Negishi Yoichi

ネギシヨウイチ | Negishi Yoichi

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： http://kaken.nii.ac.jp/ja/r/50286978 , http://www.ps.toyaku.ac.jp/lab/sotu/15.pdf

Research field (4)： Pharmacology , Pharmaceuticals - health and biochemistry , Clinical pharmacy , Medical systems

Research keywords (14)：ゲノム編集 , 超音波 , セラノスティクス , 光音響 , ナノバブル , 癌 , 循環器疾患 , 脳 , muscular dystrophy , Drug delivery system , 核酸 , ナノ粒子 , リポソーム , 遺伝子治療

Research theme for competitive and other funds (26)：

2023 - 2026 Development of novel nanobubbles composed of antibody drugs and ultrasound contrast gas and their potential applications
2022 - 2025 Development of a non-invasive glaucoma treatment using ultrasonic nanobubbles associated with anti-LRP1 antibody
2022 - 2025 経鼻投与型核酸搭載ナノバブルの開発と中枢神経系疾患の超音波治療システムの基盤構築
2021 - 2025 Design of Diffusive pDNA Carrier for In Vivo Unexplored Space and In Situ Stem Cell Regenerative Medicine
2021 - 2024 Development of ultrasound-responsive nanobubbles specialized on heart failure and construction of a disease treatment system

2021 - 2024 Development of innovative RNA vaccine system using ultrasound-responsive nanobubbles

2019 - 2022 Development of novel theranostics system using photoacoustic and ultrasound-responsive nanobubbles

2018 - 2021 Development of ultrasound-responsive nanobubbles containing genome editing tools and establishment of disease treatment system

2016 - 2019 Preparation of highly-condensed plasmid DNA for delivery to unexplored space in vivo

2016 - 2019 Development of antibody delivery system by ultrasound responsive nano bubble and breast cancer treatment strategy

2015 - 2018 Research on Fukuyama musucular dystrophy towards clincal trial using antisense oligonucleotids

2015 - 2018 Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system

2013 - 2016 Ultrasound-mediated gene delivery system into brain tissue by blood brain barrier targeting Bubble liposomes

2011 - 2014 Therapeutic systems of muscular dystrophy by morpholino oligonucleotide-loaded nanobubble and ultrasound

2010 - 2012 IL-6 acts as a key cytokine in the augmentation of mucosal immunity following intranasal administration of antigen with liposomes

2010 - 2012 Gene transfer system into mesenchymal stem cell by peptide-modified liposomes and ultrasound technology

2008 - 2010 Low invasive therapeutic system for vascular diseases by neovascular specific liposomes containing US-contrast gas

2006 - 2007 新規な超音波造影ガス封入リポソームによる非侵襲的虚血性血管再生療法のシステム開発

2005 - 2006 The promotional effect for bone formation by ultrasound mediated gene transfer (sonoporation) on osteogenetic gene at sites of distraction osteogenesis

2004 - 2005 NF-κB DNA decoyを用いた炎症関連遺伝子発現の調節による歯周病態制御

2004 - 2005 The effect of gravitational alteration on the formation and activation of osteoclast.

2003 - 2005 関節軟骨疾患をターゲットとした細胞周期調節因子p21遺伝子による軟骨再生の試み

2003 - 2004 顎関節腔内滑膜病変に対するGDF-5遺伝子導入による修復効果

2003 - 2004 Study of osteogenetic effect on the fracture callus of facial bone by LRP5 gene transfer

2000 - 2002 The changes of bone metabolism induced by quasi-microgravity and its recovery by the bone-metabolizing agents.

