Rchr
J-GLOBAL ID：200901011102908660   Update date: Apr. 21, 2024

Imaoka Tatsuhiko

Imaoka Tatsuhiko | Imaoka Tatsuhiko
Affiliation and department：
National Institutes for Quantum Science and Technology Department of Radiation Effects Research, Institute for Radiological Science

About National Institutes for Quantum Science and Technology Department of Radiation Effects Research, Institute for Radiological Science


Job title： Group Leader
Homepage URL  (2)： https://www.nirs.qst.go.jp/usr/radeff/ ,  https://www.nirs.qst.go.jp/usr/radeff/en/
Research field  (7)： Hygiene and public health (laboratory) ,  Radiology ,  Tumor biology ,  Nanobioscience ,  Environmental effects of radiation ,  Developmental biology ,  Morphology, anatomy
Research keywords  (7)： biology for radiological protection ,  application of quantum technologies to biomedical research ,  radiation carcinogenesis ,  breast cancer and mammary gland biology ,  tissue stem cells and cell-of-origin of cancer ,  mutational signatures in the cancer genome ,  development and homeostasis
Research theme for competitive and other funds  (20)：
  • 2020 - 2030 量子生命技術の創製と医学・生命科学の革新
  • 2021 - 2025 Genetic susceptibility to radiation-induced breast cancer: establishment of an animal model for developing prevention strategy
  • 2019 - 2024 放射線が細胞競合に及ぼす影響をラット乳腺培養系で評価する
  • 2019 - 2022 動物モデルと数理モデルを用いた放射線発がん線量率効果が生じるメカニズムの解明
  • 2015 - 2020 Development of rat models as a component technology for visualizing the process of radiation-induced carcinogenesis
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Papers (79)：
  • Ryoko Semba, Takamitsu Morioka, Hiromi Yanagihara, Kenshi Suzuki, Hirotaka Tachibana, Takahiro Hamoya, Yoshiya Horimoto, Tatsuhiko Imaoka, Mitsue Saito, Shizuko Kakinuma, et al. Corrigendum to "Azithromycin induces read-through of the nonsense Apc allele and prevents intestinal tumorigenesis in C3B6F1 ApcMin/+ mice" [Biomed. Pharmacother. 164 (2023) 114968]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023. 165. 115082-115082
  • Ryoko Semba, Takamitsu Morioka, Hiromi Yanagihara, Kenshi Suzuki, Hirotaka Tachibana, Takahiro Hamoya, Yoshiya Horimoto, Tatsuhiko Imaoka, Mitsue Saito, Shizuko Kakinuma, et al. Azithromycin induces read-through of the nonsense Apc allele and prevents intestinal tumorigenesis in C3B6F1 Apc/+ mice. Biomedicine and Pharmacotherapy. 2023. 164. 114968-114968
  • Yasuharu Ninomiya, Tatsuhiko Imaoka, Kazuhiro Daino, Shizuko Kakinuma, Tetsuo Nakajima. Arsenite-induced Radiosensitization of Glioma Cells Is Dependent on p53 Deficiency. Anticancer Research. 2023. 43. 6. 2551-2559
  • Hiromi Yanagihara, Takamitsu Morioka, Shunsuke Yamazaki, Yutaka Yamada, Hirotaka Tachibana, Kazuhiro Daino, Chizuru Tsuruoka, Yoshiko Amasaki, Mutsumi Kaminishi, Tatsuhiko Imaoka, et al. Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice†. Journal of Radiation Research. 2023. 64. 3. 622-631
  • Keiji Suzuki, Tatsuhiko Imaoka, Masanori Tomita, Megumi Sasatani, Kazutaka Doi, Satoshi Tanaka, Michiaki Kai, Yutaka Yamada, Shizuko Kakinuma. Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part I: Mammary gland and digestive tract. Journal of Radiation Research. 2023. 64. 2. 210-227
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MISC (103)：
  • 永田健斗, 西村まゆみ, 臺野和広, 臺野和広, 飯塚大輔, 飯塚大輔, 西村由希子, 西村由希子, 服部佑哉, 渡邊立子, et al. Analysis of early cellular dynamics leading to radiation carcinogenesis in rat mammary gland. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 西村由希子, 神長輝一, 宇佐美徳子, 横谷明徳, 今岡達彦. Does sparse radiation exposure affect rat mammary cell competition?. KEK Progress Report (Web). 2023. 2023-2
