Sakuda Shohei

サクダショウヘイ | Sakuda Shohei

Affiliation and department：
Job title： Professor, Dean
Homepage URL (1)： https://www.teikyo-u.ac.jp/faculties/undergraduate/science_tech/bio_science_sakuta.html

Research field (1)： Bioorganic chemistry

Research keywords (10)：生合成 , 生物活性物質 , キチナーゼ , マイコトキシン , 二次代謝産物 , biosynthesis , bioactive compounds , chitinase , mycotoxin , secondary metabolite

Research theme for competitive and other funds (28)：

2021 - 2025 フザリウムによる真菌性角膜炎の重症化におけるマイコトキシンの関与の解明
2017 - 2021 Creation of next-generation pest control drugs by elucidation of the indirect defence mechanism of plants
2011 - 2014 Analysis of molecular mechanism of anti-asthmatic activity of allosamidin by focusing the function of chitinase-like proteins
2010 - 2012 New method for identifying target molecules of bioactive compounds
2008 - 2010 The study on mycotoxin detoxification and protection of animal mycotoxicoses in Thaoland.

2008 - 2010 Development of chemical biology based on allosamidin molecule

2005 - 2009 Regulation mechanism of biomineralization based on interaction between organic matrices and inorganic crystals

2007 - 2008 アフラトキシンの生産菌における生理的役割に関する研究

2005 - 2007 Analysis of a physiological role and anti-asthmatic activity of the chitinase inhibior allosamidin

2005 - 2006 Modulation of Cytokine Signals and Treatment for Inflammatory Lung Diseases

2001 - 2002 アフラトキシン生産阻害物質を用いたアフラトキシン生産調節機構の解析

2000 - 2001 Isolation and identification of a self-growth-inhibiting substance produced by Legionella sp. and its application as an anti-Legionella drug

1999 - 1999 雲南地域の植物性抗がん剤に関する研究

1998 - 1998 Studies of Floral Antitumor Medicines in Yunnan Province

1996 - 1998 Search for bioactive substances acting on insect neuropeptide receptors and application of them to insect growth requlators.

1997 - 1997 Studies of Floral Antitumor Medicines in Yunnan Province

1996 - 1996 Studies of Floral Antitumor Medicines in Yunnan Province

1995 - 1995 Studies of Floral Antitumor Medicines in Yunnan Province

1992 - 1993 Disturibution and function of autoregulator jin streptomyces species producing antibiotics

1992 - 1993 Biosynthesis of the chitinase inhibitor allosamidin produced by Streptomyces

1990 - 1991 Distribution and function of novel inducing factor for secondary metabolism

1988 - 1990 Screening of Virginiamycin Inducing Factors in Antibiotic-Producing Atcinomycetes

アフラトキシン生産阻害物質に関する研究

微生物の生産する生理活性物質に関する研究

キチナーゼ阻害物質に関する研究

Studies on inhibitors of aflatoxin production

studies on bioactive compounds produced by microorganisms

Studies on chitinase inhibitors

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Papers (133)：

Shohei Sakuda, Masaki Sunaoka, Maho Terada, Ayaka Sakoda, Natsumi Ishijima, Noriko Hakoshima, Kenichi Uchida, Hirofumi Enomoto, Tomohiro Furukawa. Inhibition of Aflatoxin Production in Aspergillus flavus by a Klebsiella sp. and Its Metabolite Cyclo(l-Ala-Gly). Toxins. 2024. 16. 3. 141-141
Abdelrahman Elamin, Hirofumi Enomoto, Maiko Watanabe, Shohei Sakuda. The Mechanism of Ochratoxin Contamination of Artificially Inoculated Licorice Roots. Toxins. 2023. 15. 3
Lingxiao Zhu, Keisuke Shimizu, Hiroyuki Kintsu, Lumi Negishi, Zehua Zheng, Hitoshi Kurumizaka, Shohei Sakuda, Isao Kuriyama, Takashi Atsumi, Kaoru Maeyama, et al. Structural and functional analyses of chitinolytic enzymes in the nacreous layer of Pinctada fucata. BIOCHEMICAL ENGINEERING JOURNAL. 2023. 191
Tomohiro Furukawa, Masayo Kushiro, Hiroyuki Nakagawa, Hirofumi Enomoto, Shohei Sakuda. Low-dose ethanol increases aflatoxin production due to the adh1-dependent incorporation of ethanol into aflatoxin biosynthesis. iScience. 2023. 106051-106051
Naoyuki Umemoto, Natsuki Saito, Masato Noguchi, Shin-Ichiro Shoda, Takayuki Ohnuma, Takeshi Watanabe, Shohei Sakuda, Tamo Fukamizo. Plant Chitinase Mutants as the Catalysts for Chitooligosaccharide Synthesis Using the Sugar Oxazoline Derivatives. Journal of agricultural and food chemistry. 2022. 70. 40. 12897-12906

