Rchr
J-GLOBAL ID：200901011672497027   Update date: Apr. 05, 2024

Takasawa Shin

タカサワ シン | Takasawa Shin
Affiliation and department：
Nara Medical University Faculty of Medicine / School of Medicine, Department of Biochemistry

About Nara Medical University Faculty of Medicine / School of Medicine, Department of Biochemistry


Job title： Professor
Homepage URL  (1)： http://www.naramed-u.ac.jp/~bioch/
Research field  (3)： Metabolism and endocrinology ,  Pathobiochemistry ,  Medical biochemistry
Research keywords  (9)： 生活習慣病 ,  intermittent hypoxia ,  pancreatic β-cells ,  Reg gene ,  insulin secretion ,  CD38 ,  cyclic ADP-ribose ,  Reg遺伝子 ,  サイクリックADPリボース
Research theme for competitive and other funds  (31)：
  • 2011 - 2012 Translational control of glucose-induced insulin biosynthesis
  • 2010 - 2012 The pathoetiology of destruction and regeneration in salivary gland of Sjogren's syndrome
  • 2006 - 2007 Targeted disruption of the Reg protein receptor gene : The relationship of the Reg-Reg receptor system with pancreatic 13-cell replication.
  • 2005 - 2006 Regulation of the CD38-cyclic ADP-ribose signal system by tissue-specific slicing of ryanodine receptor
  • 2004 - 2005 インスリン産生細胞増殖因子RegのCDK阻害系による細胞周期調節
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Papers (116)：
  • Yoshinori Takeda, Fuminori Kimura, Shin Takasawa. Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia. Life. 2024. 14. 1. 157-157
  • Shin Takasawa, Mai Makino, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Rina Hirota, Ryusei Fujii, Keito Asai, Yoshinori Takeda, Tomoko Uchiyama, Ryogo Shobatake, et al. Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1. Journal of cellular and molecular medicine. 2023
  • 高澤 伸, 牧野 舞, 山内 晶世, 土田 澄代, 廣田 梨奈, 藤井 龍星, 朝井 啓斗, 竹田 善紀, 内山 智子, 正畠 良悟, et al. 間歇的低酸素は血管内皮細胞のICAM-1,ESM1 mRNAを増加させる. 糖尿病. 2023. 66. Suppl.1. S-176
  • Shin Takasawa, Ryogo Shobatake, Asako Itaya-Hironaka, Mai Makino, Tomoko Uchiyama, Sumiyo Sakuramoto-Tsuchida, Yoshinori Takeda, Hiroyo Ota, Akiyo Yamauchi. Upregulation of IL-8, osteonectin, and myonectin mRNAs by intermittent hypoxia via OCT1- and NRF2-mediated mechanisms in skeletal muscle cells. Journal of cellular and molecular medicine. 2022. 26. 24. 6019-6031
  • 高沢 伸, 牧野 舞, 内山 智子, 山内 晶世, 土田 澄代, 広中 安佐子, 竹田 善紀, 朝井 啓斗, 正畠 良悟, 太田 浩世. 間歇的低酸素は心筋細胞でPtenの発現を介して心筋機能に重要なCD38-cyclic ADP-ribose情報伝達系コンポーネントの発現低下を引き起こす. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T14a-09
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MISC (635)：
  • Uchiyama, T, Ota, H, Ohbayashi, C, Takasawa, S. Intermittent hypoxia and cytokines. Encyclopedia. 2021. 18161
  • Takasawa, S, Itaya-Hironaka, A, Yamauchi, A, Makino, M, Sakuramoto-Tsuchida, S, Uchiyama, T, Takeda, Y, Kyotani, Y, Ota, H. Up-regulation of regenerating gene IV and hepatocyte growth factor in cardiomyocytes by intermittent hypoxia and its microRNA-mediated mechanism. Diabetes. 2021. 70. Suppl. 1. 378-P-378-P
  • Makino, M, Itaya-Hironaka, A, Yamauchi, A, Sakuramoto-Tsuchida, S, Takeda, Y, Uchiyama, T, Takasawa, S. Alteration of alternative splicing of Ryr2 modulates insulin biosynthesis in pancreatic β-cells. Diabetes. 2021. 70. Suppl. 1. 1252-P-1252-P
  • 正畠良吾, 山内晶世, 牧野 舞, 内山智子, 土田澄代, 京谷陽司, 太田浩世, 広中安佐子, 高橋信行, 高沢 伸. 間歇的低酸素は哺乳類骨格筋細胞において糖尿病関連ミオカインのmRNAを増加させる. 糖尿病. 2020. 66 (Suppl. 1). S-349-S-349
  • 太田浩世, 内山智子, 山内基雄, 藤田幸男, 広中安佐子, 土田澄代, 山内晶世, 高沢 伸, 室 繁郎. 間歇的低酸素曝露はmicroRNA452の発現低下を介して脂肪細胞のResistin、TNFα、CCL2の発現、分泌増加を引き起こす. 日本呼吸器学会誌. 2020. 9(増刊). 増刊. 239-239
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Books (10)：
  • Pancreatic Islet Biology
    Springer 2016
  • Sjögren's Syndrome
    Nova Biomedical 2014
  • Encyclopedia of Molecular Medicine
