Takahashi Tsuyoshi

タカハシツヨシ | Takahashi Tsuyoshi

Affiliation and department：
Research theme for competitive and other funds (16)：

2022 - 2025 Development of rapid screening method to discover peptides capable of binding to target proteins using split intein
2023 - 2024 感染能を保持するウイルスを特異的に検出するためのインテイン連鎖反応(ICR)の開発
2018 - 2022 Comprehensive screening of drug-binding proteins using a detection method for their interactions based on chemical reactions between reactive peptide tags
2015 - 2019 Construction of novel screening method using enzyme reconstitution and creation of bicyclic functional D-peptides
2012 - 2014 Construction of Detection System for Ligand Screening in Solution Using Peptide Generation based on Molecular Interactions

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Papers (51)：

Tsuyoshi Takahashi, Tatsuya Uchibayashi, Nozomi Ishii, Ichiro Matsuo, Yukiko Yoshida, Tadashi Suzuki. Luminescence detection of peptide:N-glycanase activity using engineered split inteins. Chemical communications (Cambridge, England). 2022. 58. 95. 13282-13285
Tsuyoshi Takahashi, Hiroaki Hagiwara. Detecting ligand-protein interactions inside cells using reactive peptide tags and split luciferase. Chemical Communications. 2021. 57. 9906-9909
Misaki Kawase, Meiko Fujioka, Tsuyoshi Takahashi. Activation of Protease and Luciferase Using Engineered Nostoc Punctiforme PCC73102 DnaE Intein with Altered Split Position. ChemBioChem. 2021. 22. 3. 577-584
Yusuke Maeda, Toshiki Sawada, Tsuyoshi Takahashi, Hideya Yuasa, Hisakazu Mihara. Affinity Control of Monosaccharide Conjugated Peptides against Lectins with a Set of Amino Acid Substitutions on α-Helical Structures. Bioconjugate Chemistry. 2020. 31. 11. 2533-2540
Tsuyoshi Takahashi. Generation of Active Protease Depending on Peptide-Protein Interactions Using Interaction-Dependent Native Chemical Ligation and Protein Trans-Splicing. Bulletin of the Chemical Society of Japan. 2019. 92. 10. 1767-1772

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MISC (13)：

OKURA Hiromichi, TAKAHASHI Tsuyoshi, MIHARA Hisakazu. Selection of Fluorescein-Binding De Novo Proteins with α3β3 Structures. 2011. 2010. 158-158
KIKUCHI Kazuya, USUI Kenji, TOMIZAKI Kin-ya, TAKAHASHI Tsuyoshi, MIHARA Hisakazu. Designed Peptide Libraries for Protein and Cell analyses. 2011. 2010. 21-21
古木隆生, 清水天平, 黄川田隆洋, 奥田隆, 高橋剛, 三原久和, 櫻井実. モデルペプチドを用いたLEA(Late Embryogenesis Abundant)タンパク質の分子構造とガラス化に与える塩濃縮効果の検討. 熱測定討論会講演要旨集. 2010. 46th
古木隆生, 清水天平, 黄川田隆洋, 奥田隆, 高橋剛, 三原久和, 櫻井実. モデルペプチドを用いたLEA(Late Embryogenesis Abundant)タンパク質の分子構造とガラス化の研究. 熱測定討論会講演要旨集. 2009. 45th
菊池卓哉, 臼井健二, 高橋剛, 三原久和. 種々の細胞系を用いた新規αヘリックスペプチドの細胞導入活性スクリーニング. 日本化学会バイオテクノロジー部会シンポジウム講演要旨集. 2009. 12th

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Patents (5)：

Books (3)：

Lectures and oral presentations (32)：

分割インテインとカナマイシンキナーゼの再構成を利用した新規リガンド探索法の構築
(日本化学会第103春季年会 2023)
糖ペプチドの合成と細胞質ペプチド:N-グリカナーゼおよびエンド-β-N-アセチルグルコサミニダーゼによる反応性の検討
(日本化学会第103春季年会 2023)
分割インテインを用いた細胞質ペプチド:N-グリカナーゼ活性の細胞内発光検出
(日本化学会第103春季年会 2023)
Selection of peptides capable of binding to MDM2 using an engineered split intein
(第59回ペプチド討論会 2022)
Construction of a detection method for peptide: N-glycanase activity using engineered split inteins
(第59回ペプチド討論会 2022)

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Education (1)：

Professional career (1)：

Work history (2)：

Gunma University
Former Institution / Organization Tokyo Institute of Technology Graduate School of Biosciences and Biotechnology Department of Bioengineering Assistant Professor

Awards (2)：

Association Membership(s) (4)：

日本ペプチド学会 , 日本化学会 , Japanese Peptide Society , The Chemical Sociey of Japan

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