SHIRAKABE KYOKO

シラカベキョウコ | SHIRAKABE KYOKO

Affiliation and department：
Homepage URL (1)： http://www.ritsumei.ac.jp/~kshira/index.html

Research field (7)： Immunology , Pathobiochemistry , Medical biochemistry , Cell biology , Functional biochemistry , Molecular biology , Tumor biology

Research keywords (8)： Inflammation , Signal transduction , Cancer , Alternative splicing , Ectodomain shedding , ADAM family metalloproteases , Membrane proteins , Membrane proteins, ADAM family metalloproteases, Ectodomain shedding, Alternative splicing, Cancer, Signal transduction, Inflammation

Research theme for competitive and other funds (14)：

2018 - 2021 Molecular mechanism and functional significance of the regulation of ectodomain shedding by alternative splicing
2018 - 2020 選択的スプライシングによるシェディング制御の分子機序と機能的意義
2017 - 接着分子ALCAMのシェディングによる発がん制御
2013 - 2015 蛍光シグナルを用いた膜タンパク質シェディングのイメージング
2010 - 2015 プロテオミクス技術によるシェディングの生理機能と制御機構の解明

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Papers (1)：

白壁恭子. プロテオーム解析から明らかになったシェディングの役割と制御機構、化学と生物. 2019. 57. 1. 15-20

MISC (14)：

Iwagishi R, Tanaka R, Seto M, Takagi T, Norioka N, Ueyama T, Kawamura T, Takagi J, Ogawa Y, Shirakabe K. Negatively charged amino acids in the stalk region of membrane proteins reduce ectodomain shedding. J Biol Chem. 2020. in press
Hanafusa H., Yagi T., Ikeda H., Hisamoto N., Nishioka T., Kaibuchi K., Shirakabe K. and Matsumoto K. LRRK1 phosphorylation of Rab7 at S72 links trafficking of EGFR-containing endosomes to its effector RILP. J Cell Sci. 2019. 132. 11
Tsumagari K.*, Shirakabe K., Ogura M., Sato F., Ishihama Y. and Sehara- Fujisawa A. Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation. Genes Cells. 2017. 22. 2. 237-244
Shirakabe K., Omura T., Shibagaki Y., Mihara E., Homma K., Kato Y., Yoshimura A., Murakami Y., Takagi J., Hattori S. and Ogawa Y. Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation. Sci Rep. 2017. 7. 46174
Shirakabe K., Shibagaki Y., Yoshimura A., Koyasu S. and Hattori S. A proteomic approach for the elucidation of stimulus- and substrate-specificity of ectodomain shedding. J. Proteomics. 2014. 98. 233-243

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Books (1)：

プロテオーム解析から明らかになったシェディングの役割と制御機構
国際文献社 2019

Lectures and oral presentations (14)：

膜タンパク質のシェディングを介した亜鉛シグナル制御機構の解明
(第42回日本分子生物学会年会 2019)
選択的スプライシングによるCADM1のシェディング感受性制御が細胞の分化に及ぼす影響
(第42回日本分子生物学会年会 2019)
ゲノム編集技術を用いたSIRPαのスプライシングバリアントの機能解析
(第42回日本分子生物学会年会 2019)
LRRK1はRab7 Ser-72をリン酸化し、エフェクター分子RILPによるEGFR含有エンドソームの輸送を促進する
(第42回日本分子生物学会年会 2019)
Susceptibility to ectodomain shedding of membrane proteins is determined by alternative splicing
(11th General Meeting of the International Proteolysis Society 2019)

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Education (5)：

- 1997 Kyoto University Graduate School of Science
- 1997 Kyoto University Graduate School of Science Department of Biophysics
- 1994 The University of Tokyo Graduate School of Science
- 1994 The University of Tokyo Graduate School of Science Department of Biochemistry and Biophysics
- 1992 The University of Tokyo Faculty of Science Department of Biochemistry

Professional career (1)：

Ph.D. (Science) (Kyoto University)

Work history (20)：

2018/04 - Ritsumeikan University Department of Biomedical Sciences, College of Llife Science
2015/04/01 - 2018/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
2015/04 - 2018/03 東京医科歯科大学大学院医歯学総合研究科ジョイントリサーチ講座助教授・准教授
2010/05/01 - 2015/03/31 Keio University School of Medicine
2010/05 - 2015/03 慶應義塾大学医学部非常勤講師

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Association Membership(s) (5)：

Japan Society for Proteases in Pathophysiology , Japan Human Proteome Organisation , Japan Society of Cell Biology , The Molecular Biology Society of Japan , The Japanese Biochemical Society

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