Doi Mitsunobu

ドイミツノブ | Doi Mitsunobu

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://msc.oups.ac.jp

Research field (3)： Pharmaceuticals - analytical and physicochemistry , Biophysics , Structural biochemistry

Research keywords (7)：ペプチド化学 , 分子設計 , X線結晶構造 , 生体関連物質の構造解析 , Molecular design , X-Ray crystallography , Structural analysis of bio-organic compounds

Research theme for competitive and other funds (10)：

2017 - 2019 Development of cell penetrating peptide utilizing the charactaristic of disubstituted amino acid
2008 - 2010 Development of dosage form using elastin fragments by incorporation of β-amino acids
2007 - 2009 環状ジ置換アミノ酸配座固定ペプチドライブラリーによる免疫制御分子の探索
1995 - 1997 Interaction between heteromolecules-Structural study and application of PNA-
1994 - 1994 グラミシジンSの会合状態と細胞膜への作用機構

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Papers (127)：

Takahito Ito, Hidetomo Yokoo, Takuma Kato, Mitsunobu Doi, Yosuke Demizu. Sculpting Secondary Structure of a Cyclic Peptide: Conformational Analysis of a Cyclic Hexapeptide Containing a Combination of l-Leu, d-Leu, and Aib Residues. ACS Omega. 2023
Akiko Asano, Mizuki Sakata, Takuma Kato, Mitsunobu Doi. Puckering of 4-Fluoro-L-proline Isomers and 4,4-Difluoro-L-proline Influencing Conformation of Ornithine-free Gramicidin S. Chemistry Letters. 2023. 52. 4. 246-248
Takuma Kato, Hiroaki Numa, Mihoko Nakamachi, Akiko Asano, Mitsunobu Doi. Effects of Substituting Disubstituted Amino Acids into the Amphipathic Cell Penetrating Peptide Pep-1. Chemical and Pharmaceutical Bulletin. 2022. 70. 11. 812-817
Atsushi Ueda, Yui Makura, Sana Kakazu, Takuma Kato, Tomohiro Umeno, Kazuhiro Hirayama, Mitsunobu Doi, Makoto Oba, Masakazu Tanaka. E-Selective Ring-Closing Metathesis in α-Helical Stapled Peptides Using Carbocyclic α,α-Disubstituted α-Amino Acids. Organic Letters. 2022. 24. 4. 1049-1054
Akiko Asano, Chisato Minami, Shiori Matsuoka, Takuma Kato, Mitsunobu Doi. An Ornithine-Free Gramicidin S Analogue Using Norleucine, Cyclo(Val-Nle-Leu-D-Phe-Pro)₂, Forms Helically Aligned β-Sheets. Chemical and Pharmaceutical Bulletin. 2021. 69. 11. 1097-1103

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MISC (358)：

加藤巧馬, 出水庸介, 田中正一, 浅野晶子, 土井光暢. Evaluation of the effect of the type of disubstituted amino acids on the peptide secondary structure in a heteropeptide of leucine and disubstituted amino acids. 日本薬学会年会要旨集(Web). 2023. 143rd
佐藤和樹, 梅野智大, 上田篤志, 土井光暢, 加藤巧馬, 田中正一. N末をチオウレアで修飾したヘリカルペプチド触媒による不斉マイケル付加反応. 創薬懇話会講演要旨集. 2021. 2021
真倉唯, 上田篤志, 梅野智大, 加藤巧馬, 平山和浩, 土井光暢, 大庭誠, 田中正一. E-selective ring-closing metathesis for i, i+4 stapled peptides. 日本薬学会年会要旨集(Web). 2021. 141st
佐藤和樹, 梅野智大, 上田篤志, 土井光暢, 加藤巧馬, 田中正一. Asymmetric 1,4-addition reactions using N-terminal thiourea-modified helical peptide-catalysts. 日本薬学会年会要旨集(Web). 2021. 141st
加藤巧馬, 中町瑞穂子, 浅野晶子, 土井光暢. Development of amphipathic cell penetrating peptide based on Pep-1 sequence. 第57回ペプチド討論会 (オンライン). 2020. P-085

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Education (2)：

- 1983 Osaka University Graduate School, Division of Pharmaceutical Sciences
- 1981 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Science

Professional career (2)：

Association Membership(s) (4)：

日本分析化学会 , 日本ペプチド学会 , 日本結晶学会 , 日本薬学会

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