Rchr

J-GLOBAL ID：200901008177740879 Update date: Apr. 20, 2024

Komuro Issei

コムロイッセイ | Komuro Issei

Affiliation and department：
Job title： vice president

Research field (1)： Cardiology

Research keywords (1)：心不全

Research theme for competitive and other funds (63)：

2021 - 2026 DNA damage and senescence in cardiomyocytes for the development of heart failure
2021 - 2022 非分裂細胞である心筋細胞のDNA損傷と老化による心不全発症機序の解明
2017 - 2020 Cardiomyocyte heterogeneity in heart failure
2016 - 2019 アジア諸国における歯周病と生活習慣病の関連を解明する調査研究
2014 - 2017 Epigenome analysis in cardiomyocyte differentiation and failure

2014 - 2017 Nationwide database platform of cardiovascular diseases to measure quality indicator and develop predicting model

2013 - 2017 Analysis of the origin of newly formed cardiomyocytes and their growth and mitotic factor by cardiac progenitor cell scaffold transplantation model.

2014 - 2016 Elucidation of functional role of gut microbiota in heart failure

2014 - 2016 Identification and mechanical analysis of the functional lncRNA in pro-inflammatory macrophages

2013 - 2016 Angiopoietin-1-mediated vascular development and maturation in the developing heart

2013 - 2015 The novel therapeutic strategy for pulmonary hypertension targeting inflammation amplification loop mediated by IL-6

2012 - 2014 ブタ心筋梗塞、心不全モデルでの腎動脈周囲高周波焼灼術による心機能改善効果の検討

2012 - 2014 Elucidation of molecular bases for phenotypical modification of dilated cardiomyopathy by environmental factors

2011 - 2014 Elucidation of inflammatory network underlying the pathogenesis of atrial fibrillation

2009 - 2014 Role of Wnt signaling in cardiomyocyte differentiation and its implication for the treatment of heart diseases

2010 - 2013 Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiber

2012 - 2012 The role of sarcomere-specific isoform of docking protein Gab1in heart failure

2008 - 2010 Molecular analysis of angiontensin II receptor inactivation by inverse agonists

2008 - 2010 Analysis of rennin/histamine secreted from cardiac mast cells during heart failure

2009 - 2009 Wntシグナルによる心筋分化ならびに心臓疾患発症機序の解明

2006 - 2007 造血系サイトカイン受容体を標的とした新規の心不全治療薬の開発

2006 - 2007 Molecular mechanisms of cardiomyocyte differentiation and their therapeutic implications

2006 - 2007 Molecular mechanisms of heart failure and their therapeutic implications revealed by inducible transgenic mice

2005 - 2006 Establishment of clonal cardiac stem cells and identification of molecular mechanisms of cardiac

2005 - 2006 Anti-senescence therapy for the treatment of age-associated cardiovascular and metabolic diseases

2005 - 2006 Functional analysis of ErbB receptor signaling in the hearts

2005 - 2006 Inverse agonist activity of angiotensin II type 1 receptor blockers

2005 - 2006 心筋/非心筋融合細胞を用いた心筋誘導因子の探究

2005 - 2006 FRETを用いたアンジオテンシンII受容体シグナル可視化の試み

2004 - 2005 誘導型心不全モデルマウスを用いた、心不全の病態解明と新たな心不全治療法の開発

2000 - 2005 Molecular Mechanisms of Heat Failure and Its Novel Therapeutic Strategies

2003 - 2004 Molecular Mechanisms of Cardiomyocyte Differentiation

2003 - 2004 Isolation and characterization of skeletal muscle-derived cardiac progenitor cells for cardiac regeneration therapy

2002 - 2004 Establishment of mouse model and treatment for vascular aging

2000 - 2004 細胞分化による心不全の遺伝子治療

2002 - 2003 ROLES OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ IN CARDIOVASCULAR DISEASE

2002 - 2003 STABILIZATION OF CORONARY PLAQUES BY MEDICINES EVALUATED USING INTRAVASCULAR ULTRASOUND RADIOFREQUENCY SIGNAL ANALYSIS.

2002 - 2003 Analysis of Wnt signaling pathway during cardiomyocyte differentiation

2002 - 2003 心臓の発生分化における分子メカニズムの解明と心筋細胞分化誘導への応用

2000 - 2002 心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立

2000 - 2002 Isolation and analysis of molecules which associate with Csx

2000 - 2002 Gene therapy and cell transplantation for heart failure.

2000 - 2002 The role of sodium calcium exchanger (NCX)on cardiac function.

2000 - 2002 Analysis for Molecular Mechanism of Cardiomyocyte Differentiation by Using a Cell Line Which Efficiently Differentiates into Cardiomyocytes

2001 - 2001 未分化細胞からの心筋細胞の分離

2001 - 2001 「脳の形成」と「生活習慣病予防」に運動が必要なわけを探る-個体の運動解析モデルと細胞による運動解析モデルの開発-

2000 - 2000 腹腔内異物周囲に形成される肉芽組織を用いた自己血管再生法の開発

2000 - 2000 心筋細胞への新しい遺伝子導入法

1997 - 1999 心血管系の発生分化とその分子機構の解析

1996 - 1998 The elucidation of the roles of transcription factor in heart diseases

1997 - 1997 心筋特異的ホメオボックス遺伝子の機能解析と会合する分子の単離

1997 - 1997 心筋細胞におけるアポトーシス誘導の分子機序及びその防御

1995 - 1997 心筋梗塞に伴う心機能不全の発生機序の解明と新しい治療法の開発

1995 - 1996 Elucidation of molecular mechanism of mechanical stretch-induced cardiac hypertrophy

