Rchr
J-GLOBAL ID：200901012949975025
Update date: Apr. 19, 2024
Kawashima Hidekazu
Kawashima Hidekazu | Kawashima Hidekazu
Affiliation and department：
Job title：
Associate Professor
Research field (2)：
Radiology
, Pharmaceuticals - analytical and physicochemistry
Research keywords (7)：
SPECT
, PET
, Translational Research
, Theranostics
, Nuclear Medicine
, Molecular imaging
, Radiopharmaceutical Science
Research theme for competitive and other funds (24)：
- 2023 - 2028 Development of medical Tc drugs using Tc isotopes and development of a medical gamma-ray camera for clinical applications
- 2023 - 2026 骨格筋の新機能としての老廃物除去機能を解明する
- 2021 - 2024 Elucidation of mechanisms underlying lifestyle-related diseases and malignant tumors based on in vivo imaging of scavenger receptors
- 2019 - 2022 Development of exosome-capturing antibody-conjugated nucleic acid medicines against multiple myeloma
- 2017 - 2019 Development and application of novel chemical compounds to materialize the cancer theranostics
- 2015 - 2018 Development of 125I-labeled probe for the detection of macrophage-like cells in inflammatory lesion
- 2014 - 2018 Development of an image reconstruction algorithm for image improvement of ultra-high spatial resolution SPECT for molecular functional quantitation in a selected small region
- 2014 - 2018 Usefulness of imaging tumor-specific enzyme expression by radiopharmaceuticals with thymidine phosphorylase inhibitory potency
- 2013 - 2016 Development of noninvasive PET system with 15O labeled gas tracers in small animals for understanding cerebral ischemic disease
- 2010 - 2012 Development of molecular imaging probes for measurement of mass in pancreatic islets.
- 2010 - 2012 Diagnostic imaging of breast cancer using newly-developed dedicated PET scanners.
- 2010 - 2011 Synthesis and evaluation of an in vivo imaging probe for tumor based on the intracellular transporting system
- 2007 - 2009 Development of probes for the systematic analysis of Alzheimer's disease : establishment of a new diagnostic imaging.
- 2007 - 2008 脳機能再生機構の解析と分子イメージング~臨床画像診断の実現を目指して~
- 2007 - 2008 Development of a brain β-secretase imaging probe for the very early detection of Alzheimer's disease
- 2005 - 2007 DEVELOPMENT OF NOVEL RADIOPHARMACEUTICALS FOR EARLY STAGE DIAGNOSIS OF CEREBRAL NEURODEGENERATION AND FUNCTIONAL RECOVERRY AFTER INTRASTRIATAL GRAFTS
- 2006 - 2006 マイクロリアクタによるポジトロンプローブの合成:チップ型自動合成装置の開発へ
- 2005 - 2006 Quantitative Analysis of Nicotinic Acetylcholine Receptors in Human Brain ; Effects of Aging and Smoking Cessation
- 2005 - 2006 ESTABLISHMENT AND CLINICAL APPLICATION OF PROLIFERATION ACTIVITY AND MALIGNANT GRADE EVALUATION WITH POSITRON EMISSION TOMOGRAPHY.
- 2005 - 2006 酸素応答分解型タンパクを用いる低酸素領域のインビボ放射性イメージング法の開発
- 2005 - 2006 腫瘍の悪性度・転位能の評価を目的とした新規組織トラップ型核医学診断薬剤の開発
- 2003 - 2004 EVALUATION OF THERAPEUTIC EFFECT BY POSITRON EMISSION TOMOGRAPHY USING FLUORINATED THYMIDINE DELIVATIVE
- 2003 - 2004 Monitoring radiation therapy to the head and neck tumor by FLT-PET.