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MISC (163)：

井之口曜, 古川智宏, 吉成知也, 作田庄平. プロテインチロシンホスファターゼ阻害剤blasticidin Aおよびdephostatinによるアフラトキシン生産阻害(Inhibition of aflatoxin production by protein tyrosine phosphatase inhibitors, blasticidin A and dephostatin). JSM Mycotoxins. 2019. 69. 2. 71-79
古川智宏, 作田庄平. 外部から加えたスーパーオキシド消去酵素によるアフラトキシン生産の制御機構. 日本農芸化学会大会講演要旨集(Web). 2019. 2019. ROMBUNNO.1D1a06 (WEB ONLY)
作田庄平. Progress in bioorganic chemistry on allosamidin and aflastatin, microbial metabolites that control metabolism. The Japanese journal of antibiotics. 2019. 72. 1. 31-40
SAKUDA Shohei. Progress in bioorganic chemistry on allosamidin and aflastatin, microbial metabolites that control metabolism. The Japanese Journal of Antibiotics. 2019. 72. 1. 31-40
飯村九林, 古川智宏, 山本利義, 根岸瑠美, 鈴木道生, 作田庄平. cyclo(L-Ala-L-Pro)のアフラトキシン生産阻害機構の解明. 日本農芸化学会大会講演要旨集(Web). 2018. 2018. ROMBUNNO.3A15p05 (WEB ONLY)

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Patents (5)：

サーモスポロスリックス・ハザケンシス(Thermosporothrix hazakensis)由来の抗菌活性物質
アフラトキシン産生阻害剤及びアフラトキシン汚染防除方法
アフラトキシン産生阻害剤及びその製造方法、ノルソロリン酸産生阻害剤、mRNA発現抑制剤、並びに、アフラトキシン汚染防除方法
アフラトキシン産生阻害剤、及びアフラトキシン汚染防除方法
アフラトキシン生産阻害剤、及びそれを用いたアフラトキシン汚染防除方法

Books (1)：

Aflastatins : New streptomyces metabolites that inhibit aflatoxin(共著)
Biologically active natural products : agrochemicals 1999

Lectures and oral presentations (12)：

Chemical biology in mycotoxin research
(International Symposium of Mycotoxicology 2022 & International Conference of Mycotoxicology and Food Security 2022)
Mycotoxin Researchers in Japan
(Mycokey Conference Italy-2020 2020)
Japan in focus: a close look at regulatory issues for mycotoxins and recent advance in mycotoxin research
(2020)
Aflatoxin production inhibitors -Two decades from aflastatin A
(International Conference of Mycotoxicology and Food Security 2019)
Key molecules in primary metabolism for mycotoxin production
(2nd Mycokey International Conference 2018)

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Education (2)：

- 1986 The University of Tokyo
- 1982 The University of Tokyo

Professional career (1)：

(BLANK) (The University of Tokyo)

Work history (3)：

2018/04 - 現在 Teikyo University Faculty of Science and Engineering
1994/11 - 2018/03 The University of Tokyo Graduate School of Agricultural and Life Sciences
1986 - 1994 Osaka University School of Engineering

Committee career (4)：

2022 - 現在 Japanese Society for Chitin and Chitosan President
2016/01 - 現在 Japanese Society of Mycotoxicology President
2006 - 2009 日本放線菌学会理事
2005 - 2008 日本農芸化学会理事

Awards (3)：

2009 - 日本マイコトキシン学会学術賞
2001 - 日本抗生物質学術協議会住木・梅澤記念賞
1994 - 農芸化学奨励賞

Association Membership(s) (4)：

日本キチン・キトサン学会 , 日本放線菌学会 , 日本マイコトキシン学会 , 日本農芸化学会

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