Research theme for competitive and other funds (37)：
2023 - 2026 アセチルコリン/ドパミン神経回路を標的としたうつ病の新規治療法の探索
2023 - 2026 抗うつ薬作用増強に必要なドパミン・ノルアドレナリン神経回路機構の解明
2023 - 2026 Development of treatments for post traumatic stress disorder related to surgery and intensive care.
2022 - 2025 統合失調症のドーパミン仮説を実現するモデルマウスの神経学的病態機構の解明
2022 - 2025 炎症性疾患によるうつ病発症機序の解明:脳内ドパミンシグナルに着目して
2022 - 2025 Elucidating the mechanisms by which female mice identify attractive male mice.
2022 - 2025 Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
2019 - 2022 Involvement of dopamine and noradrenaline signaling mechanisms in depression and schizophrenia.
2019 - 2022 Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system
2018 - 2021 Investigation of the interaction between dopamine and noradrenaline signaling in the hippocampus to develop novel treatment of depression
2018 - 2021 Novel approaches for treatment of addiction after social defeat stress
2016 - 2020 Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal
2016 - 2019 Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders
2016 - 2019 Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders
2015 - 2018 Does oxdative stress reaction in nucleus accumbes exacerbate cocaine addiction after social defeat stress?
2016 - 2018 治療抵抗性統合失調症の診断法及び治療法の開発
2014 - 2017 Role of chondroitin sulfate-E in the modulation of neuronal morphology
2016 - 2017 ドパミン神経系を標的とした精神神経疾患治療薬の創薬基盤研究
2012 - 2015 Functional role of the N-terminal domain of DFosB in response to stress and drugs of abuse.
2012 - 2012 ptimization of FIB/SEM techniques ? the novel ultrastructureeanalysis by combination of serial thin ablation and block surface material contrastobservation - for biomedical mesoscale three dimentional structural analysis.
2007 - 2012 精神疾患モデルマウスの脳のシグナル伝達の生化学的解析
2010 - 2011 遺伝子発現を制御するドーパミンシグナル:DARPP-32を介する調節機構
2009 - 2010 ドーパミンシグナルの多様性を探る:神経サブタイプ個別解析
2008 - 2009 神経再生療法開発のための基礎的研究
2006 - 2007 線条体領域ドーパミン情報伝達マップ:病態モデルへの展開
2004 - 2005 Elucidating the structure and function of chondrotin sulfate proteoglycan in differentitation, development and regeneration of dopaminergic neurons
2004 - 2005 線条体領域ドーパミン情報伝達マップ
2003 - 2004 Role of GABA_B receptors in dopamine/DARPP-32 signaling
2002 - 2004 神経発達を促進する分子機構の研究
2001 - 2004 Neurochemical studies on pathophysiology and treatment of attention deficit hyperactivity disorder
OHNISHI Yoshinori, KAWAHARA Yukie, KISHI Yuki, OHNISHI Yoko, NISHI Akinori. What methods are physiologically or pharmacologically effective for attracting female mice?. 日本薬理学会年会要旨集(Web). 2022. 95th
大西克典, 河原幸恵, 大西陽子, 西昭徳. Is male mouse attractiveness inherited?. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳. Differential role of dopamine in the PFC and NAc in cocaine-associated reward memory and behavior. 日本薬理学雑誌. 2021. 156. Supplement
The role of phosphodiesterases in disorders of motivated behavior, in Cyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery
Wiley & Sons, Inc. 2014
Education (2)：
1989 - 1993 Karolinska Institutet
1979 - 1985 Miyazaki Medical College
Professional career (2)：
博士(医学) (久留米大学)
Ph.D. (カロリンスカ研究所)
Work history (7)：
2015 - 現在 Kurume University Kurume University
2006 - 現在 Kurume University School of Medicine
1997 - 2020 ロックフェラー大学 客員研究員
2004 - 2006 Kurume University School of Medicine
1998 - 2004 Kurume University School of Medicine
1985 - 1998 Kurume University School of Medicine
1995 - 1997 ロックフェラー大学 ポスドク
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Association Membership(s) (6)：
JAPAN BRAIN SCIENCE SOCIETY
, SfN
, THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
, JAPAN PEDIATRIC SOCIETY
, THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
, THE JAPANESE PHARMACOLOGICAL SOCIETY