1994 - 1996 心筋細胞の発生分化とその制御機構

1994 - 1996 Characterrization of cardiac specific specific homebox gene

1994 - 1996 Establishment of cardiac myocyte cell line

1994 - 1994 機械的伸展負荷によって生じる心肥大の発生機序の解明とそれに基づいた治療薬の開発

1991 - 1992 Intracellular Signaling of Stretch Mediated Myocyte Growth

1988 - 1989 モノクローナル抗体を用いた心筋梗塞画像診断法の開発-臨床への応用と再灌流での実験的検討-

1987 - 1989 Molecular analysis of the pathophysiology of heart disease

1987 - 1987 ヒト心筋ミオシン重鎖・軽鎖の遺伝子構造及び発現調節機構に関する研究

1986 - 1986 ヒト心筋ミオシン軽鎖遺伝子の構造とその発現

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Papers (1,401)：

Keita Negishi, Kenichi Aizawa, Takayuki Shindo, Toru Suzuki, Takayuki Sakurai, Yuichiro Saito, Takuya Miyakawa, Masaru Tanokura, Yosky Kataoka, Mitsuyo Maeda, et al. Author Correction: An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility. Scientific reports. 2024. 14. 1. 7874-7874
Toshiyuki Ko, Yuta Suzuki, Hidehiro Kaneko, Takahiro Jimba, Jin Komuro, Akira Okada, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, et al. Applying the HARMS2-AF Risk Score for Japanese population: An analysis of a nationwide epidemiological dataset. European journal of preventive cardiology. 2024
Toshiyuki Ko, Issei Komuro. A Valuable Genetically Engineered Nonhuman Primate Model of Dilated Cardiomyopathy. JACC. Basic to translational science. 2024. 9. 3. 396-398
Satoshi Ishii, Masaru Hatano, Shun Minatsuki, Kazutoshi Hirose, Akihito Saito, Hiroki Yagi, Mai Shimbo, Katsura Soma, Chihiro Konoeda, Masaaki Sato, et al. Comprehensive Risk Assessment in Patients With Pulmonary Arterial Hypertension Referred for Lung Transplantation. Circulation journal : official journal of the Japanese Circulation Society. 2024
Masaki Tsuji, Takahiro Kurihara, Yoshitaka Isotani, Chie Bujo, Junichi Ishida, Eisuke Amiya, Masaru Hatano, Asako Shimada, Hiroko Imai, Mitsutoshi Kimura, et al. Right heart reserve function assessed with fluid loading predicts late right heart failure after left ventricular assist device implantation. The Canadian journal of cardiology. 2024

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MISC (2,126)：

Mai Shimbo, Eisuke Amiya, Issei Komuro. Telemonitoring during Exercise Training in Cardiac Telerehabilitation: A Review. Reviews in Cardiovascular Medicine. 2023. 24. 4
蛭間貴司, 中山敦子, 七里守, 伊東春樹, 小室一成, 磯部光章. Comprehensive Cardiac Rehabilitation Following Myocardial Infarction Improves Clinical Outcomes Regardless of Exercise Capacity. 日本循環器学会学術集会抄録集. 2023. 87回. OJ46-9
戴哲皓, 候聡志, 野村征太郎, 藤田寛奈, 濱野桃子, 山西芳裕, 尾上健児, 小室一成. 心筋組織におけるDNA損傷は原疾患によらず左室駆出率の低下した心不全の治療反応及び予後を予測する. 日本内科学会雑誌. 2023. 112. 臨増. 144-144
小室一成, 蔵野信, 岩佐健史, 山賀亮之介. 【脂質異常症だれを・どこまで・どのように】脂質異常症だれを・どこまで・どのように治療するか. Medical Practice. 2023. 40. 1. 6-18
清原悠嵩, 小寺聡, 仁宮洸太, 澤野晋之介, 勝然進, 篠原宏樹, 安東治郎, 赤澤宏, 小室一成. 患者情報から冠攣縮性狭心症を判別する自然言語処理人工知能モデル. 心臓. 2022. 54. 11. 1235-1242

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Books (72)：

東大医学部の学生とつくった循環器病ロジカルテキスト
南山堂 2023 ISBN:9784525249519
今日の治療指針 : 私はこう治療している
医学書院 2023 ISBN:9784260050340
診療ガイドラインUP-TO-DATE : 日常診療に活かす
メディカルレビュー社 2022 ISBN:9784779225802
今日の治療指針 : 私はこう治療している
医学書院 2022 ISBN:9784260047777
今日の治療指針 : 私はこう治療している
医学書院 2022 ISBN:9784260047760

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Education (1)：

1976 - 1982 The University of Tokyo Faculty of Medicine School of Medicine

Professional career (1)：

PhD (The University of Tokyo)

Work history (10)：

2023/06 - 現在 The University of Tokyo
2023/04 - 現在 International University of Health and Welfare
2012 - 2023/03 The University of Tokyo
2009 - 2012 Osaka University
2001/04 - 2009 Chiba University

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Awards (21)：

2022/08 - Gold Medal
2022/04 - 文部科学大臣表彰科学技術賞
2021 - Huaxia Medial Science and Technology Award Crertificate China International Exchange and Promotive Association for Medical and Health Care (CPAM)
2012/11 - 第16回日本心血管内分泌代謝学会高峰譲吉賞
2012/11 - 日本医師会医学賞

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Association Membership(s) (15)：

日本医学会連合 , アジア太平洋心臓学会 , 日本心血管内分泌代謝学会 , International Society for Heart Research , American Heart Association , 日本心不全学会 , 日本循環器協会 , 日本腫瘍循環器学会 , 日本循環器学会 , 日本内科学会 , 日本分子生物医学会 , 日本高血圧学会 , 日本臨床分子医学会 , 日本脈管学会 , 日本心臓病学会

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