 2012 - 2015 Identification of a Cancer stem cell marker and therapeutic target by xenotlansplantation methods
- 2011 - 2013 Analysis of Head and Neck Cancer malignancy related to EMT and Cancer Stem Cells
- 2009 - 2011 Mechanism of SARS coronavirus infection and proliferation
- 2009 - 2010 Role of ESCRT proteins in the malignant phenotype control of Head and Neck Cancer Cells
- 2008 - 2009 ESCRT小胞輸送複合体によるがん制御機構の解析
- 2008 - 2008 小胞輸送分子Hrsを介する細胞老化とがん細胞悪性形質の制御
- 2007 - 2008 ESCRT小胞輸送蛋白複合体によるレトロウイルス感染増殖制御
- 2007 - 2008 脱ユビキチン化酵素AMSH、AMSH-LPによるタンパク質分解機構の解明
- 2007 - 2008 Decrease of type II pneumocyte function by aging in the process oflung fibrosis : multi-aspect evaluation of STAM1 gene
- 2007 - 2008 Mechanism of virus infection and proliferation by an deubiquitination enzyme, AMSH
- 2005 - 2006 新規脱ユビキチン化酵素AMSHノックアウトによるユビキチン病発症機構の研究
- 2005 - 2006 Virus proliferation mechanism by the monoubiquitin-dependent vesicular transport complex
- 2002 - 2006 Signal transducing pathways in immune cells and immunological disorders caused by their dysfunctions
- 2006 - 細胞内小胞輸送系によるウイルス感染制御
- 2005 - 2005 新規小胞輸送蛋白質複合体Hrs・STAMsによるがん抑制機構
- 2004 - 2005 遺伝子ノックアウトを用いた新規クラスE分子群による小胞輸送の研究
- 2004 - 2004 新規小胞輸送蛋白質複合体Hrs・STAMsによるがん抑制機構
- 2004 - 2004 新規クラスE小胞輸送蛋白質による抗原提示機能制御
- 2004 - 2004 小胞輸送に関わる新規VHSドメイン蛋白分子群によるウイルス増殖制御
- 2003 - 2004 IMMUNE REGULATION BY THE P38 MAP KINASE PATHWAYS
- 2002 - 2003 Control of immunological tolerance and its breakdown by cytokine
- 1998 - 1999 Establishment of Model Mice of Rheumatoid Arthritis by using nonstructural protein 1 (NS1) of parvovirus B19
- 1998 - 1998 サイトカイン受容体を介する新たな増殖シグナル伝達経路“Jak-STAM"
- 1997 - 1998 A novel signal transducing adaptor molecule "STAM" involved in TCR-mediated signal transduction
- 1996 - 1996 新規IL-2依存性チロシンリン酸化蛋白分子(pp70)の機能的役割
- 1996 - 1996 T細胞シグナル伝達機構におけるItkチロシンキナーゼの役割
- 1994 - 輸送系による免疫制御
- 輸送系による発がんと悪性化の解析
- Development of Cancer Immunotherapy
- Cancer Stem Cells
- Analysis of T-cell and DC interaction
- crest
Show all
Papers (59)：
-
Kana Watanabe, Ryota Saito, Eisaku Miyauchi, Hiromi Nagashima, Atsushi Nakamura, Shunichi Sugawara, Nobuyuki Tanaka, Hiroshi Terasaki, Tatsuro Fukuhara, Makoto Maemondo. Monitoring of Plasma EGFR Mutations during Osimertinib Treatment for NSCLC Patients with Acquired T790M Mutation. Cancers. 2023. 15. 17
-
Jessica A Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juárez, Helen Khuu, Katrin Soldau, Donald P Pizzo, Jin Wang, Adela Malik, Timothy F Shay, Erin E Sullivan, et al. Diminished neuronal ESCRT-0 function exacerbates AMPA receptor derangement and accelerates prion-induced neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023
-
Masahiko Miyamoto, Toshiki Himeda, Kazuki Ishihara, Takako Okuwa, Daiki Kobayashi, Masaaki Nameta, Yu Karasawa, Benyapa Chunhaphinyokul, Yutaka Yoshida, Nobuyuki Tanaka, et al. Theilovirus 3C Protease Cleaves the C-Terminal Domain of the Innate Immune RNA Sensor, Melanoma Differentiation-Associated Gene 5, and Impairs Double-Stranded RNA-Mediated IFN Response. The Journal of Immunology. 2022
-
前田 昂樹, 小山 昂志, 木村 咲伽, 長島 隆一, 三浦 滉矢, 荒川 将志, 岡村 真弥, 蝦名 博貴, 田中 伸幸, 森田 英嗣. 人工被膜ナノ粒子による樹状細胞への免疫原性ペプチド抗原送達方法の開発. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3T11a-04
-
Yuji Takeda, Yuta Kurota, Tomoyuki Kato, Hiromi Ito, Akemi Araki, Hidetoshi Nara, Shinichi Saitoh, Nobuyuki Tanaka, Norihiko Tsuchiya, Hironobu Asao. GPI-80 Augments NF-κB Activation in Tumor Cells. International journal of molecular sciences. 2021. 22. 21
ｍore...
MISC (54)：
-
長島 隆一, 田中 伸幸. 【最新リンパ球研究情報】Nrf2によるアレルギー性気道炎症の制御. 臨床免疫・アレルギー科. 2019. 72. 5. 486-494
-
横山 美沙, 渋谷 莉恵, 坂本 良美, 田沼 延公, 望月 麻衣, 中村 真央, 玉井 恵一, 山口 壹範, 田中 伸幸, 菅村 和夫, et al. ピルビン酸キナーゼM2(PKM2)と膵癌細胞増殖. 膵臓. 2016. 31. 3. 547-547
-
玉井 恵一, 中村 真央, 小鎌 直子, 渋谷 莉恵, 望月 麻衣, 山口 壹範, 菅村 和夫, 田中 伸幸, 佐藤 賢一. 胆管癌においてBEX2はがん幹細胞の機能を制御する. 日本消化器病学会雑誌. 2016. 113. 臨増総会. A268-A268
-
Ryuji Oshima, Takafumi Hasegawa, Keiichi Tamai, Atsushi Takeda, Nobuyuki Tanaka, Masashi Aoki. Forebrain-specific knockout of ESCRT-0/Hrs disrupts protein quality control and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways. MOVEMENT DISORDERS. 2016. 31. S60-S60
-
望月 麻衣, 玉井 圭一, 山口 壹範, 今井 隆之, 佐藤 賢一, 松浦 一登, 小鎌 直子, 中村 真央, 本橋 ほづみ, 菅村 和夫, et al. 頭頸部癌におけるCD271の機能性. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P1058]-[1P1058]
ｍore...
Patents (1)：
-
IL-2 MUTANT PROTEIN AND MEDICINE CONTAINING SAME
Professional career (1)：
Committee career (1)：
Association Membership(s) (5)：
AACR
, 日本細菌学会
, THE JAPANESE CANCER ASSOCIATION
, 日本内科学会
, JAPANESE SOCIETY FOR IMMUNOLOGY (JSI)
