Research theme for competitive and other funds (29)：
2023 - 2026 Investigation of compounds that mimic the effects of calorie restriction on healthy life extension and their mechanisms of action
2020 - 2024 Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein response
2019 - 2022 Mechanisms underlying the anti-aging effect of calorie restriction: Roles for FoxO transcription factors in macrophages
2018 - 2021 Roles of FMO3 in aging and carcinogenesis under calorie restriction
2017 - 2019 Functional analysis of inflammation-related microRNA in non-alcoholic steatohepatitis and antisense oligodeoxynucleotide development
2016 - 2019 Analysis the aging mechanisms via WDR6 and aim for building new animal aging model
2016 - 2019 Comprehensive analysis for wound inflammation-related miRNAs and development of novel therapies
2015 - 2019 Regulation of cancer and aging by FoxO and investigation of compounds for regulation of FoxO
2015 - 2018 Functional analysis of WDR6, a novel energy metabolism related gene
2014 - 2017 Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung
2012 - 2014 Calorie restriction associated microRNA: Possibility of biomarkers of human aging-dependent diseases
2010 - 2014 Regulation of the aging by calorie restriction: Implications of mitochondrial retrograde signals
2011 - 2013 The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung
2008 - 2010 The effects of adiponectin on lung cancer and lung disease
2007 - 2008 Mechanisms underlying the effect of calorie restriction : Analyses of neuropeptide Y and receptor subtypes
2007 - 2008 Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXR
2004 - 2005 Investigation of genes involved in anti-obesity and insulin sensitivity in the white adipose tissue
2003 - 2005 Regulation of aging in mammals : Difference between the effects of calorie restriction and suppression of the GH-IGF-1 axis
2000 - 2001 What is the target of anti-aging action of calorie restriction?
2000 - 2001 Mechanisms underlying the anti-aging effect of caloric restriction: A role for leptin in regulation of neuroendocrine system
1998 - 2000 Clinical and basic research on the diagnosis and cause of aortic dissection
1990 - Mechanisms of antiaging effect of calorie restriction
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Papers (192)：
Isao Shimokawa. Mechanisms underlying retardation of aging by dietary energy restriction. Pathology international. 2023. 73. 12. 579-592
Eiko Inamasu, Tomoshi Tsuchiya, Motohiro Yamauchi, Kodai Nishi, Katsuya Matsuda, Fumio Sugawara, Kengo Sakaguchi, Ryoichi Mori, Keitaro Matsumoto, Takuro Miyazaki, et al. Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models. Journal of radiation research. 2022. 63. 1. 19-29
Tajima, K., Fukushima, N., Kira, K., Togo, M., Shibata, M., Mawatari, S., Hayashi, H., Shimokawa, I., Takeshima, F., Nakao, K. A case of hepatitis C-related cirrhosis that developed cancer of unknown primary origin and followed with fulminant course after treatment with direct-acting antivirals. Kanzo/Acta Hepatologica Japonica. 2022. 63. 2
Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa. The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis. Biomedicines. 2021. 9. 11. 1739-1739
Park, S., Mori, R., Shimokawa, I. The fat regulator neuropeptide Y and caloric restriction. Aging. 2021. 9. 11
森亮一, KIM Sang Eun, 亀岡章一郎, 元岡大祐, 奥崎大介, 林洋子, 下川功. Cell-cell interactions in microenvironment of skin wound sites using spatial transcriptome analysis. 日本病理学会会誌. 2021. 110. 1
Mechanisms Underlying Retardation of Aging Processes by Dietary Energy Restriction
(112th Annual Meeting 2023 2023)
A regulatory mechanism of the aging procees from the dietary restriction model
(2023)
Regulation of the aging process by dietary calorie restriction
(The 19th Annual Meeting of Functional Food Society 2023)
Roles for FoxO3 in mitochondrial and metabolic responses to dietary restriction
(14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology 2022)
Investigation of anti-aging herbal medicines
2010 - 2011
成長ホルモン(GH)抑制トランスジェニックラットの老化研究への応用
1999 - 2001
Education (2)：
1982 - 1986 Nagasaki University Graduate School of Medical Sciences Pathology
1976 - 1982 Nagasaki University School of Medicine School of Medical Sciences
Professional career (2)：
PhD (Nagasaki University)
MD (Nagasaki University)
Work history (2)：
2000/04 - 2023/01 Nagasaki University School of Medicine Professor
1988/08 - 1990/08 University of Texas Health Science Center at San Antonio Department of Physiology Research assistant
Awards (3)：
2023/04 - The Japanese Society of Pathology Japan Pathology Award Mechanisms Underlying Retardation of Aging Processes by Dietary Energy Restriction
2009 - Gerontological Society of America Fellow of the Gerontological Society of America
2003/11 - The Japanese Society of Pathology Research Award A of the Japanese Society of Pathology
Association Membership(s) (8)：
アメリカ老化協会
, 日本病理学会
, 日本基礎老化学会
, アメリカ老化学会
, American Aging Association
, The Japanese Society of Pathology
, Japan Society for Biomedical Gerontology
, Gerontological Society of America
