Hirai Toyohiro

Affiliation and department：

Research field (1)： Respiratory medicine

Research theme for competitive and other funds (8)：

2020 - 2023 Cross-sectional and prospective study with metabolome analysis to detect pathophysiology about the relationship between deterioration in lung function and sleep disordered breathing
2015 - 2018 Application of iPS cell technology to lung regeneration and development of bioresource for elucidating the mechanisms of lung diseases
2010 - 2015 Researches using iPS cells on intractable respiratory diseases to elucidate their pathogenesis and develop novel therapy.
2010 - 2012 New system for quantitative analysis of chest CT images in pulmonary diseases
2008 - 2010 Analysis of Intra-cellular signaling pathway and gene network in acute lung injury as for therapeutic strategy.

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Papers (564)：

Yuko Ohnishi, Atsushi Masui, Takahiro Suezawa, Ryuta Mikawa, Toyohiro Hirai, Masatoshi Hagiwara, Shimpei Gotoh. Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells. Stem cell reports. 2024. 19. 4. 529-544
Issei Oi, Isao Ito, Naoya Tanabe, Satoshi Konishi, Yumiko Ibi, Yu Hidaka, Nobuyoshi Hamao, Masahiro Shirata, Kensuke Nishioka, Seiichiro Imai, et al. Investigation of predictors for in-hospital death or long-term hospitalization in community-acquired pneumonia with risk factors for aspiration. European Clinical Respiratory Journal. 2024. 11. 1
Nobuyoshi Hamao, Isao Ito, Issei Oi, Masahiro Shirata, Kensuke Nishioka, Yasuyuki Hayashi, Seiichiro Imai, Toyohiro Hirai. Clinical phenotypes of nontuberculous mycobacterial disease by cluster analysis based on pulmonary function. Respiratory Medicine. 2024. 225
Yusuke Hayashi, Naoya Tanabe, Hisako Matsumoto, Kaoruko Shimizu, Ryo Sakamoto, Tsuyoshi Oguma, Hironobu Sunadome, Atsuyasu Sato, Susumu Sato, Toyohiro Hirai. Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma. Allergology international : official journal of the Japanese Society of Allergology. 2024
Daisuke Natori, Hiroaki Ozasa, Yusuke Shima, Chisaki Mizumoto, Keiichiro Suminaga, Takashi Nomizo, Hitomi Ajimizu, Hironori Yoshida, Toyohiro Hirai. Successful treatment of lung cancer coexisting with B-cell lymphoma with pembrolizumab following rituximab-included chemotherapy: A case report. Molecular and Clinical Oncology. 2024. 20. 4

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MISC (218)：

白石祐介, 田辺直也, 前谷知毅, 張怡, 坂本亮, 鍛冶静雄, 池添浩平, 谷澤公伸, 小熊毅, 室繁郎, et al. Quantitative CT analyses of Interstitial Lung Abnormality in patients with COPD. 日本呼吸器学会誌(Web). 2023. 12
Masatoshi Yamazoe, Hiroaki Ozasa, Tatsuya Ogimoto, Kazutaka Hosoya, Hitomi Ajimizu, Tomoko Yamamoto, Takahiro Tsuji, Ryo Itotani, Yuichi Sakamori, Takashi Nomizo, et al. TEAD single nucleotide polymorphism affects PFS in EGFR-mutation positive lung cancer patients treated with EGFR TKIs. CANCER SCIENCE. 2022. 113. 1014-1014
Masatoshi Yamazoe, Hiroaki Ozasa, Tetsuya Ohgimoto, Kazutaka Hosoya, Hitomi Ajimizu, Tomoko Funazo, Yuto Yasuda, Takahiro Tsuji, Hironori Yoshida, Ryo Itotani, et al. Activation of YAP1 confers ROS1 inhibitor resistance in ROS1-rearranged lung cancer. CANCER RESEARCH. 2021. 81. 13
Masatoshi Yamazoe, Hiroaki Ozasa, Tatsuya Ogimoto, Kazutaka Hosoya, Hitomi Ajimizu, Yuto Yasuda, Tomoko Funazo, Takahiro Tsuji, Hironori Yoshida, Yuichi Sakamori, et al. Activation of YAP1 confers ROS1 inhibitor resistance in ROS1-rearranged lung cancer. CANCER SCIENCE. 2021. 112. 890-890
村瀬公彦, 陳和夫, 赤星俊樹, 津田徹, 大井元晴, 外山善朗, 成井浩司, 富田康弘, 大平徹郎, 葛西隆敏, et al. The effect of telemonitoring of weight on its reduction in sleep apnea patients: Multicenter randomized trial. 日本呼吸器学会誌(Web). 2021. 10

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