1998 - 1999 CO-OPERATIVE EFFECTS OF HYPERGRAVITY AND BONE FORMING AGENTS ON THE METABOLISM OF OSTEOBLASTS

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Papers (104)：

Yusuke Yano, Rui Tada, Nobuhito Hamano, Kenshin Haruta, Tomomi Kobayashi, Masahiro Sato, Yamato Kikkawa, Yoko Endo-Takahashi, Motoyoshi Nomizu, Yoichi Negishi. Development of a concise and reliable method for quantifying the antibody loaded onto lipid nanoparticles modified with Herceptin. Journal of Immunological Methods. 2023. 521. 113554-113554
Shohko Sekine, Sayaka Mayama, Nobuaki Nishijima, Takuo Kojima, Yoko Endo-Takahashi, Yuko Ishii, Hitomi Shiono, Saki Akiyama, Akane Sakurai, Sanae Sashida, et al. Development of a Gene and Nucleic Acid Delivery System for Skeletal Muscle Administration via Limb Perfusion Using Nanobubbles and Ultrasound. Pharmaceutics. 2023. 15. 6. 1665
Rui Tada, Haruka Yamazaki, Yuzuho Nagai, Yukino Takeda, Akihiro Ohshima, Jun Kunisawa, Yoichi Negishi. Intranasal administration of sodium nitroprusside augments antigen-specific mucosal and systemic antibody production in mice. International Immunopharmacology. 2023. 119. 110262-110262
Yusuke Yano, Nobuhito Hamano, Kenshin Haruta, Tomomi Kobayashi, Masahiro Sato, Yamato Kikkawa, Yoko Endo-Takahashi, Rui Tada, Ryo Suzuki, Kazuo Maruyama, et al. Development of an Antibody Delivery Method for Cancer Treatment by Combining Ultrasound with Therapeutic Antibody-Modified Nanobubbles Using Fc-Binding Polypeptide. Pharmaceutics. 2023. 15. 1. 130-130
Rui Tada, Koichiro Nagao, Riki Tanaka, Sumire Yamada, Ayano Watanabe, Yoichi Negishi. Involvement of splenic marginal zone macrophages in the recognition of systemically administered phosphatidylserine-coated liposomes in mice. International Immunopharmacology. 2022. 112. 109209-109209

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MISC (95)：

韮沢慧, 楢木侑子, 濱田圭佑, 片桐文彦, 高橋葉子, 吉川大和, 野水基義, 根岸洋一. エンドソーム脱出能を付与した筋指向性遺伝子デリバリーシステムの開発. 日本DDS学会学術集会プログラム予稿集. 2019. 35回. 132-132
滝澤菜緒, 佐藤加奈子, 大谷嘉典, 高橋葉子, 鈴木亮, 丸山一雄, 馬場広子, 新槇幸彦, 根岸洋一. 中枢神経系組織への遺伝子導入を指向したPolyplex搭載型バブルリポソームの開発. 日本薬剤学会年会講演要旨集(Web). 2017. 32nd. ROMBUNNO.P13-45 (WEB ONLY)-258
鈴木亮, 小田雄介, 小俣大樹, Unga Johan, 宇留賀仁史, 杉井むつみ, 根岸洋一, 丸山一雄. 低侵襲的な超音波がん温熱免疫療法の開発に向けた基礎的検討. 超音波医学. 2016. 43. 5. 679-679
指田紗菜恵, 根岸洋一, 道鎭えりか, 片桐文彦, 高橋葉子, 鈴木亮, 丸山一雄, 野水基義, 新槇幸彦. バブルリポソームと超音波照射併用による筋ジストロフィーモデルマウス横隔膜への核酸デリバリー. 日本DDS学会学術集会プログラム予稿集. 2016. 32回. 148-148
根岸洋一. Establishment of Drug Delivery System in the Combination of Tumor Targeting Nano-bubble with High-intensity Focused Ultrasound. 薬学研究の進歩. 2016. 32. 57-61

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Patents (6)：

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Books (3)：

薬物送達システム
最新薬剤学廣川書店 2018
ペプチド修飾リポソームによるDDS,医療・診断をささえるペプチド科学-再生医療・DDS・診断への応用-.
シーエムシー出版 2017
“バブルリポソームによる超音波核酸デリバリーシステム”,ドラッグデリバリーシステムの新展開II-核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-.
2012

Professional career (1)：

Ph.D.

Work history (12)：

2019/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Professor
2006/12 - 現在 Showa University School of Dentistry
2007/04 - 2019/03 東京薬科大学薬学部 Associate Professor
2012/04 - 2013/03 国立精神神経医療研究センター神経研究所客員研究員
2004/10 - 2007/03 東京薬科大学薬学部講師

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Committee career (8)：

2021/05 - 現在日本DDS学会評議員
2020/12 - 現在日本薬学会代議員(関東支部)
2019/12 - 現在日本超音波治療研究会執行役員
2018/04 - 現在日本薬剤学会代議員
2015/04 - 現在 Scientific Reports (Nature Publishing Group) Editorial board member

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Association Membership(s) (10)：

日本筋学会 , 日本核酸医薬学会 , 米国超音波治療学会(ISTU) , 米国遺伝子細胞治療学会(ASGCT) , 日本超音波診断治療研究会 , 遺伝子・デリバリー研究会 , 日本DDS学会 , 日本薬剤学会 , 日本薬学会 , 日本ゲノム編集学会

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