Yamada Keiichi

ヤマダケイイチ | Yamada Keiichi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://peptide-chem.chem-bio.st.gunma-u.ac.jp/

Research field (5)： Pharmaceuticals - chemistry and drug development , Chemical biology , Radiology , Synthetic organic chemistry , Molecular biochemistry

Research keywords (6)：ペプチド化学 , 抗菌ペプチド , radioactive compounds , bioactive compounds , non-coded amino acids , peptides

Research theme for competitive and other funds (16)：

2021 - 2024 Development of radioactive agent for targeted alpha therapy of triple negative breast cancer
2020 - 2023 アルファ線内用療法用アスタチン211の安全で簡便な標識法の開発
2018 - 2021 環状ペプチドライブラリーを用いた放射性薬剤探索研究の新機軸
2017 - 2020 Evaluation of silicon-astatine exchange reaction by kinetics approach and its applications to the development of alpha-emitting therapeutic agents
2015 - 2019 PET薬剤を指向した放射性臭素標識ペプチドの実用的合成法の開発

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Papers (43)：

Mami Yasukagawa, Keiichi Yamada, Seiji Tobita, Toshitada Yoshihara. Ratiometric oxygen probes with a cell-penetrating peptide for imaging oxygen levels in living cells. Journal of Photochemistry and Photobiology A: Chemistry. 2019. 383. 111983
Shigeki Watanabe, Mohammad Anwar-UI Azim, Ichiro Nishinaka, Ichiro Sasaki, Yasuhiro Ohshima, Keiichi Yamada, Noriko S. Ishioka. A convenient and reproducible method for the synthesis of asatinated 4-[211At]astato-L-phenylalanine via electrophilic desilylation. Organic & Biomolecular Chemistry. 2019. 17. 1. 165-171
Eisuke Horigome, Michiru Fujieda, Tadashi Handa, Ayaka Katayama, Masashi Ito, Ami Ichihara, Daiki Tanaka, Navchaa Gombodorj, Shinji Yoshiyama, Arito Yamane, et al. Mutant TP53 modulates metastasis of triple negative breast cancer through adenosine A2b receptor signaling. Oncotarget. 2018. 9. 77. 34554--34566
Ryosuke Shintoku, Yuta Takigawa, Keiichi Yamada, Chisato Kubota, Yuhei Yoshimoto, Toshiyuki Takeuchi, Ichiro Koshiishi, Seiji Torii. Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3. CANCER SCIENCE. 2017. 108. 11. 2187-2194
山田圭一. PET薬剤を指向した放射性ハロゲン標識化合物の開発:現状と課題. BIO Clinica. 2017. 32. 7. 66-71

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MISC (144)：

木本侑大, 奥浩之, 山田圭一, 矢野和彦, 狩野繁之. マラリア原虫エノラーゼにおけるプラスミノーゲン結合部位の探索. 日本化学会春季年会講演予稿集(CD-ROM). 2016. 96th
I. Sasaki, S. Watanabe, Y. Oshima, Y. Sugo, K. Yamada, H. Hanaoka, N. S. Ishioka. Medical application of radiohalogenated peptides: Synthesis and in vitro evaluation of F(p-131I)KCCYSL for targeting HER2. Peptide Science 2015. 2016. 2015. 243-246
K. Yamada, S. Watanabe, S. Watanabe, T. Takahashi, T. Moriguchi, H. Oku, N. S. Ishioka, K. Shinozuka. Synthesis and properties of silylated phenylalanine derivatives. Peptide Science 2015. 2016. 2015. 93-94
Shigeki Watanabe, Keiichi Yamada, Saki Watanabe, Hiroyuki Oku, Tomohisa Moriguch, Kazuo Shinozuka, Noriko S. Ishioka. Synthesis of radiobrominated amino acid derivatives via silicon-bromine exchange reaction. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2015. 58. S256-S256
I. Sasaki, H. Hanaoka, K. Yamada, S. Watanabe, Y. Sugo, Y. Oshima, H. Suzuki, N. S. Ishioka. Exploring of peptides with affinity to HER2 from random peptide libraries using radioisotope: Random hexapeptide libraries with fixed amino acid sequence at 1 and 2 positions. Peptide Science 2014. 2015. 2014. 257-260

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Patents (20)：

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Lectures and oral presentations (146)：

Synthesis of head-to-tail cyclic peptides using Bpoc-chemistry
(59th Japanese Peptide Symposium 2022)
Studies on Cell Penetrating Peptides Containing 4-Guanidino-L-Proline Residues
(56th Japanese Peptide Symposium 2019)
有機ケイ素前駆体を用いたアスタチン標識アミノ酸の合成
(第58回日本核医学会学術総会 2018)
ケイ素ーアスタチン交換反応を用いたアスタチン標識アミノ酸誘導体の合成
(第62回放射化学討論会 2018)
ケイ素-ハロゲン交換反応を用いた放射性臭素標識化合物合成に関する基礎的検討
(第2回日本核医学会分科会放射薬品科学研究会/第18回放射性医薬品・画像診断薬研究会 2018)

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Professional career (1)：

Dr.Eng. (Nagoya Institute of Technology)

Work history (7)：

2015/01 - 現在 Gunma University Division of Molecular Science Associate Professor
2014/04 - 現在 National Institute of Advanced Industrial Science and Technology
2014/04 - 2014/12 Gunma University Graduate School of Science and Technology, Department of Materials and Bioscience
2013/04 - 2014/03 Gunma University
2007/04 - 2013/03 Gunma University

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Association Membership(s) (5)：

日本分子イメージング学会 , 有機合成化学協会 , 日本ペプチド学会 , American Chemical Society , 日本化学会

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