    John Wiley & Sons, Inc. 2002
  • Cyclic ADP-ribose and NAADP: Structure, Metabolism and Physiological Functions
    Kluwer 2002
  • Human CD38 and related molecules/Recent Advances in CD38 and Related Molecules
    Karger 2000
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Lectures and oral presentations  (400)：
  • Intermittent hypoxia increased the expression of DBH and PNMT in neuronal cells via microRNA-mediated mechanism.
    (82nd American Diabetes Association Scientific Sessions 2022)
  • 間歇的低酸素は神経細胞においてカテコールアミン合成酵素mRNAを増加させる
    (第65回日本糖尿病学会年次学術集会 2022)
  • Intermittent hypoxia up-regulates Renin and Cd38 mRNAs in renin-producing cells via miR-203.
    (European Respiratory Society (ERS) International Congress 2021 2021)
  • Up-regulation of regenerating gene IV and hepatocyte growth factor in cardiomyocytes by intermittent hypoxia and its microRNA-mediated mechanism.
    (81st American Diabetes Association Scientific Sessions 2021)
  • Alteration of alternative splicing of Ryr2 modulates insulin biosynthesis in pancreatic β-cells.
    (81st American Diabetes Association Scientific Sessions 2021)
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Works (1)：
  • REG遺伝子発現によるがんの予後診断法の実用化と治療薬のグランドデザインの確立
    2006 - 2008
Education (6)：
  • 1985 - 1986 Tohoku University, Graduate School of Medicine Graduate School of Medicine Biochemistry
  • - 1986 Tohoku University
  • - 1986 Tohoku University Graduate School, Division of Medicine
  • 1983 - 1985 Toyama Medical and Pharmaceutical University Graduate School, Division of Medicine Biochemistry
  • - 1983 Yamagata University School of Medicine Medicine
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Professional career (2)：
  • Doctor of Medical Science (Tohoku University)
  • 医学博士 (東北大学)
Work history (6)：
  • 2007/04 - Nara Medical University School of Medicine Professor & Chairman (Department of Biochemistry)
  • 2006/04/01 - 2007/03/31 Tohoku University Graduate School of Medicine. Department of Advanced Biological Sciences for Regeneration (Kotobiken Medical Laboratories) Professor
  • 1999/04/01 - 2006/03/31 Tohoku University Graduate School of Medicine. Department of Biochemistry Associate Professor
  • 1996/10/01 - 1999/03/31 Tohoku University School of Medicine. Department of Biochemistry Associate Professor
  • 1993/08/01 - 1996/09/30 Tohoku University School of Medicine. Department of Biochemistry Lecturer
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Committee career (8)：
  • 2018/07 - 2019/06 日本学術振興会 特別研究員等審査会専門委員、卓越研究員候補者選考委員会書面審査員、国際事業委員会書面審査員・書面評価員
  • 2013/12 - 2015/11 日本学術振興会 科学研究費審査委員
  • 2010/12 - 2012/11 日本学術振興会 科学研究費審査委員
  • 2010/09/01 - 2012/08/31 日本生化学会 代議員
  • 2010/09/01 - 2012/08/31 Japanese Biochemical Society Representative
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Awards (16)：
  • 2021/04 - Life Sciences Best Reviewer Award 2020 (Life Sciences)
  • 2019/10/21 - Spandidos Publications Excellence in Reviewing Award in Exp. Ther. Med.
  • 2019/06 - Recognized Reviewer
  • 2018/10 - Recognized Reviewer
  • 2018/10 - Recognized and Outstanding Reviewer
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Association Membership(s) (19)：
日本細菌学会 ,  アジア糖尿病学会 ,  欧州糖尿病学会 ,  米国糖尿病学会 ,  日本癌学会 ,  日本糖尿病学会 ,  Japanese Biochemical Society ,  日本生化学会東北支部(1996/10-2004/03 世話人) ,  Japanese Society for Bacteriology ,  Asian Association for the Study of Diabetes ,  European Association for the Study of Diabetes ,  American Diabetes Association ,  Japanese Cancer Association ,  Japanese Diabetes Society ,  Japanese Biochemical Society ,  日本生化学会東北支部 ,  奈良医学会 ,  日本生化学会関西支部 ,  日本糖尿病・妊娠学会
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