Research field (6):
Chemical biology
, Pharmaceuticals - chemistry and drug development
, Bioorganic chemistry
, Synthetic organic chemistry
, Molecular biochemistry
, Applied biofunctional and bioprocess engineering
Research theme for competitive and other funds (14):
2021 - 2024 血管新生因子をターゲットとした癌細胞特異的蛍光プローブの開発
2018 - 2022 Cancer cell-specific imaging with the fluorescent probe responding by thymidine phosphorylase
2012 - 2015 Synthesis of the variety nucleostide probes produced by synchronization of the biocatalyst and the palladium catalyst
2014 - 2015 人工核酸を用いた細胞内レドックス環境のセンシングとイメージング
2012 - 2013 核酸代謝酵素を利用した安定同位体導入ヌクレオシドの効率的合成
2004 - 核酸転移酵素の機能解明と阻害剤の開発
1999 - 2000 金属イオンにより誘起される人工DNAの自発的集合化
非天然核酸合成
脂質を用いたペプチに分子の機能化
非天然アミノ酸を利用した金属イオンの集積化
金属配位結合で二重鎖を形成する人工DNA
Functinalization of the peptids by lipid modifications
The accumulation of the metal ion by mean of artificial amino acids
Metal-anisted formation of artificial nucleic acids
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Papers (34):
Genki SHIMANE, Nanae Terado, Akihiko HATANO. Chemoenzymatic synthesis of unnatural nucleoside with stable isotopes. 3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development, 2023. 2023. P28
Rai Hamano, Akihiko Hatano, Riki Matsuzaka. Synthesis of pentostatin precursor with pyrimidine nucleoside phosphorylase. 3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development, 2023. 2023. P24
Akihiko Hatano, Riki Matsuzaka, Genki Shimane, Hiroyuki Wakana, Kou Suzuki, Chisato Nishioka, Aoi Kojima, Masatoshi Kidowaki. Introduction of pseudo-base benzimidazole derivatives into nucleosides via base exchange by a nucleoside metabolic enzyme. Bioorganic & Medicinal Chemistry. 2023. 91. 117411-117411
Saki Endo, Mahiro Sarai, Akihiko Hatano, Kenichi Niikura. Supramolecular Conjugation between 18-Crown 6-Ether and Tannic Acid with Unique pH Responsiveness. Chemistry Letters. 2023
Rei HAMANO, Koichi OTSUKIi, Akihiko HATANO. Effects of Functional Groups Recognition of Nucleoside Structure for Phosphorolysis with Pyrimidine Nucleoside Phosphorylase PyNP. SEATUC 2023. 2023