Rchr
J-GLOBAL ID：200901009296595077   Update date: Apr. 19, 2024

Kishimoto Tadamitsu

キシモト タダミツ | Kishimoto Tadamitsu
Affiliation and department：
Osaka University

About Osaka University


Research field  (2)： Internal medicine - General ,  Immunology
Research keywords  (5)： Clinical Immunology and Allergy ,  Immnology ,  アレルギー内科学 ,  免疫 ,  免疫学
Research theme for competitive and other funds  (31)：
  • 2015 - 2018 MAPKシグナルに関連したArid5aタンパク質分解機構の解明
  • 2014 - 2016 The pathogenic role of Arid5a in infection and autoimmunity.
  • 2013 - 2016 免疫細胞および自己免疫疾患のIL-6 mRNA調節におけるArid5aの役割
  • 1997 - 2003 感染症と免疫病の分子生物学と医学
  • 1999 - 2002 Regulatory mechanism of signal transduction in the immune system.
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Papers (232)：
  • Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto, et al. Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2402226121
  • Sujin Kang, Shinya Onishi, Zhenzhen Ling, Hitomi Inoue, Yingying Zhang, Hao Chang, Hui Zhao, Tong Wang, Daisuke Okuzaki, Hiroshi Matsuura, et al. Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 2. e2315898120
  • Masashi Narazaki, Tadamitsu Kishimoto. Current status and prospects of IL-6-targeting therapy. Expert Review of Clinical Pharmacology. 2022. 15. 5. 575-592
  • Siddhika Pareek, Xenia Sanchenkova, Taiki Sakaguchi, Mari Murakami, Ryu Okumura, Hisako Kayama, Saya Kawauchi, Daisuke Motooka, Shota Nakamura, Daisuke Okuzaki, et al. Epithelial miR-215 negatively modulates Th17-dominant inflammation by inhibiting CXCL12 production in the small intestine. Genes to cells : devoted to molecular & cellular mechanisms. 2022. 27. 4. 243-253
  • Kishan Kumar Nyati, Shigeru Hashimoto, Shailendra Kumar Singh, Murat Tekguc, Hozaifa Metwally, Yu-Chen Liu, Daisuke Okuzaki, Yohannes Gemechu, Sujin Kang, Tadamitsu Kishimoto. The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway. Cancer Letters. 2021. 520. 295-306
ｍore...
MISC (197)：
  • Sujin Kang, Toshio Tanaka, Hitomi Inoue, Chikako Ono, Shoji Hashimoto, Yoshiyuki Kioi, Hisatake Matsumoto, Hiroshi Matsuura, Tsunehiro Matsubara, Kentaro Shimizu, et al. COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 21
  • Hozaifa Metwally, Toshio Tanaka, Songling Li, Gyanu Parajuli, Sujin Kang, Hamza Hanieh, Shigeru Hashimoto, Jaya P Chalise, Yohannes Gemechu, Daron M Standley, et al. Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production. Science signaling. 2020. 13. 624
  • Hozaifa Metwally, Toshio Tanaka, Tadamitsu Kishimoto. Arid5a expression is induced through MYD88-independent pathway in response to TLR4 stimulation in IFNy-sensitized human macrophages.'. JOURNAL OF IMMUNOLOGY. 2017. 198. 1
  • Masashi Narazaki, Toshio Tanaka, Tadamitsu Kishimoto. The role and therapeutic targeting of IL-6 in rheumatoid arthritis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2017. 13. 6. 535-551
  • Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto. Immunotherapeutic implications of IL-6 blockade for cytokine storm. IMMUNOTHERAPY. 2016. 8. 8. 959-970
ｍore...
Books (2)：
  • B lymphocyte activation, proliferation and immunoglobulin secretion.
    Fundamental Immunology, Raven Press, New York 1989
  • B lymphocyte activation, proliferation and immunoglobulin secretion.
    Fundamental Immunology, Raven Press, New York 1989
Professional career (1)：
  • MD, PhD (Osaka University)
Committee career (24)：
  • 2002 - 日本医学会 副会長
  • 2002 - The Japanese Association of Medical Sciences vice-president
  • 1997 - 1998 日本アレルギー学会 会長
  • 1997 - 1998 Japanese Society of Allergology president
  • 1986 - 1997 Immunology Board, US-Japan Medical Cooperative Program chairman
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Awards (26)：
  • 2003 - ロベルト・コッホゴールドメダル
  • 2003 - Robert Koch Gold Medal
  • 1998 - 文化勲章
  • 1998 - The Order of Culture from Emperor
  • 1996 - アベリー・ランドスタイナー賞(The Avery-Landsteiner Prize from the German Immunology Society)
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Association Membership(s) (26)：
日本医学会 ,  米国血液学会 ,  米国国立科学アカデミー医学研究所 ,  日本臨床免疫学会 ,  日本アレルギー学会 ,  日本学士院 ,  国際サイトカイン学会 ,  米国免疫学会 ,  米国国立科学アカデミー ,  国際免疫薬理学会 ,  日本免疫学会 ,  国際免疫学会連合 ,  The Japanese Association of Medical Sciences ,  American Society of Hematology ,  USA ,  The Institute of Medicine of the National Academy of Science ,  Japanese Society of Clinical Immunology ,  Japanese Society of Allergology ,  The Japan Academy ,  International Cytokine Society ,  The American Association of Immunologists ,  The US National Academy of Science ,  International Society of Immunopharmacology ,  Japanese Society of Immunology ,  US-Japan Medical Cooperative Program ,  Immunology Board
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