Mizuno Toshihisa

ミズノトシヒサ | Mizuno Toshihisa

Affiliation and department：
Job title： Associate Professor

Research field (1)： Biochemistry

Research keywords (4)： Peptide Engineering , Nano-materials , Protein Engineering , Biofunctional chemistry

Research theme for competitive and other funds (18)：

2020 - 2023 外来蛋白質の細胞膜透過キャリアとしてのアルキル鎖を複数含むカチオン性ペプチド開発
2020 - 2021 ペプチドジェミニ界面活性剤ベースの蛋白質医薬品導入試薬の開発
2020 - 2021 不織布型の新規酵素固定化担体の開発
2019 - 2020 ペプチドジェミニ界面活性剤ベースの蛋白質医薬品導入試薬の開発
2017 - 2020 Development and application of novel bio-inks able to use for 3D-molding of biomacromolecules

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Papers (68)：

Kousuke Takahashi, Yasumichi Inoue, Shigeaki Hida, Naoki Umezawa, Isamu Akiba, Mitsuo Umetsu, Toshihisa Mizuno. Target-selective cytosolic delivery of cargo proteins using the VHH-presented OLE-ZIP capsules. ChemRxiv. 2024
Kousuke Takahashi, Taiki Nishiyama, Naoki Umezawa, Yasumichi Inoue, Isamu Akiba, Takehisa Dewa, Atsushi Ikeda, Toshihisa Mizuno. Delivery of external proteins into the cytoplasm using protein capsules modified with IgG on the surface, created from the amphiphilic two helix-bundle protein OLE-ZIP. Chemical communications (Cambridge, England). 2024
Yurino Sunakawa, Mai Kondo, Yasushi Yamamoto, Tomohiko Inomata, Yasumichi Inoue, Daisuke Mori, Toshihisa Mizuno. Design of Cell-Adhesive Shellac Derivatives and Endowment of Photoswitchable Cell-Adhesion Properties. ACS applied bio materials. 2023. 6. 12. 5493-5501
Yuna Kato, Shuichi Iwata, Yusuke Nasu, Akiko Obata, Kenji Nagata, Robert E. Campbell, Toshihisa Mizuno. Construction of the lactate-sensing fibremats by confining sensor fluorescent protein of lactate inside nanofibers of the poly(HPMA/DAMA)/ADH-nylon 6 core-shell fibremat. RSC Advances. 2023. 13. 42. 29584-29593
Taira Ishiguro, Akiko Obata, Kenji Nagata, Toshihiro Kasuga, Toshihisa Mizuno. Core-shell fibremats comprising a poly(AM/DAAM)/ADH nanofibre core and nylon6 shell layer are an attractive immobilization platform for constructing immobilised enzymes. RSC advances. 2022. 12. 54. 34931-34940

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MISC (3)：

Lectures and oral presentations (183)：

Construction of Protein-loadable Protein Cages Using the Hybrid Proteins of the Oleosin Hydrophobic Domain and Hydrophilic Dimeric Coiled-coil
(ISNM2021 2021)
セルロースをシェル成分に持つ酵素固定化不織布の作製と酵素活性評価
(第52回中部化学関係学協会支部連合秋季大会(静岡) 2021)
細胞膜透過PG-surfactantを用いた外来蛋白質の細胞内輸送
(第52回中部化学関係学協会支部連合秋季大会(静岡) 2021)
TGFβシグナル伝達経路阻害ペプチドの設計と作製
(第52回中部化学関係学協会支部連合秋季大会(静岡) 2021)
異種細胞表面でのトランススプライシング反応における細胞表面からのリンカー長さの影響評価
(第52回中部化学関係学協会支部連合秋季大会(静岡) 2021)

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Education (3)：

Professional career (4)：

Awards (1)：

Association Membership(s) (4)：

高分子学会 , 生体機能関連化学部会 , 日本化学会 , 繊維学会

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