- 2002 - 2003 核酸合成・PG合成酵素のインビボイメージング:腫瘍・炎症の鑑別診断への挑戦
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Papers (100)：
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Marina Omokawa, Hiroyuki Kimura, Yuichi Hatsukawa, Hidekazu Kawashima, Kazuaki Tsukada, Yusuke Yagi, Yuki Naito, Hiroyuki Yasui. Production and synthesis of a novel 191Pt-labeled platinum complex and evaluation of its biodistribution in healthy mice. Bioorganic & Medicinal Chemistry. 2024. 97. 117557-117557
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Marina Omokawa, Hiroyuki Kimura, Kenji Arimitsu, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Yuki Naito, Hiroyuki Yasui. Synthesis and Biological Evaluation of a Novel Sugar-Conjugated Platinum(II) Complex Having a Tumor-Targeting Effect. ACS Omega. 2023
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Yuto Kondo, Hiroyuki Kimura, Minon Sasaki, Sumina Koike, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Hiroyuki Yasui. Effect of Water on Direct Radioiodination of Small Molecules/Peptides Using Copper-Mediated Iododeboronation in Water-Alcohol Solvent. ACS Omega. 2023
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Aina Fukuda, Souichi Nakashima, Yoshimi Oda, Kaneyasu Nishimura, Hidekazu Kawashima, Hiroyuki Kimura, Takashi Ohgita, Eri Kawashita, Keiichi Ishihara, Aoi Hanaki, et al. Plantainoside B in Bacopa monniera binds to Aβ aggregates attenuating neuronal damage and memory deficits induced by Aβ. Biol. Pharm. Bull. 2022. 46. 2. 320-333
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Kento Hosomi, Hidekazu Kawashima, Atsushi Nakano, Akemi Kakino, Yuko Okamatsu-Ogura, Yuki Yamashita, Mai Sasaoka, Daisaku Masuda, Shizuya Yamashita, Chu-Huang Chen, et al. NanoSPECT imaging reveals the uptake of 123I-labelled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36. Cardiovascular Research. 2022. 119. 4. 1008-1020
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MISC (86)：
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福田 愛菜, 中嶋 聡一, 尾田 好美, 西村 周泰, 花木 葵, 河嶋 秀和, 木村 寛之, 中村 誠宏, 松本 崇宏, 岡崎 瑞紀, et al. Bacopa monniera由来Aβ結合性低分子化合物によるAβの検出と神経保護作用の解析. 日本生薬学会年会講演要旨集. 2022. 68回. 133-133
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面川 真里奈, 木村 寛之, 初川 雄一, 河嶋 秀和, 安井 裕之. 新規糖連結白金錯体を用いたがん治療薬の開発. 日本薬学会年会要旨集. 2022. 142年会. 27PO4-10S
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面川 真里奈, 木村 寛之, 初川 雄一, 河嶋 秀和, 安井 裕之. 新規糖連結白金錯体の191Pt標識体の合成と薬剤特性の評価. アイソトープ・放射線研究発表会. 2022. 2. 84
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古川 武典, 木村 寛之, 志賀 智華, 吉村 茜音, 屋木 祐亮, 河嶋 秀和, 安井 裕之. Erythropoietin-producing hepatocellular A2受容体を標的とした腫瘍イメージングプローブの開発. アイソトープ・放射線研究発表会. 2022. 2. 83
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田中未紗, 木村寛之, 宮本佳美, 桶谷亮, 河嶋秀和, 安井裕之. Evaluation of transplanted islets using molecular imaging technology. 日本薬学会年会要旨集(CD-ROM). 2020. 140th
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Books (3)：
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臨床放射薬学 : 薬学領域における放射化学の理論と実践
京都廣川書店 2022 ISBN:9784910844039
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Handbook of in vivo chemistry in mice : from lab to living system
Wiley-VCH 2020 ISBN:9783527344321
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Resistance to Ibritumomab in Lymphoma
2018
Lectures and oral presentations (16)：
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Synthesis of Radioiodinated Peptides by Direct and Indirect Radiolabeling Using a Copper-Mediated Iododeboronation
(The 5th International Symposium on Halogen Bonding 2022)
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Improved Image Quality in X-ray Fluorescence Computed Tomography by Combining Dual-Energy Scatter Correction and High-Sensitivity Multi-Pinhole Collimator
(2022 IEEE Nuclear Science Symposium 2022)
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動脈硬化モデルマウスにおける泡沫化マクロファージを標的とした放射性ヨウ素標識酸化LDLを用いた生体イメージングの解析
(第96回日本薬理学会年会 2022)
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生薬由来Aβ結合性低分子化合物の神経保護作用の解析
(第41回日本認知症学会学術集会 2022)
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酸化LDL標識体を用いた動脈硬化モデルマウスにおける泡沫化マクロファージを標的とした動脈硬化巣バイオイメージングの検討
(2022)
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Education (2)：
- - 2002 Kyoto University Graduate School of Pharmaceutical Sciences
- - 1997 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
Professional career (1)：
- Ph. D. (Pharmaceutical Sciences) (Kyoto University)
Work history (6)：
- 2016/01 - 現在 Kyoto Pharmaceutical University Radioisotope Research Center Associate Professor
- 2014/01 - 2015/12 Health Sciences University of Hokkaido Division of Radiopharmaceutical Chemistry, School of Pharmaceutical Sciences Associate Professor
- 2010/04 - 2013/12 National Cerebral and Cardiovascular Center, Research Institute Laboratory of Diagnostic Molecular Imaging, Department of Investigative Radiology Chief
- 2004/02 - 2010/03 Graduate School of Pharmaceutical Sciences Department of Patho-Functional Bioanalysis Research Scientist
- 2004/02 - 2010/03 Graduate School of Medicine, Kyoto University Department of Nuclear Medicine and Diagnostic Imaging Assistant Professor
- 2002/03 - 2004/01 Institute of Biomedical Research and Innovation Department of Image-based Medicine Research Scientist
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Association Membership(s) (8)：
日本分子イメージング学会
, 日本核医学会
, 日本薬学会
, Society of Radiopharmaceutical Sciences
, World Molecular Imaging Society
, Society of Nuclear Medicine and Molecular Imaging
, 放射性薬品科学研究会
, 日本薬学教育学会