  • 西村由希子, 神長輝一, 宇佐美徳子, 横谷明徳, 今岡達彦. Beam position adjustment required in X-ray microbeam irradiation of two-dimensionally cultured rat mammary cells expressing fluorescent proteins. KEK Progress Report (Web). 2022. 2022-5
  • 永田健斗, 西村まゆみ, 臺野和広, 飯塚大輔, 西村由希子, 服部佑哉, 渡辺立子, 横谷明徳, 柿沼志津子, 今岡達彦. Radiation suppresses differentiation of rat mammary luminal cells depending on dose rate. アイソトープ・放射線研究発表会(Web). 2022. 59th
  • 渡辺光, 渡辺光, 臺野和広, 石川敦子, 今岡達彦, 今岡達彦, 西村まゆみ, 高畠賢, 高畠賢, 井上一雅, et al. Identification of fusion genes in radiation-induced rat mammary carcinomas using RNA sequencing. 日本毒性病理学会講演要旨集. 2022. 38th
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Works (14)：
  • 財団法人武田科学振興財団生命科学研究奨励「発がん標的としての組織幹細胞のDNA損傷応答に関する研究」
    2009 - 2010
  • 文部科学省原子力基礎基盤戦略研究イニシアティブ若手原子力研究プログラム「放射線発がんの非遺伝子変異的過程の解明」
    2009 - 2010
  • Young Scientists Nuclear Energy Research Program, Nuclear Energy Fundamental Strategic Research Initiative (personal translation) from MEXT
    2009 - 2010
  • Grant from the Takeda Science Foundation
    2009 - 2010
  • 文部科学省科学研究費補助金若手研究(B)「新規遺伝子の機能解析による放射線特異的な乳癌誘発メカニズムの解明」
    2008 - 2010
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Education (4)：
  • 1997 - 2002 The University of Tokyo Graduate School of Science Department of Biological Sciences
  • 1995 - 1997 The University of Tokyo School of Science Zoology
  • 1993 - 1995 The University of Tokyo College of Arts and Sciences Natural Sciences I
  • 1990 - 1993 Azabu High School
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (30)：
  • 2024/04 - 現在 National Institutes for Quantum Science and Technology Quantum Cancer Science Team, Quantum Life Sensing Group, Institute for Quantum Life Science Team Leader
  • 2024/04 - 現在 National Institutes for Quantum Science and Technology Research Promotion Office, Institute for Radiological Science
  • 2024/04 - 現在 National Institutes for Quantum Science and Technology Biomarker Research Group, Department of Radiation Effects Research, Institute for Radiological Science Group Leader
  • 2020/04 - 現在 Tokyo Metropolitan University
  • 2023/04 - 2024/03 National Institutes for Quantum Science and Technology Radiological Sciences Promotion Group, Department of Research Planning and Promotion, Quantum Life and Medical Science Directorate Group Leader
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Committee career (25)：
  • 2022/07 - 現在 Japanese Radiation Research Society Member of Financial Committee, Member of Academic Committee, Member of Awards Committee
  • 2022/06 - 現在 Japanese Radiation Research Society Executive Director (Vice President), Councilor, Chair of Globalization Committee
  • 2020/01 - 現在 Journal of Radiation Research Associate Editor
  • 2020 - 現在 Institute for Environmental Sciences [Research Evaluation Committee]
  • 2019/01 - 現在 International Commission on Radiological Protection (ICRP) Task Group 111 Corresponding Member
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Awards (7)：
  • 2023/07 - National Institutes for Quantum Science and Technology President's Commendation (R&D Achievement Award) Animal Model of Susceptibility to Environmental Carcinogenesis
  • 2010/07 - 独立行政法人放射線医学総合研究所 平成22年度特別表彰
  • 2010/03 - 財団法人放射線影響協会 第4回放射線影響研究奨励賞 放射線防護の精緻化に資する影響評価研究及び放射線発がん機序の解明研究
  • 2009/07 - National Institute of Radiological Sciences Special Commendation of National Institute of Radiological Sciences
  • 2008/11 - Japanese Radiation Research Society Young Investigator Award
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Association Membership(s) (5)：
Japan Society for Biomedical Gerontology ,  Japan Health Physics Society ,  Quantum Life Science Society ,  The Japanese Cancer Association ,  Japanese Radiation Research Society
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