Sheikh Mohammad Fazle Akbar

Akbar Sheikh Mohammad | Sheikh Mohammad Fazle Akbar

Affiliation and department：
Job title： Researcher

Research field (5)： Laboratory animal science , Applied microbiology , Immunology , Experimental pathology , Gastroenterology

Research keywords (8)： Re-purposing immune modulators for pre-exposure and post-exposer prophylaxes and treatment of SARS-CoV-2 and COVID-19 , Accomplishment of phase/II/II clinical trials with immune therapeutic agent for chronic hepatitis B , Immune therapy for chronic hepatitis B and hepatocellular carcinoma , Preparation of antigen-presenting dendritic cells and use for treatment , Development of immune therapy for chronic hepatitis B virus infection in mouse model , Elucidation role of antigen-presenting cells in autoimmunity , Role of antigen-presenting dendritic cells in multiple pathologies , Mechanism of pathogenesis underlying chronic infection and cancer

Research theme for competitive and other funds (8)：

2005 - 2006 Development of immune therapy against primary biliary cirrhosis using tolerogenic dendritic cells
2002 - 2003 Development of therapy for chronic hepatitis C using interferon-producing dendritic cells
持続感染における抗原提示樹状細胞
Antigen presenting Cells and neonatal tolerance
B型慢性肝疾患におけるワクチン治療

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Papers (197)：

Mamun Al Mahtab, Musarrat Mahtab, Md Abdur Rahim, Sheikh Mohammad Fazle Akbar, Sakirul Khan, Takaaki Yahiro, Shohael Mahmud Arafat, Mohammad Abdus Sattar Sarker, Provat Kumar Podder, Mohammad Shawkat Hossain, et al. Recent Dengue Infection in Bangladesh: A Seasonal Endemic Progressing to Year-long Serious Health Concern. Euroasian journal of hepato-gastroenterology. 2023. 13. 2. 145-151
Kana Shiraishi, Osamu Yoshida, Yusuke Imai, Sheikh Mohammad Fazle Akbar, Takahiro Sanada, Michinori Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Masashi Hirooka, et al. Intranasal HBsAg/HBcAg-Containing Vaccine Induces Neutralizing Anti-HBs Production in Hepatitis B Vaccine Non-Responders. Vaccines. 2023. 11. 9
Sheikh Mohammad Fazle Akbar, Mamun Al Mahtab, Osamu Yoshida, Julio Aguilar, Guillen Nieto Gerardo, Yoichi Hiasa. Development of Therapy Based on the Exploration of Biological Events Underlying the Pathogenetic Mechanisms of Chronic Hepatitis B Infection. Biomedicines. 2023. 11. 7
Mamun Al-Mahtab, Sheikh Mohammad Fazle Akbar, Osamu Yoshida, Julio Cesar Aguilar, Gerardo Guillen, Yoichi Hiasa. Antiviral Response across Genotypes after Treatment of Chronic Hepatitis B Patients with the Therapeutic Vaccine NASVAC or Pegylated Interferon. Vaccines. 2023. 11. 5
Sheikh Mohammad Fazle Akbar, Mamun Al Mahtab, Sakirul Khan. Cellular and Molecular Mechanisms of Pathogenic and Protective Immune Responses to SARS-CoV-2 and Implications of COVID-19 Vaccines. Vaccines. 2023. 11. 3. 615-615

