Research theme for competitive and other funds (21)：
2022 - 2025 Elucidation of metastasis mechanism by constructing in vitro cancer metastasis model
2019 - 2022 Elucidation and control of pancreatic cancer-stroma interaction by artificial cancer tissue construction
2018 - 2020 Semi-exhaustive functional screening of cell-cell interaction factors in human iPSC mini-liver
2016 - 2019 Clarification of the role of CD13 combined with N-terminal fragment of fibronectin on inflammatory bone resorption.
2016 - 2018 Single cell heterogeneity analysis of endothelial and mesenchymal cells
2015 - 2018 Dissecting pancreatic cancer cell evolution at single cell level.
2016 - 2018 Cell lineage analysis of changes in characteristics of pancreatic cancer cells at single cell level(Fostering Joint International Research)
2013 - 2017 Generation of pancreatic islet-like tissue by using an innovative 3D-culture method.
2014 - 2016 Visualization of functional hepatic cells derived from human iPS cells.
2012 - 2015 Identification of pancreatic cancer stem cell lineage during pancreatic tumorigenesis
2012 - 2014 Elucidation of liver carcinogenesis mechanism by epigenetic reprogramming.
2010 - 2012 Investigation of the role of endogenous Wnt signaling in osteoclast differentiation and function
2009 - 2011 Regulatory mechanisms of gene expression in anti-inflammatory M2 macrophages
2009 - 2010 Molecular mechanisms of resistance to interferon-gamma in human oral squamous carcinoma.
2005 - 2009 Mechanism of liver development
2007 - 2008 Molecular dissection of interferon-resistance in oral squamous cell carcinoma
2007 - 2008 Mechanism of Transcriptional Repression of Inflammatory Gene Expression by STAT1
2007 - 2008 A fundamental study about development of the protein therapy using suppressors of TLR signaling
2003 - 2004 Molecular mechanism of proliferation and differentiation of hepatocyte.
2002 - 2003 Functions of Thymic Epithelial Cells
2001 - 2002 間葉系幹細胞の発生,増殖と分化機構の解析
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Papers (75)：
Tatsuya Kometani, Koki Kamo, Taketomo Kido, Nobuyoshi Hiraoka, Taku Chibazakura, Kenji Unno, Keisuke Sekine. Development of a novel co-culture system using human pancreatic cancer cells and human iPSC-derived stellate cells to mimic the characteristics of pancreatic ductal adenocarcinoma in vitro. Biochemical and biophysical research communications. 2023. 658. 1-9
Ryota Yasui, Atsuka Matsui, Keisuke Sekine, Satoshi Okamoto, Hideki Taniguchi. Highly Sensitive Detection of Human Pluripotent Stem Cells by Loop-Mediated Isothermal Amplification. Stem cell reviews and reports. 2022
Johannes Krumm, Keisuke Sekine, Patroklos Samaras, Agnieska Brazovskaja, Markus Breunig, Ryota Yasui, Alexander Kleger, Hideki Taniguchi, Mathias Wilhelm, Barbara Treutlein, et al. High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development. Cell reports. 2022. 38. 13. 110604-110604
