HIDEAKI TSUGE

ツゲヒデアキ | HIDEAKI TSUGE

Affiliation and department：
Homepage URL (1)： http://www.cc.kyoto-su.ac.jp/~tsuge/tsugelab/index.html

Research field (4)： Medical biochemistry , Bacteriology , Structural biochemistry , Biophysics

Research keywords (8)：細菌、毒素、ウィルスの細胞侵入機構 , カテプシン阻害剤 , ディフィシル菌二成分毒素CDT , ウェルシュ菌イオタ毒素 , クライオ電子顕微鏡単粒子解析 , X線結晶構造解析 , タンパク質膜透過機構 , ADPリボシル化

Research theme for competitive and other funds (21)：

2021 - 2024 Dynamic Structural Analysis of Protein Translocation Across Membrane by Cryo-EM
2018 - 2021 Structural and Functional Study of Binary Toxin Translocon by Cryo-EM and X-ray Crystallography
2015 - 2018 Rho GTPase Recognition Mechanism of ADP-ribosylating C3 exoenzyme
2014 - 2017 Rational design of DyP type peroxidase based on the topology
2014 - 2016 Structure-activity relationship of carcinogenic factor, Tip-alpha, from Helicobacter pylori

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Papers (105)：

Akihiro Kawamoto, Tomohito Yamada, Toru Yoshida, Yusui Sato, Takayuki Kato, Hideaki Tsuge. Cryo-EM structures of the translocational binary toxin complex CDTa-bound CDTb-pore from Clostridioides difficile. Nature Communications. 2022. 13. 1. 6119-6119
Toru Yoshida, Hideaki Tsuge. Common Mechanism for Target Specificity of Protein- and DNA-Targeting ADP-Ribosyltransferases. Toxins. 2021. 13. 1. 40-40
Tomohito Yamada, Hideaki Tsuge. Preparation of Clostridium perfringens binary iota-toxin pore complex for structural analysis using cryo-EM. Methods in enzymology. 2021. 649. 125-148
Hideaki Tsuge. A myelin sheath protein forming its lattice. Journal of Biological Chemistry. 2020. 295. 26. 8706-8707
Tomohito Yamada, Toru Yoshida, Akihiro Kawamoto, Kaoru Mitsuoka, Kenji Iwasaki, Hideaki Tsuge. Cryo-EM structures reveal translocational unfolding in the clostridial binary iota toxin complex. Nature Structural & Molecular Biology. 2020. 27. 3. 288-296

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MISC (10)：

吉田徹, 津下英明. ADPリボシル化酵素がタンパク質やDNAを特異的に修飾する仕組み. 生化学. 2021. 93. 6. 862-866
M. Nagahama, M. Oda, H. Tsuge, K. Kobayashi. Enteric toxins of Clostridium perfringens: Beta-toxin, tpeL, epsilon-toxin and iota-toxin. Molecular Medical Microbiology (Second edition). 2015. 2. 997-1013
Modification reaction mechanism based on the complex structure of enzyme-substrate protein at pre- and post-reaction states : The reaction mechanism of iota toxin from Clostridium perfringens. 2014. 27. 5. 233-240
Hideaki Tsuge, Toshiharu Tsurumura, Hiroko Utsunomiya, Daisuke Kise, Takashi Kuzuhara, Tatsuro Watanabe, Hirota Fujiki, Masami Suganuma. Structural basis for the helicobacter pylori-carcinogenic TNF(-inducing protein. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2011. 67. C475-C475
渡邉達郎, 津下英明, 藤井温子, 高橋淳, 藤木博太, 菅沼雅美. Helicobacter pyloriの遺伝子を用いた研究:病原因子から分子疫学まで Helicobacter pyloriのTipαによるヌクレオリンを介した発がん促進機構. Helicobacter Research. 2010. 14. 4

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Lectures and oral presentations (57)：

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Education (2)：

Professional career (1)：

Work history (8)：

2018/04 - 現在 Kyoto Sangyo University
2016/04 - 現在 Kyoto Sangyo University Institute for Protein Dynamics
2010/04 - 現在 Kyoto Sangyo University Faculty of Life Sciences, Department of Bioresource and Environmental Sciences
2002/04 - 2010/03 徳島文理大学健康科学研究所兼人間生活学部(旧家政学部) 教授
2003/04 - 2009/03 The University of Tokushima

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Committee career (9)：

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Awards (1)：

Association Membership(s) (9)：

American Society for Biochemistry and Molecular Biology , 日本細菌学会 , 日本蛋白質科学会 , 日本生物物理学会 , 日本生化学会 , 日本結晶学会 , 日本ビタミン学会 , 毒素シンポジウム , 日本分子生物学会

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