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MISC (43)：

S. M. F. Akbar, S. Chen, M. Al-Mahtab, T. Miyake, Y. Hiasa. MYELOID-DERIVED SUPPRESSOR CELLS AND DENDRITIC CELLS FOR IMPAIRED RESPONSE TO VACCINE IN MICE WITH NONALCOHOLIC FATTY LIVER DISEASE. JOURNAL OF HEPATOLOGY. 2014. 60. 1. S143-S144
Chen Shiyi, Sheikh Mohammad Fazle Akbar, 阿部雅則, 日浅陽一, 恩地森一. B型肝炎 HBVキャリアマウスモデルにおける肝Myeloid-derived suppressor cell(MDSC)の機能. 肝臓. 2012. 53. Suppl.1. A329-A329
Shiyi Chen, Sheikh Mohammad Fazle Akbar, Masanori Abe, Yoichi Hiasa, Morikazu Onji. HEPATIC MYELOID-DERIVED SUPPRESSOR CELLS CONTROLLING INTRAHEPATIC IMMUNITY IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS. HEPATOLOGY. 2011. 54. 1110A-1110A
S. M. F. Akbar, S. Furukawa, N. Horiike, M. Abe, Y. Hiasa, M. Onji. Safety and immunogenicity of hepatitis B surface antigen-pulsed dendritic cells in patients with chronic hepatitis B. JOURNAL OF VIRAL HEPATITIS. 2011. 18. 6. 408-414
Chen Shiyi, Fazle Akbar, 阿部雅則, 日浅陽一, 恩地森一. 肝臓におけるMyeloid-derived suppressor cell(MDSC)の機能解析. 肝臓. 2011. 52. Suppl.1. A280-A280

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Patents (3)：

Hepatitis B Vaccine Nasal Administration System
Nasal hepatitis B vaccine composition and its production method
2006-512091

Books (8)：

Practical Hepato-Gastroenterology Prescriber
Macmilan Medical Communications 2016
Companion to Hepatitis Management
Macmilan Medical Communications 2016
Hepatitis Management Update
Macmilan Medical Communications 2015
Textbook of Hepatogastroenterology
Jaypee Brothers Medical Publishers, India 2015
Comprehensive Text Book of Hepatitis B
Jaypee Brothers Medical Publishers, India 2010

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Lectures and oral presentations (91)：

Therapeutic vaccination and innovative strategies to treat CHB
(30th Annual Meeting of INASL - 2022, Delhi, India 2022)
NASVAC - immune thrapy for chronic hepatitis B
(18 th National Hepato Gastroenterology Congress on May 12-15,2022 Noah’s Ark Hotel and Congress Center, T.R.N.C. 2022)
Immune Therapy for CHB: Hope and Hype after 8 years follow up
(2022)
Re-purposing HBV therapy for COVID-19
(EGACON 2021, 18th Annual Conference of Euroasian Gastroenterological Association, Dhaka, Bangladesh 2021)
Immune Therapy: Can it be the Game Changer for Hepatitis B
(SAASL 2021 8th Annual Conference of South Asian Association for the Study of the Liver 2021)

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Works (2)：

Phase I/II/and III clinical trials in Patients with chronic hepatitis
2009 - 現在
KIT development for Dendritic Cells
2005 - 2006

Education (4)：

- 1993 Ehime University Graduate School, Division of Medical Sciences
1987 - 1988 Osaka University of Foreign Language
1980 - 1981 Institute of Post Graduate Medicine and Research
1980 - 1980 Rajshahi Medical College

Professional career (1)：

Ph. D. in Medical Sciences

Work history (13)：

2020/04 - 現在 Ehime University Graduate School of Medicine Department of Gastroenterology and Metabology
2018/06 - 2020/03 Ehime University Graduate School of Medicine Department of Analytical Pathology Proteo-Science Center
2018/04 - 2018/05 Ehime University Graduate School of Medicine
2008/04 - 2018/03 Toshiba General Hospital Department of Medical Sciences
1996/11 - 2008/03 Ehime University Graduate School of medicine Department of Gastroenterology and Metabology

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Committee career (1)：

2018 - 現在 Miyakawa Memorial Research Foundation Councilor

Awards (5)：

2021/08 - Indian National Association for the Study of the Liver Dr. S R Naik Memorial Oration Dr. S R Naik Memorial Oration
2019/04 - Cuban Academy of Science National Award, Cuban Academy of Science
2017/07 - KALINGA GASTROENTEROLOGY FOUNDATION. Blumberg Oration
2016/04 - Euroasian Gastroenterological Association Order of Merit
2004 - Kyoto Liver Forum

Association Membership(s) (9)：

Japan Dendritic Cell Society , The European Association for the Study of the Liver , The Americal Association for the Study of Liver Diseases , Japanese Society for Immunology , The Japanese Society of Gastroenterology , Japan Dendritic Cell Society , Japanese Society for Immunology , The Japanese Society of Gastroenterology , The Japan Society of Hepatology

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